Results 91 to 100 of about 73,741 (198)

Stromal myofibroblasts are drivers of invasive cancer growth.

, 2008
Tissue integrity is maintained by the stroma in physiology. In cancer, however, tissue invasion is driven by the stroma. Myofibroblasts and cancer-associated fibroblasts are important components of the tumor stroma.
Mareel, Marcus, Bracke, Marc E., Demetter, Pieter, De Wever, Olivier, Bracke, Marc   +4 more
core   +1 more source

Drug targeting to myofibroblasts: Implications for fibrosis and cancer [PDF]

, 2017
Myofibroblasts are the key players in extracellular matrix remodeling, a core phenomenon in numerous devastating fibrotic diseases. Not only in organ fibrosis, but also the pivotal role of myofibroblasts in tumor progression, invasion and metastasis has ...
Bansal, Ruchi, Yazdani, Saleh, Saleh Yazdani, Ruchi Bansal, Jai Prakash, Bansal, Ruchi; id_orcid, Prakash, Jai   +6 more
core   +2 more sources

Effect of Keratinocytes on Myofibroblasts in Hypertrophic Scars

, 2019
Myofibroblasts play a central role in matrix formation and wound contraction during wound healing and undergo apoptosis at the end of the healing. Hypertrophic scarring is a pathologic condition in which myofibroblasts persist in the tissue.
Chung, Ho Yun, Jeon, Sewha, Kim, Tae Jung, Lee, Yong Jig, Yang, Jung Dug, Ko, Ung Hyun, Cho, Byung Chae, Shin, Jennifer H., Lee, Joon Seok, Kim, Jong Seong, Lee, Jeong Woo, Choi, Kang Young, Oh, Eun Jung   +12 more
core   +1 more source

Corneal myofibroblasts and fibrosis

Experimental Eye Research, 2020
Myofibroblasts are alpha-smooth muscle actin (SMA)+ cells that have a critical role in the corneal stromal response to infections, injuries, and surgeries, and which produce corneal scarring fibrosis when they develop in excess. These contractile and opaque cells-produce large amounts of disordered extracellular matrix (ECM)-and develop from keratocyte-
openaire   +3 more sources

Generation and analysis of spheroids from human primary skin myofibroblasts: an experimental system to study myofibroblasts deactivation

, 2017
Myofibroblasts are activated fibroblasts involved in tissue repair and cancer. They are characterized by de novo expression of α-smooth muscle actin (α-SMA), immunoregulatory phenotype and paracrine interaction with normal and tumorigenic cells leading ...
GRANATO, GIUSEPPINA, RUOCCO, MARIA ROSARIA, MASONE, STEFANIA, MONTAGNANI, STEFANIA, Maria R Ruocco, AVAGLIANO, ANGELICA, ARCUCCI, ALESSANDRO, DI SPIGNA, GAETANO, RUSSO, VALENTINA, BELLEVICINE, CLAUDIO, Fiume, Giuseppe, Claudio Bellevicine, Stefania Masone, Antonino Iaccarino, Gaetano Di Spigna, Alessandro Arcucci, IACCARINO, ANTONINO, Gaetano Calì, Calì, Gaetano, Valentina Russo, Giuseppe Fiume, Giuseppina Granato, Angelica Avagliano, Stefania Montagnani   +23 more
core   +1 more source

MTA inhibits DNA synthesis in myofibroblasts.

, 2013
MTA Effects on cyclin D1 and JunD expression. Effect of MTA on FCS-induced [3H]thymidine incorporation in myofibroblasts treated as indicated (24 h) (A). Cyclin D1 mRNA expression in myofibroblasts treated (12 h) with 10% FCS and MTA as indicated.
Saioa Goñi (358304), Sara Arcelus (358306), Nerea Juanarena (358307), Fernando J. Corrales (358310), Miriam Méndez (358305), Jesús M. Banales (102475), Jon Lecanda (132740), Carmen Berasain (113819), M. Ujue Latasa (358297), Carlos M. Rodríguez-Ortigosa (102458), Raquel Urtasun (113805), Maite G. Fernández-Barrena (5653318), Juan A. Recio (358308), Matías A. Ávila (5653321), Jesús Prieto (22724), Carmen Gil-Puig (358300), Sophie Lotersztajn (358309)   +16 more
core   +1 more source

Identificação dos colágenos I, III, IV e α-SMA e participação dos miofibroblastos no processo fibrótico das endometroses equinas

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO A endometrose é uma alteração degenerativa das glândulas uterinas e do estroma circundante, caracterizada pelo arranjo periglandular de miofibroblastos e pela deposição de matriz extracelular (ECM).
L.D. Costa, M.C. Dias, M.A. Alvarenga, J.L. Sequeira   +3 more
doaj   +1 more source

The rise and fall of glucocorticoids and immunosuppressants in idiopathic pulmonary fibrosis: a historical paradigm shift driven by mechanistic understanding

Frontiers in Immunology
The therapeutic strategy for Idiopathic Pulmonary Fibrosis (IPF) has undergone a fundamental transformation over recent decades. Combination therapy with glucocorticoids and immunosuppressants, particularly the “triple therapy” regimen including ...
Bing Wen, Bing Wen, Xue Wu, Xue Wu, Xiaosheng Ma, Dan Li, Li Qian   +6 more
doaj   +1 more source

Inflammatory myofibroblastic tumor in pediatric patients: a Bosnian cohort

Medicinski Glasnik
Aim:Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm of intermediate biological potential, characterized by spindle cell proliferation and significant inflammatory component.
Asmir Jonuzi, Ilhana Tinjak, Melika Bukvic, Benjamin Kulovac, Nusret Popovic, Emir Milisic, Zlatan Zvizdic   +6 more
doaj   +1 more source

Tracing cell lineages in health and disease: experimental and human studies [PDF]

, 2010
PhDThis study aimed to investigate stem cell biology in the normal and diseased pancreas and liver employing robust methods for tracking stem cells and their progeny in both pre-clinical and human scenario.
Lin, Wey-Ran
core