Results 71 to 80 of about 1,633 (129)

Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources

The FEBS Journal, EarlyView.
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani, Marco Gargiulo, Elia Lio, Enrico Mario Alessandro Fassi, Giovanni Grazioso, Maria Assunta Chiacchio, Barış Binay, Stefania Brocca, Francesco Secundo   +8 more
wiley   +1 more source

Correlation Between Early Serum Myoglobin Levels and the Incidence and Prognosis of Intensive Care Unit-Acquired Weakness (ICU-AW) in Septic Shock Patients: A Comparative Study

Anais da Academia Brasileira de Ciências
Intensive Care Unit-acquired weakness (ICU-AW) is a common complication that significantly impedes patient recovery. In the study, we investigated the correlation between early serum myoglobin levels in patients with septic shock due to pneumonia, and ...
LING WANG, DENGYAN LONG
doaj   +1 more source

Iron Overload: Pathophysiology, Diagnosis and Monitoring

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Iron overload is associated with significant health risks, underscoring the importance of understanding its pathophysiology as well as establishing accurate diagnostic and monitoring methods. Chronic iron overload is associated with either genetic disorders characterized by excessive iron accumulation (hereditary hemochromatosis), or is ...
Elena Chatzikalil, Polyxeni Delaporta, Konstantinos Bistas, Antonis Kattamis   +3 more
wiley   +1 more source

Protein Structural Modeling Explains Rapid Oxidation in Poultry and Fish Myoglobins Compared to Livestock Myoglobins

Proteomes
Background: This study aimed to investigate rapid oxidation in poultry and fish myoglobin compared to livestock myoglobin using protein structural differences and bioinformatics tools. Methods: Myoglobins from beef (Bos taurus), bison (Bos bison), sheep (
Greeshma Sreejesh, Surendranath P. Suman, Gretchen G. Mafi, Morgan M. Pfeiffer, Ranjith Ramanathan   +4 more
doaj   +1 more source

Physicochemical Quality and Chemical Safety of Commercial Wet Cat Food: Composition, Oxidation, Biogenic Amines, and Trace Elements

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study investigated the physicochemical characteristics and chemical safety of commercial wet cat foods marketed in Brazil. Twenty products labeled as beef, chicken and fish flavors were analyzed for proximate composition, pH, lipid and protein oxidation, biogenic amines, and essential and potentially toxic trace elements.
Marina Teixeira de Vries Mársico, Eliane Teixeira Mársico, Celso Fasura Balthazar, João Paulo de Sá Felizardo, Roberto Meigikos dos Anjos, Erick Almeida Esmerino, Sérgio Borges Mano   +6 more
wiley   +1 more source

Phylogenomics of the American robin (Turdus migratorius) reveals hidden lineages and introgression

Journal of Systematics and Evolution, EarlyView.
Phylogenomic analyses of Turdus migratorius uncover four previously unrecognized lineages, including a divergent Baja California lineage (T. m. confinis). The results reveal complex evolutionary relationships that depart from simple models of continuous divergence, supported by evidence of introgression between the Mexican lineage and its previously ...
Wendoly Rojas‐Abreu, Christen M. Bossu, Luz E. Zamudio‐Beltrán, Borja Milá, Kristen Ruegg, Blanca E. Hernández‐Baños   +5 more
wiley   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Parenteral iron—Does it increase infection risk?

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Iron deficiency (ID) and iron deficiency anaemia (IDA) are prevalent conditions impacting various patient populations, both surgical and non‐surgical conditions. The advent of patient blood management (PBM) has promoted intravenous (IV) iron therapy as an alternative to oral iron and blood transfusions.
Joyisa Deb, Aswin K. Mohan, Suhasini Sil, Suvro Sankha Datta, Yoghini Nagandran, Manideepa Maji, Mohammad Kamrul Hassan Majumder, Saikat Mandal   +7 more
wiley   +1 more source

Kidney replacement and conservative therapies in rhabdomyolysis: a retrospective analysis

BMC Nephrology
Background Toxic renal effects of myoglobin following rhabdomyolysis can cause acute kidney injury (AKI) with the necessity of kidney replacement therapy (KRT).
Jonathan de Fallois, Robert Scharm, Tom H. Lindner, Christina Scharf, Sirak Petros, Lorenz Weidhase   +5 more
doaj   +1 more source