Results 51 to 60 of about 750,133 (244)

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons [PDF]

, 2006
The mechanism by which synaptic vesicles (SVs) are recruited to the release site is poorly understood. One candidate mechanism for trafficking of SVs is the myosin-actin motor system.
Tokuoka, H, Goda, Y
core  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Magnetic resonance imaging evaluation of the effects of myosin inhibitors (mavacamten and aficamten) in hypertrophic cardiomyopathy: a systematic review and case report

Monaldi Archives for Chest Disease
Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disorder, affecting approximately 1 in 250 individuals. It is defined by unexplained left ventricular (LV) hypertrophy in the absence of other identifiable cardiac or systemic causes.
Carolina Bernardes, João Gomes Carvalho, Patrícia Rodrigues, Manuela França   +3 more
doaj   +1 more source

A novel 2.5D culture platform to investigate the role of stiffness gradients on adhesion-independent cell migration. [PDF]

PLoS ONE, 2014
Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness.
Mark-Phillip Pebworth, Sabrina A Cismas, Prashanth Asuri   +2 more
doaj   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells [PDF]

, 2014
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear.
Laura Borgonovo-Brandter (573527), Neus Visa (245920), Gothenburg University., Al-Muzzaini, Bader, Anne Von Euler, Von Euler Anne, Sarshad, Aishe A., Visa, Neus,, Laura Borgonovo-Brandter, Martin Corcoran (573526), Borgonovo-Brandter Laura, Martin Corcoran, Piergiorgio Percipalle (393101), Borgonovo-Brandter, Laura, Visa, Neus, Göteborgs universitet., Lamont, Douglas, Sarshad, Aishe A.,, Corcoran, Martin, Percipalle Piergiorgio, Von Euler, Anne, Percipalle, Piergiorgio, Al-Muzzaini Bader, Corcoran Martin, Visa Neus, Douglas Lamont (573529), Lamont Douglas, Aishe A Sarshad, Bader Al-Muzzaini, Anne Von Euler (573528), Sarshad Aishe A., Von Euler, Anne,, Bader Al-Muzzaini (393098), Douglas Lamont, Aishe A. Sarshad (573525), Neus Visa, Piergiorgio Percipalle, Von, Euler A, Borgonovo-Brandter, L, Percipalle, P,, Visa, N, Corcoran, M,, Lamont, D, Sarshad, AA, Al-Muzzaini, B   +44 more
core   +1 more source

Reduced Graphene Oxide Enhances the Vascular Organization and Contractile Performance of Fibrin‐Gelatin‐Based Engineered Cardiac Tissue

Advanced Materials Interfaces, EarlyView.
Fibrin–gelatin hydrogels functionalized with reduced graphene oxide create a mechanically stable and bioactive 3D environment for engineered cardiac tissue. The composite matrix promotes endothelial lumen formation, enhances sarcomeric protein expression, and increases contractile performance of embedded cardiomyocytes.
Christoph Kuckelkorn, Marie Baiker, Yajuan Jiang, Ebru Aksoy, Kurt Pfannkuche, Horst Fischer   +5 more
wiley   +1 more source

Discovery of Selective Inhibitors for In Vitro and In Vivo Interrogation of Skeletal Myosin II

, 2021
Myosin IIs, actin-based motors that utilize the chemical energy of adenosine 5′-triphosphate (ATP) to generate force, have potential as therapeutic targets.
Madalyn Hafenbreidel (11477820), Patrick R. Griffin (554018), Li Lin (111038), Mackenzie Geedy (11477832), Paolo Pasetto (3035298), James R. Sellers (409112), Theodore M. Kamenecka (131143), Laszlo Radnai (11477814), Xiaomin Jin (2095897), Joni-Rae Partridge (11477835), Gavin Rumbaugh (6195584), Matthew Surman (11477817), Rebecca F. Stremel (11477826), Bilel Bdiri (11477829), Michael D. Cameron (1315059), Michael Conlon (11477841), Courtney A. Miller (5429459), Aagam Patel (11477838), Erica J. Young (11477823)   +18 more
core   +1 more source