Results 41 to 50 of about 50,593 (147)

Opportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics

Cells, 2023
Cytoskeleton organization and dynamics are rapidly regulated by post-translational modifications of key target proteins. Acting downstream of the Cdc42 GTPase, the myotonic dystrophy-related Cdc42-binding kinases MRCKα, MRCKβ, and MRCKγ have recently ...
Vanessa M. Ruscetta, Taj J. Seaton, Aleen Shakeel, Stanley N. S. Vasconcelos, Russell D. Viirre, Marc J. Adler, Michael F. Olson   +6 more
doaj   +1 more source

Mavacamten facilitates myosin head ON‐to‐OFF transitions and shortens thin filament length in relaxed mouse skeletal muscle

Physiological Reports
The first‐in‐its‐class cardiac drug mavacamten shifts myosin heads towards a structurally inactive position where they lay along the helical tracks of the thick filament.
Michel N. Kuehn, Nichlas M. Engels, Devin L. Nissen, Johanna K. Freundt, Weikang Ma, Samantha P. Harris, Thomas C. Irving, Wolfgang A. Linke, Anthony L. Hessel   +8 more
doaj   +1 more source

Reactive oxygen species are involved in regulating α₁-adrenoceptor-activated vascular smooth muscle contraction

Journal of Biomedical Science, 2010
Background Reactive oxygen species (ROS) were shown to mediate aberrant contractility in hypertension, yet the physiological roles of ROS in vascular smooth muscle contraction have remained elusive.
Tsai Ming-Ho, Jiang Meei
doaj   +1 more source

Myosin IIb activity and phosphorylation status determines dendritic spine and post-synaptic density morphology. [PDF]

PLoS ONE, 2011
Dendritic spines in hippocampal neurons mature from a filopodia-like precursor into a mushroom-shape with an enlarged post-synaptic density (PSD) and serve as the primary post-synaptic location of the excitatory neurotransmission that underlies learning ...
Jennifer L Hodges, Karen Newell-Litwa, Hannelore Asmussen, Miguel Vicente-Manzanares, Alan Rick Horwitz   +4 more
doaj   +1 more source

Mechanisms of Basement Membrane Micro-Perforation during Cancer Cell Invasion into a 3D Collagen Gel

Gels, 2022
Cancer invasion through basement membranes represents the initial step of tumor dissemination and metastasis. However, little is known about how human cancer cells breach basement membranes.
Shayan S. Nazari, Andrew D. Doyle, Kenneth M. Yamada   +2 more
doaj   +1 more source

A myosin inhibitor impairs auxin-induced cell division

Protoplasma, 2003
The role of myosins for auxin-induced cell division was probed using the inhibitor 2,3-butanedione monoxime in the tobacco cell line VBI-0, where cell elongation and division are axially aligned under the control of auxin. A morphometric analysis revealed that cell division is blocked in a dose-dependent manner, whereas cell expansion continued.
Holweg, Carola, Honsel, Anne, Nick, Peter   +2 more
openaire   +4 more sources

Glioma Cell Migration on Three-dimensional Nanofiber Scaffolds Is Regulated by Substrate Topography and Abolished by Inhibition of STAT3 Signaling

Neoplasia: An International Journal for Oncology Research, 2011
A hallmark of malignant gliomas is their ability to disperse through neural tissue, leading to long-term failure of all known therapies. Identifying new antimigratory targets could reduce glioma recurrence and improve therapeutic efficacy, but screens ...
Paula A. Agudelo-Garcia, Jessica K. De Jesus, Shante P. Williams, Michal O. Nowicki, Ennio Antonio Chiocca, Sandya Liyanarachchi, Pui-Kai Li, John J. Lannutti, Jed K. Johnson, Sean E. Lawler, Mariano S. Viapiano   +10 more
doaj   +1 more source

Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis. [PDF]

PLoS ONE, 2013
Sepsis, a major cause of morbidity/mortality in intensive care units worldwide, is commonly associated with cardiac dysfunction, which worsens the prognosis dramatically for patients.
Mara R N Celes, Lygia M Malvestio, Sylvia O Suadicani, Cibele M Prado, Maria J Figueiredo, Erica C Campos, Ana C S Freitas, David C Spray, Herbert B Tanowitz, João S da Silva, Marcos A Rossi   +10 more
doaj   +1 more source

Protein Kinase C Inhibitors as Modulators of Vascular Function and Their Application in Vascular Disease

Pharmaceuticals, 2013
Blood pressure (BP) is regulated by multiple neuronal, hormonal, renal and vascular control mechanisms. Changes in signaling mechanisms in the endothelium, vascular smooth muscle (VSM) and extracellular matrix cause alterations in vascular tone and blood
Raouf A. Khalil
doaj   +1 more source

Sulphate is a competitive inhibitor of the binding of nucleotide to myosin A comparison with phosphate [PDF]

FEBS Letters, 1988
By the use of rapid reaction methods (rapid flow quench and stopped flow) it has been shown that sulphate is a competitive inhibitor of the binding of ε‐ATP and ATP to myosin. At low ionic strengths, the K i was in the micromolar range. Under several conditions used sulphate was more effective than phosphate.
TESI, CHIARA, BARMAN T, TRAVERS F.
openaire   +3 more sources