Cardiac Myosin Inhibitors as a Novel Treatment Option for Obstructive Hypertrophic Cardiomyopathy: Addressing the Core of the Matter [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Ahmad Masri, Iacopo Olivotto
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Cardiac myosin inhibitors: a silver lining for an old disease [PDF]
Open HeartSandeep Singh +2 more
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Cardiac myosin inhibitors in hypertrophic cardiomyopathy. [PDF]
J Cardiovasc ImagingAbstract Mavacamten, the first selective and reversible cardiac myosin inhibitor (CMI), has been introduced to the clinical arena for the treatment of obstructive hypertrophic cardiomyopathy (HCM). By reducing excessive actin-myosin cross-bridging, this agent decreases myocardial contractility and alleviates the dynamic left ventricular ...
Lim J, Kim HK.
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Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies
Frontiers in Physiology, 2022 Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and sudden death.
Masataka Kawana +3 more
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Myosin inhibitors for treatment of hypertrophic cardiomyopathy. [PDF]
Cochrane Database Syst RevThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: PRIMARY OBJECTIVE: To assess the effects of myosin inhibitors compared to usual care or placebo on exercise capacity, need for septal reduction therapy, and all‐cause mortality in people with hypertrophic cardiomyopathy (HCM).
Quill S +6 more
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Azidoblebbistatin, a photoreactive myosin inhibitor [PDF]
Proceedings of the National Academy of Sciences, 2012 Photoreactive compounds are important tools in life sciences that allow precisely timed covalent crosslinking of ligands and targets. Using a unique technique we have synthesized azidoblebbistatin, which is a derivative of blebbistatin, the most widely used myosin inhibitor.
M. Kepiro +6 more
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Small-Molecule Inhibitors of Myosin Proteins [PDF]
Future Medicinal Chemistry, 2012 Advances in screening and computational methods have enhanced recent efforts to discover/design small-molecule protein inhibitors. One attractive target for inhibition is the myosin family of motor proteins. Myosins function in a wide variety of cellular processes, from intracellular trafficking to cell motility, and are implicated in several human ...
Bond, L.M. +3 more
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Enhanced tumor cell killing by ultrasound after microtubule depolymerization
Bioengineering & Translational Medicine, 2021 Recent studies show that tumor cells are vulnerable to mechanical stresses and undergo calcium‐dependent apoptosis (mechanoptosis) with mechanical perturbation by low‐frequency ultrasound alone.
Aditi Singh +6 more
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Measurement of junctional tension in epithelial cells at the onset of primitive streak formation in the chick embryo via non-destructive optical manipulation [PDF]
, 2020 Directional cell intercalations of epithelial cells during gastrulation has in several organisms been shown to be associated with a planar cell polarity in the organisation of the actin-myosin cytoskeleton and is postulated to reflect directional tension
Antin +39 more
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Contribution of host intracellular transport machineries to intercellular movement of turnip mosaic virus. [PDF]
PLoS Pathogens, 2013 The contribution of different host cell transport systems in the intercellular movement of turnip mosaic virus (TuMV) was investigated. To discriminate between primary infections and secondary infections associated with the virus intercellular movement ...
Maxime Agbeci +4 more
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