Results 11 to 20 of about 750,133 (244)

Myosin inhibitors for treatment of hypertrophic cardiomyopathy. [PDF]

Cochrane Database Syst Rev
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:/ / Primary objective: To assess the effects of myosin inhibitors compared to usual care or placebo on exercise capacity, need for septal reduction ...
Quill S, Amin AS, Asselbergs FW, Bezzina C, Elliott PM, van der Velden J, Schmidt AF.   +6 more
europepmc   +3 more sources

Cardiac myosin inhibitors: a silver lining for an old disease [PDF]

Open Heart
Sandeep Singh, Sourabh Agstam, Satyavir Yadav   +2 more
doaj   +2 more sources

Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies

Frontiers in Physiology, 2022
Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and sudden death.
Masataka Kawana, Masataka Kawana, James A. Spudich, Kathleen M. Ruppel   +3 more
doaj   +1 more source

Cardiac Myosin Inhibitors in Hypertrophic Cardiomyopathy: From Sarcomere to Clinic. [PDF]

Int J Mol Sci
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease characterized by unexplained left ventricular hypertrophy, often resulting from pathogenic variants of sarcomeric protein genes.
Nakamura K, Okumura T, Kato S, Onoue K, Kubo T, Kouzu H, Yano T, Inomata T.   +7 more
europepmc   +2 more sources

Cardiac Myosin Inhibitors in Hypertrophic Cardiomyopathy: Clinical Advances and Therapeutic Prospects [PDF]

Drug Design, Development and Therapy
Hou L, Lin B, Ji X, Huang A.
exaly   +2 more sources

Myosin light chain kinase inhibitors and methods of use [PDF]

, 2023
Disclosed are inhibitors of myosin light chain kinase, pharmaceutical compositions and kits comprising the inhibitors and methods of ...

core   +2 more sources

Enhanced tumor cell killing by ultrasound after microtubule depolymerization

Bioengineering & Translational Medicine, 2021
Recent studies show that tumor cells are vulnerable to mechanical stresses and undergo calcium‐dependent apoptosis (mechanoptosis) with mechanical perturbation by low‐frequency ultrasound alone.
Aditi Singh, Ajay Tijore, Felix Margadant, Chloe Simpson, Deepak Chitkara, Boon Chuan Low, Michael Sheetz   +6 more
doaj   +1 more source

Identification of functional differences between recombinant human ? and ? cardiac myosin motors [PDF]

, 2012
The myosin isoform composition of the heart is dynamic in health and disease and has been shown to affect contractile velocity and force generation.
Rezavandi, Heresh, Rezavandi, H., Leslie A. Leinwand, Geeves, M., Leinwand, Leslie A., Leinwand, L., Geeves, Michael A., Marieke J. Bloemink, Heresh Rezavandi, Deacon, John C., Bloemink, Marieke J., Deacon, J., John C. Deacon, Bloemink, M., Michael A. Geeves   +14 more
core   +1 more source

Myosin VI Lever Arm Rotation: Fixed or Variable? [PDF]

, 2010
Two recent articles addressed the power-stroke of myosin VI molecules during stepping. Although both groups measured the angles of fluorescent probes attached on the myosin VI molecule lever arm using polarized fluorescence techniques, they differ about ...
Yujie Sun, Harry W. Schroeder III, Kazuaki Homma, John Beausang, Mitsuo Ikebe, Yale Goldman, John F. Beausang, Harry Schroeder III, Yale E. Goldman   +8 more
core   +1 more source

Alternative Exon 9-Encoded Relay Domains Affect More than One Communication Pathway in the Drosophila Myosin Head [PDF]

, 2009
We investigated the biochemical and biophysical properties of one of the four alternative regions within the Drosophila myosin catalytic domain: the relay domain encoded by exon 9.
Girish C. Melkani, Bernstein, Sanford I., Corey M. Dambacher, Geeves, M., Melkani, Girish C., Knowles, Aileen F., Geeves, Michael A., Marieke J. Bloemink, Aileen F. Knowles, Melanki, G., Bloemink, Marieke J., Bloemink, M., Bernstein, S., Sanford I. Bernstein, Dambacher, C., Knowles, A., Dambacher, Corey M., Michael A. Geeves   +17 more
core   +1 more source