Results 81 to 90 of about 73,235 (299)

GAS5 decreased the arecoline-induced myofibroblasts activity in buccal mucosal fibroblasts via acting as a competing endogenous RNA for miR-21

Journal of Dental Sciences
Background/purpose: Oral submucous fibrosis (OSF) is recognized as a premalignant condition that increases the risk of oral cancer. Myofibroblasts are the primary cellular mediators of the pathological fibrosis characteristic of OSF.
Chuan-Hang Yu, Heng-Yi Liao, Jung-Chun Yeh, Shih-Min Wang, Ming-Yi Lu, Yi-Wen Liao, Cheng-Chia Yu, Fu-Chen Lin   +7 more
doaj   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Myofibroblast differentiation of porcine cardiac valve interstitial cells [PDF]

, 2008
We examined myofibroblast differentiation in VICs from porcine aortic valves. In normal valves, cells positive for a-SMA were rare, but spatially abundant in sclerotic valves. Hoechst 33342 dye identified 0.5% of VICs that are side population cells, none
Pho, Mindy
core   +1 more source

Biology of Fibroblasts and Myofibroblasts [PDF]

Proceedings of the American Thoracic Society, 2008
Abstract Despite their importance in fibrosis, the origin of fibroblasts and the genesis of the various subpopulations characterized by distinct phenotypes remain unclear. Various studies have described distinct and relatively stable phenotypes in fibroblasts isolated from lung tissue undergoing remodeling, which were not present in ...
openaire   +2 more sources

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Ogerin induced activation of Gpr68 alters tendon healing

FASEB BioAdvances
Satisfactory outcomes after acute tendon injuries are hampered by a fibrotic healing response. As such, modulation of extracellular matrix deposition and remodeling represents an important intervention point to improve healing. During fibrosis, matrix is
Andrew Rodenhouse, Gilbert Smolyak, Emmanuela Adjei‐Sowah, Neeta Adhikari, Samantha Muscat, Takuma Okutani, Constantinos Ketonis, Anne E. C. Nichols, Robert M. Kottmann, Alayna E. Loiselle   +9 more
doaj   +1 more source

Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling

JACC: Basic to Translational Science
Summary: USP9X plays a crucial role in myocardial fibrosis. This study showed increased USP9X expression in myocardial infarction models, associated with collagen deposition and myofibroblast activation.
Xuelian Li, MM, Shijiu Jiang, MD, Wenling Yang, MM, Xianjie Zhu, MM, Fan Zhang, MM, Zhiyang Li, MM, Xiaopeng Guo, MD, PhD, Yumiao Wei, MD, PhD   +7 more
doaj   +1 more source

Corneal stroma PDGF blockade and myofibroblast development

, 2009
Myofibroblast development and haze generation in the corneal stroma is mediated by cytokines, including transforming growth factor-beta (TGF-beta), and possibly other cytokines.
SINGH, Nirbhai, CHAURASIA, Shyam S., WILSON, Steven E., KAUR, Harmeet, MEDEIROS, Fabricio W. de, AMBATI, Balamurali K., AGRAWAL, Vandana, SALOMAO, Marcella Q.   +7 more
core   +1 more source