Results 1 to 10 of about 2,484 (223)

Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. [PDF]

open access: yesPLoS ONE, 2008
Myosin folding and assembly in striated muscle is mediated by the general chaperones Hsc70 and Hsp90 and a myosin specific co-chaperone, UNC45. Two UNC45 genes are found in vertebrates, including a striated muscle specific form, Unc45b.
Rajani Srikakulam   +2 more
doaj   +5 more sources

Abnormal myosin post‐translational modifications and ATP turnover time associated with human congenital myopathy‐related RYR1 mutations

open access: yesActa Physiologica, Volume 239, Issue 2, October 2023., 2023
Abstract Aim Conditions related to mutations in the gene encoding the skeletal muscle ryanodine receptor 1 (RYR1) are genetic muscle disorders and include congenital myopathies with permanent weakness, as well as episodic phenotypes such as rhabdomyolysis/myalgia.
Alexander Sonne   +10 more
wiley   +1 more source

New paradigms in actomyosin energy transduction: Critical evaluation of non‐traditional models for orthophosphate release

open access: yesBioEssays, Volume 45, Issue 9, September 2023., 2023
The relative timing of orthophosphate release and the main force‐generating power‐stroke is critical in actomyosin based energy transduction but it remains enigmatic. We here discuss recent models that have introduced various new features to reconcile conflicting findings.
Alf Månsson   +6 more
wiley   +1 more source

Kenneth C. Holmes (1934–2021)

open access: yesJournal of Synchrotron Radiation, Volume 29, Issue 2, Page 591-592, March 2022., 2022
Obituary for Kenneth C.
John Wray, Ilme Schlichting
wiley   +1 more source

Crystallization of myosin subfragment 1. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1984
Crystals of myosin subfragment 1 from avian skeletal muscle have been grown reproducibly. They diffract x-rays to at least 4.5-A resolution. The subfragment 1 crystallizes in space group P2(1)2(1)2(1) where a = 107 A, b = 117 A, and c = 278 A. The cell dimensions and intensity distribution on x-ray diffraction photographs are consistent with two ...
I, Rayment, D A, Winkelmann
openaire   +2 more sources

Mn2+‐Phos‐Tag Polyacrylamide for the Quantification of Protein Phosphorylation Levels

open access: yesCurrent Protocols, Volume 1, Issue 8, August 2021., 2021
Abstract This paper provides a guideline for optimizing and utilizing Mn2+ Phos‐tag gel technology to separate phosphorylated proteins from their unphosphorylated counterparts. It provides key insights into methods for careful sample preparation and experimental directions for determining the appropriate Phos‐tag gel compositions and electrophoresis ...
Kasturi Markandran   +4 more
wiley   +1 more source

Influence of hydrophobic and hydrophilic filler particles on thermal expansion and cooking loss in meat protein gels

open access: yesInternational Journal of Food Science &Technology, Volume 56, Issue 8, Page 3979-3990, August 2021., 2021
Functional properties of filled meat gels are influenced by particle type and concentration. Summary This study aimed to determine the effect of replacing hydrophobic fat‐based particles with hydrophilic inert glass particles at concentrations 10%, 25% and 40% on expansion, contraction and cooking loss of meat protein gels during heat treatment up to ...
Felix‐Alexander Katz   +4 more
wiley   +1 more source

Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega‐7,9 trans‐fat rumenic acid

open access: yesThe Journal of Physiology, Volume 599, Issue 15, Page 3639-3661, 1 August 2021., 2021
Key points Direct binding of rumenic acid to the cardiac myosin‐2 motor domain increases the release rate for orthophosphate and increases the Ca2+ responsiveness of cardiac muscle at low load. Physiological cellular concentrations of rumenic acid affect the ATP turnover rates of the super‐relaxed and disordered relaxed states of β‐cardiac myosin ...
Irene Pertici   +5 more
wiley   +1 more source

High‐pressure processing of meat: Molecular impacts and industrial applications

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 20, Issue 1, Page 332-368, January 2021., 2021
Abstract High‐pressure processing (HPP) has been the most adopted nonthermal processing technology in the food industry with a current ever‐growing implementation, and meat products represent about a quarter of the HPP foods. The intensive research conducted in the last decades has described the molecular impacts of HPP on microorganisms and endogenous
Tomas Bolumar   +9 more
wiley   +1 more source

Nucleotide specificity of the enzymatic and motile activities of dynein, kinesin, and heavy meromyosin. [PDF]

open access: yes, 1991
The substrate specificities of dynein, kinesin, and myosin substrate turnover activity and cytoskeletal filament-driven translocation were examined using 15 ATP analogues.
Furusawa, K   +6 more
core   +2 more sources

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