Results 51 to 60 of about 8,048 (176)
Aggregate, Volume 7, Issue 1, January 2026.We developed a general tissue‐extraction strategy that directly purifies native F‐actin and actin–tropomyosin–myosin (ATM) complexes from human and rodent muscles for cryo‐EM. Near‐atomic structures, including an HCM R404Q mouse model, reveal how a disease myosin mutation remodels ATM assembly and alters myosin conformation at the actin interface ...
Danni Li +15 more
wiley +1 more source
Rodent models of heart failure: an updated review [PDF]
, 2013 Heart failure (HF) is one of the major health and economic burdens worldwide, and its prevalence is continuously increasing. The study of HF requires reliable animal models to study the chronic changes and pharmacologic interventions in myocardial ...
Bras Silva, C +4 more
core +1 more source
Polymyositis And Dermatomyositis - Inflammation, Muscle Structure & Immunosuppressive Treatment [PDF]
, 2012 Polymyositis and dermatomyositis are chronic, inflammatory disorders characterized by muscle weakness, low muscle endurance and by inflammation in skeletal muscle tissues.
Loell, Ingela
core +1 more source
The FEBS Journal, Volume 293, Issue 2, Page 418-442, January 2026.We analysed collagen XV expression in myocardial infarct samples and assessed how its deficiency affects cardiac responses, such as fibrogenesis and tissue stiffness. In mice, damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel ...
Sanna‐Maria Karppinen +15 more
wiley +1 more source
Journal of Anatomy, Volume 248, Issue 1, Page 126-139, January 2026.Myofibre size and shape were investigated in functionally distinct muscles of humans and mice using ATPase histochemistry and immunofluorescence. In both species, soleus myofibres were found to be larger, more irregularly shaped, and more heterogeneous compared to other muscles. These findings may have implications for biomedical research and potential
Casper Soendenbroe +5 more
wiley +1 more source
Expanding genotype/phenotype of neuromuscular diseases by comprehensive target capture/NGS [PDF]
, 2015 published_or_final_versio
Chen, WT +12 more
core +1 more source
The Journal of Physiology, Volume 604, Issue 2, Page 849-867, 15 January 2026.Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a relatively high volume of voluntary wheel running (VWR) in D2.mdx animals augmented select muscle mass and normalized ex vivo muscle force compared to ...
Stephanie R. Mattina +7 more
wiley +1 more source
A novel MYH7 mutation resulting in Laing distal myopathy in a Chinese family
Chinese Medical Journal, 2019 Written informed consent was obtained from each To the Editor: Distal myopathy is a heterogenetic disorder characterized by early distal lower limb involvement, participant.
Xiangyi Liu +5 more
semanticscholar +1 more source
Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms [PDF]
, 2017 We have studied a cohort of nemaline myopathy (NM) patients with mutations in the muscle α-skeletal actin gene (ACTA1). Immunoblot analysis of patient muscle demonstrates increased γ-filamin, myotilin, desmin and α-actinin in many NM patients, consistent
Clement, Sophie +8 more
core
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.ABSTRACT Background Skeletal muscle plays a vital role in voluntary movement and locomotion. Fast‐twitch muscle fibres are characterized by their rapid contraction kinetics, high‐force generation and a distinct gene expression profile compared to slow‐twitch fibres.
Akhil Baby +4 more
wiley +1 more source