A therapeutic leap: how myosin inhibitors moved from cardiac interventions to skeletal muscle myopathy solutions [PDF]
The Journal of Clinical InvestigationThe myosin inhibitor mavacamten has transformed the management of obstructive hypertrophic cardiomyopathy (HCM) by targeting myosin ATPase activity to mitigate cardiac hypercontractility.
Julius Bogomolovas, Ju Chen
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Cardiac Myosin Inhibitors (CMIs) and Surgical Referral in Patients with Hypertrophic Cardiomyopathy [PDF]
Journal of Cardiovascular Development and DiseaseThe management of obstructive hypertrophic cardiomyopathy (HCM) has been transformed by the advent of cardiac myosin inhibitors (CMIs), such as mavacamten and aficamten.
Benedetto Ferraresi +9 more
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Cardiac Myosin Inhibitors in Hypertrophic Cardiomyopathy: Clinical Advances and Therapeutic Prospects [PDF]
Drug Design, Development and TherapyHou L, Lin B, Ji X, Huang A.
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Cardiac Myosin Inhibitors in Hypertrophic Cardiomyopathy: From Sarcomere to Clinic [PDF]
International Journal of Molecular SciencesTakahiro Okumura +2 more
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Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies
Frontiers in Physiology, 2022 Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and sudden death.
Masataka Kawana +3 more
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Azidoblebbistatin, a photoreactive myosin inhibitor [PDF]
Proceedings of the National Academy of Sciences, 2012 Photoreactive compounds are important tools in life sciences that allow precisely timed covalent crosslinking of ligands and targets. Using a unique technique we have synthesized azidoblebbistatin, which is a derivative of blebbistatin, the most widely used myosin inhibitor.
M. Kepiro +6 more
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Small-Molecule Inhibitors of Myosin Proteins [PDF]
Future Medicinal Chemistry, 2012 Advances in screening and computational methods have enhanced recent efforts to discover/design small-molecule protein inhibitors. One attractive target for inhibition is the myosin family of motor proteins. Myosins function in a wide variety of cellular processes, from intracellular trafficking to cell motility, and are implicated in several human ...
Bond, L.M. +3 more
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Specificity of blebbistatin, an inhibitor of myosin II [PDF]
Journal of Muscle Research and Cell Motility, 2004 Blebbistatin is a small molecule inhibitor discovered in a screen for inhibitors of nonmuscle myosin IIA. We have examined the specificity and potency of the drug by assaying its effects on the actin-activated MgATPase assay of diverse members of the myosin superfamily.
Limouze, John +3 more
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The Formin Inhibitor, SMIFH2, Inhibits Members of the Myosin Superfamily [PDF]
Biophysical Journal, 2020 Abstract The small molecular inhibitor of formin FH2 domains, SMIFH2, is widely used in cell biological studies. It was selected in a chemical screen as a compound inhibiting formin-driven actin polymerization in vitro , but not polymerization of pure actin, and found to be active ...
Yukako Nishimura +7 more
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Enhanced tumor cell killing by ultrasound after microtubule depolymerization
Bioengineering & Translational Medicine, 2021 Recent studies show that tumor cells are vulnerable to mechanical stresses and undergo calcium‐dependent apoptosis (mechanoptosis) with mechanical perturbation by low‐frequency ultrasound alone.
Aditi Singh +6 more
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