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Update on Inclusion Body Myositis
Current Rheumatology Reports, 2018While sporadic inclusion body myositis (sIBM) is the most common acquired muscle disease after age 50, the pathogenesis of this disease is still poorly understood. In this review, we discuss our current state of knowledge in sIBM and provide an update on our current understanding of its pathophysiology and management.Lines of evidence in support of an ...
Duaa, Jabari +3 more
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Biomarkers of inclusion body myositis
Current Opinion in Rheumatology, 2013Inclusion body myositis (IBM) is a poorly understood autoimmune and degenerative disorder of skeletal muscle. Here, pathophysiological and diagnostic biomarkers of IBM are reviewed.Muscle histopathological biomarkers have been successful in stimulating the study of IBM pathophysiology for over three decades.
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Neurology, 1997
Because electrophysiologic, clinical, and histopathologic observations have suggested that inclusion body myositis (IBM) may have a coexistent neurogenic component, we used macro-electromyography (macro-EMG) to search for changes in the motor unit territory and signs of reinnervation. We studied 11 patients, aged 53 to 77 years (mean, 65.2 years), with
C A, Luciano, M C, Dalakas
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Because electrophysiologic, clinical, and histopathologic observations have suggested that inclusion body myositis (IBM) may have a coexistent neurogenic component, we used macro-electromyography (macro-EMG) to search for changes in the motor unit territory and signs of reinnervation. We studied 11 patients, aged 53 to 77 years (mean, 65.2 years), with
C A, Luciano, M C, Dalakas
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Treatment of inclusion body myositis
Current Opinion in Rheumatology, 1999Sporadic inclusion body myositis (s-IBM) is considered the most common muscle disease in patients older than 50 years, with a male predominance. Features of s-IBM include insidious onset, slowly and relentlessly progressive muscle weakness, a characteristic distribution and atrophy of both the proximal and distal muscle groups, and resistance to ...
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Neurology, 2006
Sporadic inclusion-body myositis (s-IBM) describes patients with chronic myositis whose biopsy specimens have, in addition to lymphocytic inflammation, abnormal muscle fibers containing characteristic filamentous inclusions in the cytoplasm and nuclei.
Valerie Askanas +2 more
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Sporadic inclusion-body myositis (s-IBM) describes patients with chronic myositis whose biopsy specimens have, in addition to lymphocytic inflammation, abnormal muscle fibers containing characteristic filamentous inclusions in the cytoplasm and nuclei.
Valerie Askanas +2 more
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Inclusion Body Myositis—A Review
Advances in Anatomic Pathology, 1998Inclusion body myositis (IBM), a sporadic inflammatory myopathy, is the most frequently occurring progressive myopathy in adults older than 55 years. It more commonly affects men and usually is clinically and pathologically distinguishable from dermatomyositis or polymyositis.
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Leukocytapheresis in inclusion body myositis
Journal of Clinical Apheresis, 1987AbstractA patient with inclusion body myositis was treated with a course of 22 leukocytaphereses combined with prednisone and azathioprine therapy. He improved clinically during an induction phase of frequent cytapheresis, which reduced the circulating levels of T lymphocytes and monocytes and decreased the ratio of the T4+ to T8+ lymphocyte subsets ...
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Achalasia and Inclusion Body Myositis
American Journal of Gastroenterology, 2023Amrit K. Kamboj +4 more
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2009
Inclusion body myositis is an insidious, slowly progressive myopathy of middle-aged and older individuals. Because of these characteristics, diagnosis is often delayed. Affected muscle is marked by the presence of rimmed vacuoles, inclusions, and an inflammatory infiltrate largely made up of CD8 T lymphocytes and macrophages.
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Inclusion body myositis is an insidious, slowly progressive myopathy of middle-aged and older individuals. Because of these characteristics, diagnosis is often delayed. Affected muscle is marked by the presence of rimmed vacuoles, inclusions, and an inflammatory infiltrate largely made up of CD8 T lymphocytes and macrophages.
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Global patterns in excess body weight and the associated cancer burden
Ca-A Cancer Journal for Clinicians, 2019Ahmedin Jemal, Susan Gapstur
exaly