Results 51 to 60 of about 50,593 (147)
MPF governs the assembly and contraction of actomyosin rings by activating RhoA and MAPK during chemical-induced cytokinesis of goat oocytes. [PDF]
PLoS ONE, 2010 The interplay between maturation-promoting factor (MPF), mitogen-activated protein kinase (MAPK) and Rho GTPase during actin-myosin interactions has yet to be determined.
Yan-Guang Wu +7 more
doaj +1 more source
The new life of myectomy in the era of myosin inhibitors
Progress in Cardiovascular DiseasesThe management of symptomatic obstructive hypertrophic cardiomyopathy remains a therapeutic clinical challenge. Surgical septal myectomy has long been established as the gold-standard intervention for patients with persistent symptoms despite optimal medical therapy, offering durable symptom relief with low perioperative risk in experienced centers ...
Quarta, Giovanni +10 more
openaire +2 more sources
Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases
Frontiers in Pharmacology, 2017 Myosin light chain kinase (MLCK) induces contraction of the perijunctional apical actomyosin ring in response to phosphorylation of the myosin light chain.
Yongjian Xiong +7 more
doaj +1 more source
An inhibitor of myosin II, blebbistatin, suppresses development of arterial thrombosis
Biomedicine & Pharmacotherapy, 2020 Arterial thrombosis (AT) causes various ischemia-related diseases, which impose a serious medical burden worldwide. As an inhibitor of myosin II, blebbistatin has an important role in thrombosis development. We investigated the effect of blebbistatin on carotid artery ligation (CAL)-induced carotid AT and its potential underlying mechanism.
Yuanyuan, Zhang +7 more
openaire +2 more sources
Frontiers in Molecular BiosciencesChronic heart failure (HF) is a common and frequently occurring disease worldwide, and its traditional treatment methods are undergoing earth-shaking changes.
Xiang Li, Suwen Bai, Yumei Luo
doaj +1 more source
Frontiers in ImmunologyIntroductionThe serine/threonine kinase 17B (STK17B) is involved in setting the threshold for T cell activation and its absence sensitizes T cells to suboptimal stimuli.
Felix Scheuplein +25 more
doaj +1 more source
Perinatal death in pig models of hypertrophic cardiomyopathy carrying sarcomere pathogenic variants
Journal of Molecular and Cellular Cardiology PlusHypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease caused by genetic variants in sarcomeric proteins, particularly in myosin binding protein C3 (MYBPC3) and myosin heavy chain 7 (MYH7).
Tatiana Flisikowska +11 more
doaj +1 more source
Novel cardiac myosin inhibitor for hypertrophic cardiomyopathy
Journal of General PhysiologyNew RLC-1 small-molecule inhibits actomyosin interactions, reduces contractile force, and speeds up myosin cross-bridge kinetics.
openaire +2 more sources
Effects of a Fluorescent Myosin Light Chain Phosphatase Inhibitor on Prostate Cancer Cells
Frontiers in Oncology, 2011 Myosin light chain phosphatase is an enzyme important to regulation of cell cycle and motility that is shown to be upregulated in aggressive prostate cancer cells and tissue.
Scott eGrindrod +5 more
doaj +1 more source
Precision Negative Inotropy: The Rise of Cardiac Myosin Inhibitors in HCM
Journal of Education, Health and SportBackground: Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopathy, marked by left-ventricular hypertrophy, dynamic outflow obstruction in many patients, diastolic dysfunction, and elevated risks of atrial fibrillation and heart ...
Katarzyna Skibicka +3 more
doaj +1 more source