Results 41 to 50 of about 750,133 (244)

Treatment of obstructive hypertrophic cardiomyopathy: the role of modern imaging and the place of surgery in the era of myosin inhibitors

Zaporožskij Medicinskij Žurnal
Aim. To evaluate modern approaches to preoperative planning of septal myectomy in patients with obstructive hypertrophic cardiomyopathy (HCM), to define the role of multimodality imaging (echocardiography, magnetic resonance imaging (MRI), computed ...
M. O. Tregubova, K. V. Rudenko, M. M. Tkachenko, P. A. Danchenko, A. O. Bei   +4 more
doaj   +1 more source

Spheroid Fabrication Using Concave Microwells Enhances the Differentiation Efficacy and Function of Insulin-Producing Cells via Cytoskeletal Changes

Cells, 2020
Pancreatic islet transplantation is the fundamental treatment for insulin-dependent diabetes; however, donor shortage is a major hurdle in its use as a standard treatment. Accordingly, differentiated insulin-producing cells (DIPCs) are being developed as
Yu Na Lee, Hye Jin Yi, Hanse Goh, Ji Yoon Park, Sarah Ferber, In Kyong Shim, Song Cheol Kim   +6 more
doaj   +1 more source

Discovery of Selective Inhibitors for In Vitro and In Vivo Interrogation of Skeletal Myosin II

, 2021
Myosin IIs, actin-based motors that utilize the chemical energy of adenosine 5′-triphosphate (ATP) to generate force, have potential as therapeutic targets.
James R. Sellers, Patrick R. Griffin (554018), Li Lin (111038), Mackenzie Geedy (11477832), Courtney A. Miller, Paolo Pasetto (3035298), James R. Sellers (409112), Laszlo Radnai (11477814), Xiaomin Jin (2095897), Gavin Rumbaugh, Gavin Rumbaugh (6195584), Rebecca F. Stremel (11477826), Patrick R. Griffin, Theodore M. Kamenecka, Michael Conlon (11477841), Aagam Patel (11477838), Xiaomin Jin, Erica J. Young (11477823), Madalyn Hafenbreidel, Madalyn Hafenbreidel (11477820), Matthew Surman, Theodore M. Kamenecka (131143), Li Lin, Aagam Patel, Rebecca F. Stremel, Joni-Rae Partridge (11477835), Laszlo Radnai, Michael Conlon, Matthew Surman (11477817), Mackenzie Geedy, Joni-Rae Partridge, Bilel Bdiri (11477829), Bilel Bdiri, Michael D. Cameron (1315059), Courtney A. Miller (5429459), Paolo Pasetto, Michael D. Cameron, Erica J. Young   +37 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Allosteric myosin motor domain binding sites.

, 2020
Allosteric modulators of myosin motor domains overlaid onto the structure of FgMyoI. Switch 2 is shown in pink. Myosin inhibitors: Pentachloropseudilin (PDB 2XEL [18]), pentabromopseudilin (PDB 2JHR [24]), blebbistatin (PDB 1YV3 [37 ...
Karsten Melcher (301766), X. Edward Zhou (8566920), Joseph S. Brunzelle (2394862), Yuxin Zhou (496784), H. Eric Xu (177044), Yuanye Zhu (2621176), Xiaoman Cao (8566926), Feng Zhang (6548), Mingguo Zhou (2621173), Yuanping Gong (8566923)   +9 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Small-molecule inhibitors of myosin proteins

, 2013
Advances in screening and computational methods have enhanced recent efforts to discover/design small-molecule protein inhibitors. One attractive target for inhibition is the myosin family of motor proteins. Myosins function in a wide variety of cellular
Kendrick-Jones, J., Buss, F., Tumbarello, D.A., Bond, L.M.   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The development of novel myosin inhibitors [PDF]

, 2011
This thesis describes a structure activity relationship (SAR) study on the recently discovered small molecule tool blebbistatin (S)-21 with particular emphasis on the development of novel synthetic protocols suitable for the rapid synthesis of libraries ...
Lawson, Christopher Peter Abiodun Tevi
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source