Results 1 to 10 of about 94,921 (285)
ESSENTIAL ROLE OF LYN IN FIBROSIS [PDF]
Frontiers in Physiology, 2016 Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Hung Pham +10 more
doaj +4 more sources
Inflammatory myofibroblastic tumor
Contemporary Clinical Dentistry, 2011 Inflammatory myofibroblastic tumor is an uncommon lesion of unknown cause. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate.
Sangeeta Palaskar +3 more
doaj +3 more sources
Extracellular PKM2 facilitates organ-tissue fibrosis progression
iScience, 2021 Summary: Persistent activation of fibroblasts and resistance of myofibroblasts to turnover play important roles in organ-tissue fibrosis development and progression.
Hongwei Han +7 more
doaj +1 more source
Current Opinion in Rheumatology, 2013 Interest in the myofibroblast as a key player in propagation of chronic progressive fibrosis continues to elicit many publications, with focus on its cellular origins and the mechanisms underpinning their differentiation and/or transition. The objective of the review is to highlight this recent progress.The epithelial origin of the myofibroblast in ...
Biao, Hu, Sem H, Phan
openaire +2 more sources
Myofibroblasts. II. Intestinal subepithelial myofibroblasts [PDF]
American Journal of Physiology-Cell Physiology, 1999 Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and proliferate in response to various growth factors, particularly the platelet-derived growth factor (PDGF) family, which includes PDGF-BB and stem cell factor ...
D W, Powell +5 more
openaire +2 more sources
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]
, 2015 In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D +11 more
core +19 more sources
Editorial: Liver Myofibroblasts [PDF]
Frontiers in Physiology, 2016 Myofibroblasts (MFB) were first identified in the granulation tissue of healing wounds. They have features of both fibroblasts and smooth muscle cells. In contrast to fibroblasts they contain cytoplasmic actin microfilaments (stress fibers) connected to the extracellular matrix (ECM) by focal contacts.
Kanta, Jiri +2 more
openaire +3 more sources
Scientific Reports, 2021 Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described.
Giuseppina Abignano +5 more
doaj +1 more source
A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. [PDF]
, 2020 Alveolar formation increases the surface area for gas-exchange and is key to the physiological function of the lung. Alveolar epithelial cells, myofibroblasts and endothelial cells undergo coordinated morphogenesis to generate epithelial folds (secondary
Chou, Yu-Ting +7 more
core +1 more source
Comparison of Myofibroblasts Between Solid/Multicystic Ameloblastoma and Unicystic Ameloblastoma: An Immunohistochemical Analysis [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Microenvironment is crucial for the maintenance of cellular functions and tissue integrity suggesting that cancer-induced changes in the stroma may contribute to cancer invasion and its biological behaviour. One of the major constituent
Gowdara Prakash Smitha +3 more
doaj +1 more source