Results 21 to 30 of about 94,421 (295)

Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]

, 2017
In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc, De Wever, Olivier, Roman, Bart, Stevens, Christian, Van Deun, Rik, Van Hecke, Kristof, Verhasselt, Sigrid   +6 more
core   +1 more source

Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines. [PDF]

PLoS ONE, 2014
The neuronal actin-binding protein drebrin A forms a stable structure with F-actin in dendritic spines. NMDA receptor activation causes an exodus of F-actin bound by drebrin A (DA-actin) from dendritic spines, suggesting a pivotal role for DA-actin ...
Toshiyuki Mizui, Yuko Sekino, Hiroyuki Yamazaki, Yuta Ishizuka, Hideto Takahashi, Nobuhiko Kojima, Masami Kojima, Tomoaki Shirao   +7 more
doaj   +1 more source

Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma

iScience, 2020
Summary: Invasion and proliferation are defining phenotypes of cancer, and in glioblastoma blocking one stimulates the other, implying that effective therapy must inhibit both, ideally through a single target that is also dispensable for normal tissue ...
Rajappa S. Kenchappa, Panagiotis Mistriotis, Emily Wisniewski, Santanu Bhattacharya, Tanmay Kulkarni, Rita West, Amanda Luu, Meghan Conlon, Ernest Heimsath, James F. Crish, Hannah S. Picariello, Athanassios Dovas, Natanael Zarco, Montserrat Lara-Velazquez, Alfredo Quiñones-Hinojosa, John A. Hammer, Debrabrata Mukhopadhyay, Richard E. Cheney, Konstantinos Konstantopoulos, Peter Canoll, Steven S. Rosenfeld   +20 more
doaj   +1 more source

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells [PDF]

, 2011
Copyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund. This is an open access article distributed under the terms of the Creative Commons Attribution License ...
Arican, HD, Bridger, JM, Eskiw, CH, Kill, IR, Mehta, IS   +4 more
core   +2 more sources

Intrinsic migratory properties of cultured Schwann cells based on single-cell migration assay. [PDF]

PLoS ONE, 2012
The migration of Schwann cells is critical for development of peripheral nervous system and is essential for regeneration and remyelination after nerve injury.
Ying Wang, Hong-Lin Teng, Zhi-hui Huang
doaj   +1 more source

HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70

Cell Reports, 2019
Summary: HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name “histone” deacetylase, HDAC4
Liqing Luo, Sherry C. Martin, Jascha Parkington, Samuel M. Cadena, Jiang Zhu, Chikwendu Ibebunjo, Serge Summermatter, Nicole Londraville, Krystyna Patora-Komisarska, Leo Widler, Huili Zhai, Anne-Ulrike Trendelenburg, David J. Glass, Jun Shi   +13 more
doaj   +1 more source

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source

Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

Scientific Reports, 2023
Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease in humans and cats and lacks efficacious pharmacologic interventions in the preclinical phase of disease.
Ashley N. Sharpe, Maureen S. Oldach, Victor N. Rivas, Joanna L. Kaplan, Ashley L. Walker, Samantha L. Kovacs, Darren T. Hwee, Peadar Cremin, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern   +11 more
doaj   +1 more source

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes [PDF]

, 2013
The role of the mRNA-binding protein human antigen R (HuR) in stabilization and translation of AU-rich elements (ARE) containing mRNAs is well established.
Doller, Anke, Eberhardt, Wolfgang, Pfeilschifter, Josef Martin, Schulz, Sebastian   +3 more
core   +1 more source

Specificity of blebbistatin, an inhibitor of myosin II [PDF]

Journal of Muscle Research and Cell Motility, 2004
Blebbistatin is a small molecule inhibitor discovered in a screen for inhibitors of nonmuscle myosin IIA. We have examined the specificity and potency of the drug by assaying its effects on the actin-activated MgATPase assay of diverse members of the myosin superfamily.
John, Limouze, Aaron F, Straight, Timothy, Mitchison, James R, Sellers   +3 more
openaire   +2 more sources