Mechanochemical consequences of myopathy‐linked mutations in Tpm2.2 on striated muscle contractility
The FASEB Journal, Volume 38, Issue 1, 15 January 2024.Myopathy‐linked mutations in Tpm2.2, an isoform of striated muscle tropomyosin, can lead to hypercontractile or hypocontractile molecular phenotypes. Depending on the localization of the mutations in Tpm2.2 sequence, they have different impacts on the association of Tpm2.2 with actin and the regulation of the actin–myosin cross‐bridge cycle.
Recep Küçükdogru +6 more
wiley +1 more source
Myosin Binding Protein‐C: A Regulator of Actomyosin Interaction in Striated Muscle
BioMed Research International, Volume 2011, Issue 1, 2011., 2011 Myosin‐Binding protein‐C (MyBP‐C) is a family of accessory proteins of striated muscles that contributes to the assembly and stabilization of thick filaments, and regulates the formation of actomyosin cross‐bridges, via direct interactions with both thick myosin and thin actin filaments.
Maegen A. Ackermann +2 more
wiley +1 more source
Cooperation of myosin II in muscle contraction through nonlinear elasticity [PDF]
arXiv, 2023 Myosin II plays a pivotal role in muscle contraction by generating force through the cooperative action of multiple motors on actin filaments. In this study, we integrate the nonlinear elasticity of the neck linker in individual myosin II and comprehensively investigate the evolution of cooperativity and dynamics at {\it microstate} and {\it mesostate}
arxiv
Isolation of Nebulin from Rabbit Skeletal Muscle and Its Interaction with Actin
BioMed Research International, Volume 2010, Issue 1, 2010., 2010 Nebulin is about 800 kDa filamentous protein that binds the entire thin filament of vertebrate skeletal muscle sarcomeres. Nebulin cannot be isolated from muscle except in a completely denatured form by direct solubilization of myofibrils with SDS because nebulin is hardly soluble under salt conditions.
Ryo Chitose +8 more
wiley +1 more source
Induction of Myocarditis and Valvuluitis in Lewis Rats by Different Epitopes of Cardiac Myosin and its Implications in Rheumatic Carditis [PDF]
, 2002 Immune responses against cardiac myosin and group A streptococcal M protein have been implicated in the pathogenesis of rheumatic heart disease.
Cunningham, Madeleine W. +5 more
core
Cardiac Troponin Mutations and Restrictive Cardiomyopathy
BioMed Research International, Volume 2010, Issue 1, 2010., 2010 Mutations in sarcomeric proteins have recently been established as heritable causes of Restrictive Cardiomyopathy (RCM). RCM is clinically characterized as a defect in cardiac diastolic function, such as, impaired ventricular relaxation, reduced diastolic volume and increased end‐diastolic pressure.
Michelle S. Parvatiyar +4 more
wiley +1 more source
The 66 k-Da protein identified as a light meromyosin is involved in the setting of surimi [PDF]
, 1997 The 66 kilo-Dalton (k-Da) protein split off from the cross linked myosin heavy chain (CMHC) formed due to the setting of Alaska pollack surimi, frozen-storage of Pacific cod flesh, and vinegar-curing of Pacific mackerel mince was identified as a light ...
Niwa, E., Nowsad Alam, A.K.M.
core
Conformational and thermal characterization of left ventricle remodeling post-myocardial infarction [PDF]
, 2017 Adverse cardiac remodeling after myocardial infarction (MI) causes impaired ventricular function and heart failure. Histopathological characterization is commonly used to detect the location, size and shape of MI sites.
Bayes-Genis, A +9 more
core +2 more sources
Twirling motion of actin filaments in gliding assays with non-processive myosin motors [PDF]
Biophys. J. 97, 1130-1137 (2009), 2009 We present a model study of gliding assays in which actin filaments are moved by non-processive myosin motors. We show that even if the power stroke of the motor protein has no lateral component, the filaments will rotate around their axis while moving over the surface.
arxiv +1 more source
Making Muscle Elastic: The Structural Basis of Myomesin Stretching [PDF]
, 2012 The muscle M-band protein myomesin comprises a 36-nm long filament made of repetitive immunoglobulin–helix modules that can stretch to 2.5-fold this length, demonstrating substantial molecular ...
A Fukuzawa +42 more
core +4 more sources