Results 231 to 240 of about 87,228 (284)

TREM2 in Macrophages Promotes Renal Fibrosis via Activation of β‐Catenin Signalling Pathway in Obstructive Nephropathy

Cell Proliferation, EarlyView.
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) promotes obstructive nephropathy progression by activating the β‐catenin signalling pathway, driving M2 macrophage polarisation, migration and fibrogenic gene expression. targeted inhibition of TREM2 thus represents a promising novel strategy against renal fibrosis.
Jia Wei, Zixia Li, Gengyu Du, Ting Chen, Min Yang, Zhen Yuan, Yidan Zheng, Xiang Yan   +7 more
wiley   +1 more source

Myofibroblast-Derived Extracellular Vesicles Drive Profibrotic Cascade Amplification in Pulmonary Fibrosis via the Nestin-Rab7 Axis. [PDF]

J Extracell Vesicles
Lai X, Xiao Y, Lin Y, Yao S, Wang B, Chen H, Lei T, Huang S, Lei C, Zeng Q, Qiu Y, Chen H, Wang T, Wang J, Xiang AP.   +14 more
europepmc   +1 more source

[Myofibroblastic tumors].

Pathologica, 2000
R, Boldrini, R, Biselli, C, Bosman
openaire   +1 more source

11‐year‐old girl presenting with blurred vision and progressive right arm weakness

Brain Pathology, EarlyView.
Trung Toan Tran, Thi My Hanh Luong, Bérengère Dadone‐Montaudié, Hong Nhung Ta, Thai Hoc Nguyen, Fanny Burel‐Vandenbos, Gia Du Pham   +6 more
wiley   +1 more source

Current Trends in the Epidemiology of Obesity and the Association Between Obesity and Metabolic Liver Disease (MASLD/MASH)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Excess adiposity and obesity are increasingly prevalent, with incidence rising in many parts of the world; both trigger a state of metabo‐inflammation in adipose tissue, creating a systemic milieu characterised by insulin resistance and pro‐inflammatory and fibrogenic states. Along with systemic inflammatory cues, perturbations in systemic and
Mirjana Grocic, Madison Nguyen, Arun J. Sanyal   +2 more
wiley   +1 more source

BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/SMAD3 in TGF-β1 pathway. [PDF]

Biochem Biophys Rep
Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wang Y.   +5 more
europepmc   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Macrophage-to-myofibroblast transition (MMT) - An adverse response to polypropylene mesh implanted for pelvic organ prolapse repair surgery in a non-human primate model. [PDF]

Biomaterials
Therriault MA, Knight K, Kottapalli S, Obisesan T, Harinath M, Brown BN, Moalli PA.   +6 more
europepmc   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Profibrotic predictive toxicology in the lung. [PDF]

Front Pharmacol
Singh P, Sinha R, Antony VB.
europepmc   +1 more source