Results 21 to 30 of about 50,593 (147)
Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma
iScience, 2020 Summary: Invasion and proliferation are defining phenotypes of cancer, and in glioblastoma blocking one stimulates the other, implying that effective therapy must inhibit both, ideally through a single target that is also dispensable for normal tissue ...
Rajappa S. Kenchappa +20 more
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Contribution of host intracellular transport machineries to intercellular movement of turnip mosaic virus. [PDF]
PLoS Pathogens, 2013 The contribution of different host cell transport systems in the intercellular movement of turnip mosaic virus (TuMV) was investigated. To discriminate between primary infections and secondary infections associated with the virus intercellular movement ...
Maxime Agbeci +4 more
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Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines. [PDF]
PLoS ONE, 2014 The neuronal actin-binding protein drebrin A forms a stable structure with F-actin in dendritic spines. NMDA receptor activation causes an exodus of F-actin bound by drebrin A (DA-actin) from dendritic spines, suggesting a pivotal role for DA-actin ...
Toshiyuki Mizui +7 more
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The Globular Tail Domain of Myosin Va Functions as an Inhibitor of the Myosin Va Motor [PDF]
Journal of Biological Chemistry, 2006 The actin-activated ATPase activity of full-length mammalian myosin Va is well regulated by Ca2+, whereas that of truncated myosin Va without the C-terminal globular tail domain (GTD) is not. Here, we have found that exogenous GTD is capable of inhibiting the actin-activated ATPase activity of GTD-deleted myosin Va.
Li, Xiang-Dong +4 more
openaire +3 more sources
HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70
Cell Reports, 2019 Summary: HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name “histone” deacetylase, HDAC4
Liqing Luo +13 more
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Intrinsic migratory properties of cultured Schwann cells based on single-cell migration assay. [PDF]
PLoS ONE, 2012 The migration of Schwann cells is critical for development of peripheral nervous system and is essential for regeneration and remyelination after nerve injury.
Ying Wang, Hong-Lin Teng, Zhi-hui Huang
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Scientific Reports, 2023 Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease.
Ashley N. Sharpe +11 more
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Efficacy and Safety of Selective Cardiac Myosin Inhibitors in the Treatment of Hypertrophic Cardiomyopathy: a Meta-analysis [PDF]
Zhongguo quanke yixueBackground Hypertrophic cardiomyopathy (HCM) is a genetic disorder, characterized primarily by left ventricular outflow tract obstruction and asymmetric myocardial hypertrophy, which predisposes to sudden cardiac death and malignant arrhythmias. Although
ZHANG Huijuan, LI Xinghui, ZHANG Xiaoming, YIN Long, SHAO Long
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Therapeutic Advances in Chronic Disease, 2022 Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterised by unexplained left ventricular hypertrophy. Left ventricular outflow tract obstruction is an integral component of the disease, often resulting in significant symptoms, but ...
Susan Mathai, Lynne Williams
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Scientific Reports, 2017 Migration of olfactory ensheathing cells (OECs) is critical for development of olfactory system and essential for neural regeneration after OEC transplantation into nerve injury site.
Cheng-gen Zheng +9 more
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