Results 71 to 80 of about 115,678 (349)

Probabilistic classification of acute myocardial infarction from multiple cardiac markers [PDF]

, 2008
Logistic regression and Gaussian mixture model (GMM) classifiers have been trained to estimate the probability of acute myocardial infarction (AMI) in patients based upon the concentrations of a panel of cardiac markers.
C Bishop, F Dombal de, F Fesmire, F Fesmire, George W. Irwin, H Selker, J Ellenuis, J Habbema, J Habbema, J Habbema, J Hanley, J Hilden, J Hilden, John V. Lamont, L Goldman, L Goldman, M Pozen, Paul C. Wilson, Robert F. Harrison, T Groth, W Tierney   +20 more
core   +1 more source

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

Animal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin, Mathieu Magnin, Axel Aigle, Timothée Schuhler, Jean‐Yves Ayoub, Romain Lac, Charlotte Slek, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier   +9 more
wiley   +1 more source

(R)-α-Lipoic acid inhibits fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro

BMC Complementary and Alternative Medicine, 2018
Background Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times.
Hardik Ghelani, Valentina Razmovski-Naumovski, Rajeswara Rao Pragada, Srinivas Nammi   +3 more
doaj   +1 more source

Rise CKMB and Myoglobin Levels in Non-Cardiac Patients of Ischemic Stroke Presenting to Emergency Department of a Tertiary Care Hospital

Pakistan Armed Forces Medical Journal, 2022
Objective: To assess the rise in CKMB and Myoglobin levels and associated factors in non-cardiac patients of ischemic stroke presenting to the Emergency Department of a Tertiary Care Hospital. Study Design: Cross-sectional study.
Muhammad Dawood, Yasir Abbas, Asif Hashmat, Andaleeb Khan, Kamil Rehman Butt, Shahana Rehman   +5 more
doaj   +1 more source

Fractal Analysis of Protein Potential Energy Landscapes

, 1998
The fractal properties of the total potential energy V as a function of time t are studied for a number of systems, including realistic models of proteins (PPT, BPTI and myoglobin).
A. E. García, B. B. Mandelbrot, B. Dubuc, D. A. Hamburger-Lidar, D. A. Lidar, D. Thirumalai, D. Thirumalai, H. Frauenfelder, J. C. Russ, J. E. Straub, K. D. Ball, K. Falconer, M. Doi, P. G. Wolynes, P. Pfeifer, R. B. Gerber, R. Czerminski, R. Elber, R. Elber   +18 more
core   +1 more source

Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser

Nature Communications, 2015
Light absorption can trigger biologically relevant protein conformational changes. The light-induced structural rearrangement at the level of a photoexcited chromophore is known to occur in the femtosecond timescale and is expected to propagate through ...
M. Levantino, G. Schirò, H. Lemke, G. Cottone, J. Glownia, D. Zhu, M. Chollet, H. Ihee, A. Cupane, M. Cammarata   +9 more
semanticscholar   +1 more source

Development of an efficient mice model of cancer‐associated cardiac cachexia

Animal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong, Huiting Zheng, Teng Wu, Jing Tan, Tongsheng Huang, Conghui Shen, Yuanjun Ji, Mengying Liu, Junhong Wan, Weibin Cai   +9 more
wiley   +1 more source

The structure of protein molecules : in celebration of the International Year of Crystallography, 2014 [PDF]

, 2014
Many people, including laymen, are aware of the double helical nature of the DNA molecule. A few may actually realise that it was the technique of X-ray crystallography that was the key to solving this structure.
Bonetta, Rosalin, Farrugia, Diane, Hunter, Gary J., Hunter, Therese, Vella, Marita   +4 more
core   +1 more source

Hemoadsorption therapy for myoglobin removal in rhabdomyolysis: consensus of the hemoadsorption in rhabdomyolysis task force

BMC Nephrology
Background Rhabdomyolysis describes a syndrome characterized by muscle necrosis and the subsequent release of creatine kinase and myoglobin into the circulation.
Lui Forni, Filippo Aucella, Gabriella Bottari, Stefan Büttner, Vincenzo Cantaluppi, Dietmar Fries, Jan Kielstein, Detlef Kindgen-Milles, Claus Krenn, Andreas Kribben, Andreas Meiser, Steffen Mitzner, Marlies Ostermann, Vedran Premuzic, Caroline Rolfes, Christina Scharf, Stefan Schunk, Zsolt Molnar, Alexander Zarbock   +18 more
doaj   +1 more source

Site-Directed Mutagenesis of Myoglobin for Studies of Their Interaction with Iron(III) by Multi-Spectroscopic Techniques

Journal of Spectroscopy, 2013
In order to investigate how the amino acids on the surface of myoglobin molecule influence myoglobin's structure and function, a variety of spectroscopy techniques were applied in the study of the interaction between Fe(III) and myoglobin (wild type and ...
Qian Tang, Xiao-Jun Peng, Hong-Yu Cao, Yan-Jie Yang, Jing Ma, Jing-Yun Wang, Xue-Fang Zheng   +6 more
doaj   +1 more source