Results 191 to 200 of about 380,707 (403)
Advanced Science, EarlyView.Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley +1 more source
Angewandte Chemie, EarlyView.This study advances top‐down individual ion mass spectrometry (I2MS) to profile intact phospho‐proteoforms of β‐ and α‐catenins (85–110 kDa) within cadherin–catenin complexes. By modulating actomyosin contractility, we reveal mechano‐sensitive phosphorylation patterns and propose that distinct catenin proteoforms may reflect adhesive states at cell ...
Che‐Fan Huang +4 more
wiley +2 more sources
Advanced Intelligent Systems, EarlyView.A six‐element viscoelastic model is presented for tissue‐engineered skeletal muscle, addressing the limitations of the conventional Hill's model. By introducing an active branch, the model accurately describes force responses in both elongation and isometric tests and successfully predicts the electrically induced displacement of a reverse‐action ...
Mizuki Nakamura +6 more
wiley +1 more source
Development of an efficient mice model of cancer‐associated cardiac cachexia
Animal Models and Experimental Medicine, EarlyView.This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong +9 more
wiley +1 more source
Enhanced Skeletal Muscle Contraction with Myosin Light Chain Phosphorylation by a Calmodulin-sensing Kinase [PDF]
, 2007 Jeffrey W. Ryder +3 more
openalex +1 more source
Annals of Neurology, EarlyView.Objective Myotonic dystrophy type 1 (DM1) is a highly variable, multisystemic genetic disorder caused by a CTG repeat expansion in the 3′ untranslated region of DMPK. Toxicity is exerted by repeat‐containing DMPK transcripts that sequester muscleblind‐like (MBNL) proteins and lead to deleterious yet predictable changes in alternative splicing.
Samuel T. Carrell +3 more
wiley +1 more source
The α‐kinases TRPM6 and TRPM7, but not eEF‐2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC [PDF]
, 2008 Kristopher Clark +6 more
openalex +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 A. Mentes +7 more
semanticscholar +1 more source
Incidence and Prevalence of Congenital Myopathies ‐ A Population‐Based Study From Western Sweden
Annals of Neurology, EarlyView.Objective Congenital myopathies are a group of rare genetic muscle disorders. Previous studies have estimated point prevalences which only include surviving individuals. Our aim was to perform an epidemiological study with strict inclusion criteria, using modern diagnostic technology to present both incidences and prevalences, and to describe the ...
Eva Michael +5 more
wiley +1 more source
A curvilinear Model Approach: Actin Cortex Clustering Due to ATP-induced Myosin Pulls
, 2016 Christian Wölfer +2 more
openalex +1 more source