Results 231 to 240 of about 199,830 (310)

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

open access: yesPhytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng   +6 more
wiley   +1 more source

Preliminary Immunohistochemical Assessment of Slow-Fiber Distribution and Clustering in Skeletal Muscles of 4-Week- and 6-Month-Old Pigs. [PDF]

open access: yesAnimals (Basel)
Furukawa M   +8 more
europepmc   +1 more source

Neohesperidin Alleviates Ferroptosis in Doxorubicin‐Induced Cardiotoxicity via Mettl3‐m6A‐Nrf2 Signaling

open access: yesPhytotherapy Research, EarlyView.
Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen   +9 more
wiley   +1 more source

Complication management in hypertrophic cardiomyopathy. [PDF]

open access: yesHeart Fail Rev
Höller V   +6 more
europepmc   +1 more source

Ganoderic Acids Alleviate Dexamethasone‐Induced Muscle Atrophy Potentially via Regulating Protein Synthesis/Degradation, Attenuating Oxidative Stress, and Antagonizing Glucocorticoid Receptor

open access: yesPhytotherapy Research, EarlyView.
This work proposes a mechanism in which ganoderic acid A (GAA), the active monomer of ganoderic acids (GA) from Ganoderma lucidum, binds to the glucocorticoid receptor (GR) to form a GR‐GAA complex, thereby inhibiting DEX‐induced GR activation. This inhibition suppresses oxidative stress (ROS, MDA and 4‐HNE) by upregulating antioxidant proteins (Nrf2 ...
Kecheng Tang   +10 more
wiley   +1 more source

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance. [PDF]

open access: yesNat Commun
Häkkinen HM   +10 more
europepmc   +1 more source

Electrochemical and Biological Evaluation of Patterned TiO2@TiC‐Nanowires for Bio‐Interface Electrode

open access: yesSmall, EarlyView.
This study introduces a room‐temperature process to fabricate patterned TiO2@TiC core–shell nanowires, merging the biocompatibility of TiO2‐NWs with the high conductivity of TiC. Through sputtering pressure and time modulation, the nanowires morphology and electrochemical properties are tuned, enabling enhanced capacitance, stability, and guided ...
Roaa Sait   +16 more
wiley   +1 more source

Myosin II-independent contraction of actin filaments in membrane nanotubes. [PDF]

open access: yesProc Natl Acad Sci U S A
Ashraf MA   +5 more
europepmc   +1 more source

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