Results 101 to 110 of about 43,668 (265)

Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function

open access: yesAging Cell, EarlyView.
Diabetes‐induced upregulation of miR‐103a‐3p suppresses Rnd3 expression in cardiomyocytes, thereby promoting the senescence‐associated secretory phenotype (SASP) through activation of the STAT3 signaling pathway, mediated by UPS‐induced degradation of p‐STAT3.
Linxu Wu   +16 more
wiley   +1 more source

Ex Vivo Preservation of Porcine Vascularized Composite Soft Tissue Allografts

open access: yesArtificial Organs, EarlyView.
The aim of this study was to evaluate the effectiveness of ex vivo perfusion (EVP) for vascularized composite tissue preservation. EVP preserved abdominal free flaps for 24 h within physiologic parameters and without development of edema. EVP may extend preservation time and geographic reach for VCAs.ABSTRACTIntroductionThe aim of this study was to ...
Abigail Meyers   +13 more
wiley   +1 more source

A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease

open access: yesActa Ophthalmologica, EarlyView.
Abstract Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder that significantly impacts patients' quality of life, with prevalence rates ranging from 5% to 50% and higher incidence in women.
Antonio J. Mateo Orobia   +4 more
wiley   +1 more source

Assessment of Fasting Metabolism With Microdialysis Indicates Earlier Lipolysis in Children With VLCADD Than MCADD

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim To investigate fasting metabolism in children with very long‐chain acyl‐CoA dehydrogenase deficiency (VLCADD) and medium‐chain acyl‐CoA dehydrogenase deficiency (MCADD) using microdialysis technique. Methods Twelve patients (7 with VLCADD, 5 with MCADD, mean age 4.9 years, 10/12 diagnosed via newborn screening) were recruited for ...
David Olsson   +4 more
wiley   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms.
Miguel A. Olivencia   +14 more
wiley   +1 more source

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

open access: yesNeuropathology, EarlyView.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata   +6 more
wiley   +1 more source

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