Results 211 to 220 of about 181,791 (317)
Cryo-EM structure of shutdown human nonmuscle myosin 2A. [PDF]
Sci AdvCasas-Mao D, Carrington G, Peckham M.
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British Journal of Pharmacology, EarlyView.Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira +3 more
wiley +1 more source
Identification and intracellular functional characterization of myosin XI and VIII in the lycophyte Selaginella moellendorffii. [PDF]
PlantaTachibana K, Obara J, Tominaga M.
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Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
Non-muscle tropomyosins inhibit myosin-19 and dynamically localize to mitochondrially associated actin filaments. [PDF]
J Biol ChemThompson CP +4 more
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British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
Incidence of Ventricular Arrhythmias and Sudden Cardiac Death with Cardiac Myosin Inhibitors in Hypertrophic Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials. [PDF]
J Pers MedKatic J, Bulum T, Borovac JA.
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Clinical Genetics, EarlyView.The Burden: Hearing loss (HL) is the most prevalent sensory disorder globally, affecting 1.5 million individuals in Brazil. The Gap: While > 150 genes are linked to HL, the genetic architecture in underrepresented populations like Brazil is poorly defined. The Problem: This lack of data limits diagnostic yield and the application of precision medicine.
Stella Diogo‐Cavassana +7 more
wiley +1 more source
Spatial control of myosin regulatory light chain phosphorylation modulates cardiac thick filament mechanosensing. [PDF]
Proc Natl Acad Sci U S ASquarci C +4 more
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Cell Proliferation, EarlyView.The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang +11 more
wiley +1 more source