Results 41 to 50 of about 2,706 (221)
Five models for myosin V [PDF]
Frontiers in Bioscience 14, 2269-2284 (2009), 2008 Myosin V was the first discovered processive motor from the myosin family. It has therefore been subject of a number of mechanical, kinetic, optical and structural studies and now belongs to the best characterised motor proteins. This effort has been accompanied by a number of different theoretical models.
arxiv +1 more source
Human Tonic and Phasic Smooth Muscle Myosin Isoforms Are Unresponsive to the Loop 1 Insert
International Scholarly Research Notices, Volume 2013, Issue 1, 2013., 2013 Smooth muscle myosin gene products include two isoforms, SMA and SMB, differing by a 7‐residue peptide in loop 1 (i7) at the myosin active site where ATP is hydrolyzed. Using chicken isoforms, previous work indicated that the i7 deletion in SMA prolongs strong actin binding by inhibiting active site ingress and egress of nucleotide when compared to i7 ...
Katalin Ajtai +6 more
wiley +1 more source
On the Complexity of Realizability for Safety LTL and Related Subfragments [PDF]
arXiv, 2021 We study the realizability problem for Safety LTL, the syntactic fragment of Linear Temporal Logic capturing safe formulas. We show that the problem is EXP-complete, disproving the existing conjecture of 2EXP-completeness. We achieve this by comparing the complexity of Safety LTL with seemingly weaker subfragments.
arxiv
Spontaneous sarcomere dynamics [PDF]
Chaos 20, 0451222, (2010), 2012 Sarcomeres are the basic force generating units of striated muscles and consist of an interdigitating arrangement of actin and myosin filaments. While muscle contraction is usually triggered by neural signals, which eventually set myosin motors into motion, isolated sarcomeres can oscillate spontaneously between a contracted and a relaxed state.
arxiv +1 more source
Inhibition of skeletal muscle S1-myosin ATPase by peroxynitrite [PDF]
, 2006 Exposure of myosin subfragment 1 (S1) to 3-morpholinosydnonimine (SIN-1) produced a time-dependent inhibition of the F-actin-stimulated S1 Mg2+-ATPase activity, reaching 50% inhibition with 46.7 ( 8.3 íM SIN-1 for 8.7 íM S1, that is, at a SIN-1/S1 molar
Aureliano, M. +4 more
core +1 more source
Small, Volume 20, Issue 51, December 19, 2024.Inherent sensitivity toward external load forms a basis for the myosin motors physiological adaptation. Here, this study shows that the mechanical performance of cardiac and slow skeletal myosin II is determined by the lifetime of force‐producing actin bound myosin states. Load modulates the bound duration, and the steady‐state abundance of actin‐bound
Tianbang Wang +3 more
wiley +1 more source
BioMed Research International, Volume 2012, Issue 1, 2012., 2012 Microfabricated thermoelectric controllers can be employed to investigate mechanisms underlying myosin‐driven sliding of Ca2+‐regulated actin and disease‐associated mutations in myofilament proteins. Specifically, we examined actin filament sliding—with or without human cardiac troponin (Tn) and α‐tropomyosin (Tm)—propelled by rabbit skeletal heavy ...
Nicolas M. Brunet +7 more
wiley +1 more source
ATP-induced reconfiguration of the micro-viscoelasticity of cardiac and skeletal myosin solutions [PDF]
arXiv, 2022 We study the high-frequency micro-mechanical response of suspensions composed by cardiac and skeletal muscle myosin by optical trapping interferometry. We observe that in low ionic strength solutions upon the addition of magnesium adenosine triphosphate (\ch{MgATP^2-}), myosin suspensions radically change their micro-mechanics properties, generating a ...
arxiv
Competitive titration in living sea urchin embryos of regulatory factors required for expression of the CyIIIa actin gene [PDF]
, 1990 Previous studies have located some twenty distinct sites within the 2.3 kb 5' regulatory domain of the sea urchin CyIIIa cytoskeletal actin gene, where there occur in vitro high-specificity interactions with nuclear DNA-binding proteins of the embryo ...
Anderson, Roger +5 more
core
A micro-volume adaptation of a stopped-flow system; use with μg quantities of muscle proteins [PDF]
, 2019 Stopped-flow spectroscopy is a powerful method for measuring very fast biological and chemical reactions. The technique however is often limited by the volumes of reactants needed to load the system.
Behrens, Vincent +4 more
core +1 more source