Results 161 to 170 of about 8,068 (200)
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1981
The histochemical and ultrastructural study of muscle biopsies of two patients with a chronic muscle weakness and wasting showed particular changes in muscle fibers: (1) peripheral lined vacuoles, containing whorls of membranes and cytoplasmic debris; (2) collections of intranuclear and intrasarcoplasmic tubular filaments (16-18 nm in external diameter
F M, Tomé +3 more
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The histochemical and ultrastructural study of muscle biopsies of two patients with a chronic muscle weakness and wasting showed particular changes in muscle fibers: (1) peripheral lined vacuoles, containing whorls of membranes and cytoplasmic debris; (2) collections of intranuclear and intrasarcoplasmic tubular filaments (16-18 nm in external diameter
F M, Tomé +3 more
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Inclusion body myositis and paramyxoviruses
Human Pathology, 1991Inclusion body myositis (IBM) is a distinct type of muscle disease. The characteristic electron microscopic findings, intranuclear or intracytoplasmic inclusions composed of microtubular filaments, morphologically resemble paramyxovirus nucleocapsids.
M, Kallajoki +5 more
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Inclusion body myositis and myopathies
Annals of Neurology, 1995Preface Part I. Overview of Pathologic and Pathogenic Comparison Between Sporadic Inclusion-Body Myositis and Hereditary Inclusion-Body Myopathies: 1. Newest approaches to diagnosis and pathogenesis of sporadic inclusion-body myositis and hereditary inclusion-body myopathies, including molecular-pathologic similarities to Alzheimer disease Part II ...
R C, Griggs +6 more
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2007
Publisher Summary This chapter discusses inclusion body myositis (IBM). It is usually a slowly progressive myopathy that causes considerable morbidity but does not directly cause mortality. The lack of any effective treatments makes it a challenge to manage.
Michael R, Rose, Robert C, Griggs
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Publisher Summary This chapter discusses inclusion body myositis (IBM). It is usually a slowly progressive myopathy that causes considerable morbidity but does not directly cause mortality. The lack of any effective treatments makes it a challenge to manage.
Michael R, Rose, Robert C, Griggs
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Inclusion body myositis in twins
Neurology, 1998Sporadic inclusion body myositis (s-IBM) is characterized by late onset of slowly progressive weakness that involves the quadriceps and volar forearm muscles early in the course of the disease. There are hereditary forms of inclusion body myopathy (h-IBM) that histologically resemble s-IBM.
A A, Amato, R T, Shebert
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Pathogenesis of inclusion body myositis
Current Opinion in Rheumatology, 2020Purpose of review To review the pathogenesis of inclusion body myositis (IBM). Recent findings IBM is an autoimmune disease. Multiple arms of the immune system are activated, but a direct attack on muscle fibers by highly differentiated T cells drives muscle destruction.
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Spectrum of Inclusion Body Myositis
Archives of Neurology, 1987The clinical, laboratory, and biopsy features are described for a large group of patients with inclusion body myositis (IBM) (15 men and four women; mean age, 63 years). A quantitative histopathologic analysis of muscle biopsy specimens revealed less fiber necrosis and endomysial and perivascular inflammation in IBM than in polymyositis (PM) and ...
S P, Ringel +4 more
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Genetics of inclusion‐body myositis
Muscle & Nerve, 2007AbstractSporadic inclusion‐body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet‐unknown way to cause progressive muscle degeneration and weakness.
Needham, M. +2 more
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Inclusion body myositis and myopathies
Current Opinion in Neurology, 1997Sporadic inclusion body myositis is a frequent, acquired, adult-onset vacuolar myopathy affecting proximal and distal muscles with a distinct, easily identifiable clinical pattern. Although its primary cause is still unknown, autoimmune, viral, and degenerative processes, alone or in combination, are being considered.
K, Sivakumar, M C, Dalakas
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Inclusion body myositis: an update
Current Opinion in RheumatologyPurpose of review To review recent advances in our understanding of the epidemiology, pathophysiology, and management of inclusion body myositis (IBM). Recent findings Recent epidemiologic studies have highlighted the morbidity and mortality associated with IBM, including the impact
Nicolaas C, Anderson, Thomas E, Lloyd
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