Labor-associated gene expression in the human uterine fundus, lower segment, and cervix [PDF]
, 2006 Background Preterm labor, failure to progress, and postpartum hemorrhage are the common causes of maternal and neonatal mortality or morbidity. All result from defects in the complex mechanisms controlling labor, which coordinate changes in the ...
Aguan +37 more
core +7 more sources
Influence of smooth muscle contractility by inhibition of crac channels activity
European Pharmaceutical Journal, 2017 The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC
Kocmálová M., Kazimierová I.
doaj +1 more source
Differential expression of microRNA-206 and its target genes in pre-eclampsia [PDF]
, 2015 Objectives: Pre-eclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify novel circulating miRNAs in maternal plasma that may be ...
Akehurst, Christine +12 more
core +1 more source
Frontiers in Endocrinology, 2023 IntroductionPreterm birth is one of the major causes of neonatal morbidity and mortality across the world. Both term and preterm labour are preceded by inflammatory activation in uterine tissues.
Lucia Riaposova +14 more
doaj +1 more source
The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]
, 2009 Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Carson, Ray J. +4 more
core +5 more sources
Two Giant Cystic Uterine Adenomyomas in a Premenopausal Woman: The Largest Case to Date With Immunohistochemical Findings. [PDF]
Case Rep Obstet GynecolBackground and Aims Cystic adenomyoma is a rare focal cystic variant of adenomyosis, and giant lesions are particularly uncommon. Malignant transformation has been reported in endometriosis‐related disease, but the molecular features of cystic adenomyoma, especially in adults, remain unclear.
Kitami K +7 more
europepmc +2 more sources
Dye diffusion during laparoscopic tubal patency tests may suggest a lymphatic contribution to dissemination in endometriosis: A prospective, observational study [PDF]
, 2019 Aim Women with adenomyosis are at higher risk of endometriosis recurrence after surgery. This study was to assess if the lymphatic vessel network drained from the uterus to near organs where endometriosis foci lied.
Bonaccorsi, G. +6 more
core +1 more source
Molecular evidence of functional progesterone withdrawal in human myometrium
Nature Communications, 2016 Progesterone suppresses uterine contractility acting through its receptors (PRA/B). The mechanism by which human labour is initiated in the presence of elevated circulating progesterone has remained an enigma since Csapo first theorized of a functional ...
Lubna Nadeem +5 more
semanticscholar +1 more source
OESTROGEN METABOLISM IN SHEEP MYOMETRIUM [PDF]
Reproduction, 1974 Ovine myometrium obtained at 127 and 119 days of gestation was incubated in vitro with [4-14C]oestrone and [6,7-3H2]oestradiol\x=req-\ 17\g=a\, and [4-14C]oestrone and [6,7-3H2]oestrone-3-sulphate, respectively. It was considered significant that oestrone was converted mainly to the much more potent oestradiol-17\g=b\ with very little transformation to
G, Rossier, C G, Pierrepoint
openaire +2 more sources
Transcription Analysis of the Myometrium of Labouring and Non-Labouring Women
PLoS ONE, 2016 An incomplete understanding of the molecular mechanisms that initiate normal human labour at term seriously hampers the development of effective ways to predict, prevent and treat disorders such as preterm labour. Appropriate analysis of large microarray
G. Sharp +5 more
semanticscholar +1 more source