Results 31 to 40 of about 750,133 (244)

Efficacy and Safety of Selective Cardiac Myosin Inhibitors in the Treatment of Hypertrophic Cardiomyopathy: a Meta-analysis [PDF]

Zhongguo quanke yixue
Background Hypertrophic cardiomyopathy (HCM) is a genetic disorder, characterized primarily by left ventricular outflow tract obstruction and asymmetric myocardial hypertrophy, which predisposes to sudden cardiac death and malignant arrhythmias. Although
ZHANG Huijuan, LI Xinghui, ZHANG Xiaoming, YIN Long, SHAO Long
doaj   +1 more source

Left ventricular outflow tract obstruction in hypertrophic cardiomyopathy and the impact of mavacamten

Therapeutic Advances in Chronic Disease, 2022
Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterised by unexplained left ventricular hypertrophy. Left ventricular outflow tract obstruction is an integral component of the disease, often resulting in significant symptoms, but ...
Susan Mathai, Lynne Williams
doaj   +1 more source

A kinetic model describing the processivity of Myosin-V [PDF]

, 2005
The precise details of how myosin-V coordinates the biochemical reactions and mechanical motions of its two head elements to engineer effective processive molecular motion along actin filaments remain unresolved.
Turner, Matthew S., Turner, MS, Skau, Karl I., Skau, KI, Hoyle, Rebecca B., Hoyle, RB   +5 more
core   +1 more source

Myosin II reactivation and cytoskeletal remodeling as a hallmark and a vulnerability in melanoma therapy resistance [PDF]

, 2020
© 2019 The Authors Despite substantial clinical benefit of targeted and immune checkpoint blockade-based therapies in melanoma, resistance inevitably develops.
O Maiques (8349270), SN Karagiannis (8349306), P Karagiannis (8349288), L Boehme (8349297), R Lee (8349291), A Perdrix-Rosell (8349267), M Georgouli (8349282), V Bridgeman (8349285), J Monger (8349276), I Malanchi (8349309), JL Orgaz (8349258), V Sanz-Moreno (8349312), C Tape (8349303), P Pandya (8349294), I Rodriguez-Hernandez (8349273), S Mele (8349279), E Crosas-Molist (8349261), F Wallberg (8349300), A Sadok (8349264)   +18 more
core   +3 more sources

Polarized Distribution of Active Myosin II Regulates Directional Migration of Cultured Olfactory Ensheathing Cells

Scientific Reports, 2017
Migration of olfactory ensheathing cells (OECs) is critical for development of olfactory system and essential for neural regeneration after OEC transplantation into nerve injury site.
Cheng-gen Zheng, Fan Zhang, Xiao-mei Bao, Shi-yang Wu, Peng Wang, Jia-nan Zhou, Yuan Gao, Hong-lin Teng, Ying Wang, Zhi-hui Huang   +9 more
doaj   +1 more source

A New Era in the Management of Hypertrophic Cardiomyopathy

Reviews in Cardiovascular Medicine
Hypertrophic cardiomyopathy (HCM) is a prevalent cardiac disease characterized by marked phenotypic variability. Recent advances in diagnosis and treatment have allowed a personalized approach to the treatment of this disease.
Ana Perez-Asensio, Helena Llamas-Gomez, Ana Lara-Palomo, Alberto Villar-Ruiz, Cesar Jimenez-Mendez, Julian Palomino-Doza   +5 more
doaj   +1 more source

Rho-Associated Kinases and Non-muscle Myosin IIs Inhibit the Differentiation of Human iPSCs to Pancreatic Endoderm

Stem Cell Reports, 2017
Summary: There has been increasing success with the generation of pancreatic cells from human induced pluripotent stem cells (hiPSCs); however, the molecular mechanisms of the differentiation remain elusive.
Taro Toyoda, Azuma Kimura, Hiromi Tanaka, Tomonaga Ameku, Atsushi Mima, Yurie Hirose, Masahiro Nakamura, Akira Watanabe, Kenji Osafune   +8 more
doaj   +1 more source

MYH3‐associated distal arthrogryposis zebrafish model is normalized with para‐aminoblebbistatin

EMBO Molecular Medicine, 2020
Distal arthrogryposis (DA) is group of syndromes characterized by congenital joint contractures. Treatment development is hindered by the lack of vertebrate models.
Julia Whittle, Lilian Antunes, Mya Harris, Zachary Upshaw, Diane S Sepich, Aaron N Johnson, Mayssa Mokalled, Lilianna Solnica‐Krezel, Matthew B Dobbs, Christina A Gurnett   +9 more
doaj   +1 more source

Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells [PDF]

, 2009
© The Authors, 2009 . This article is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. The definitive version was published in Journal of Cell Biology 186 (2009): 727-738, doi:10.1083/jcb ...
Vale, Ronald D., Spudich, James A., Griffis, Eric R., Ronald D. Vale, James A. Spudich, Eric R. Griffis   +5 more
core   +1 more source

Novel Antimalarial Inhibitors That Specifically Target the Invasion Motor Protein Myosin A in Malaria Parasites

Proceedings, 2019
Malaria remains a devastating disease with nearly half a million deaths per year. The WHO reports a stagnating number of new infections every year without a significant decline, as a result of insufficient access to antimalarials in endemic regions as ...
Janna Ehlert, Arne Alder, Viola Introini, Julia Weder, Pietro Cicuta, Tim W. Gilberger, Matthias Preller   +6 more
doaj   +1 more source