Results 61 to 70 of about 8,068 (200)

Perianesthetic Complications in Genetic Mitochondrial Disease: A Review of Case Reports

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Genetic mitochondrial diseases (GMDs) are a large group of genetically and clinically heterogeneous disorders caused by defects in genes encoding mitochondrial components. GMDs are grouped into named syndromes based on clinical presentation, for example, Leigh syndrome (LS).
Brittany M. Johnson, Simon C. Johnson
wiley   +1 more source

Risk Factors for Cutaneous Immune‐Related Adverse Events in the Japanese Population: A Retrospective Single‐Center Cohort Study

The Journal of Dermatology, EarlyView.
ABSTRACT Immune checkpoint inhibitor (ICI)‐driven alterations in the immune system can induce immune‐related adverse events (irAEs). Cutaneous irAEs are notable for being the most common and for their early onset; however, the risk factors underlying their development and severity remain unclear. In this study, we retrospectively analyzed 1224 Japanese
Tomoya Watanabe, Kohei Yamakawa, Miyu Kobayashi, Yusuke Saigusa, Yukie Yamaguchi   +4 more
wiley   +1 more source

The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review

Frontiers in Immunology
Idiopathic inflammatory myopathies (IIMs) are muscle disorders characterized by proximal weakness of the skeletal muscles, inflammation in muscle, and autoimmunity.
Julie J. Paik, Lisa Christopher-Stine, Mikael Boesen, Mikael Boesen, John A. Carrino, S. Peter Eggleton, Deborah Denis, Olga Kubassova   +7 more
doaj   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Targeting peroxynitrite production in a model of persistent temporomandibular disorder comorbid with migraine

British Journal of Pharmacology, EarlyView.
Background and Purpose The persistence of temporomandibular disorders (TMDs), particularly myogenous, in a person with migraine can lead to exacerbated clinical outcomes and limited response to treatment. The pro‐nociceptive reactive nitroxidative species, peroxynitrite, is involved in migraine mechanisms, but little is known of its role in this ...
Simon Akerman, Ana Belen Salinas‐Abarca, Wei Guo, Daniela Salvemini, Marcela Romero‐Reyes   +4 more
wiley   +1 more source

Incidence, severity and potential pathomechanism of immune‐related pruritus in melanoma patients undergoing immune checkpoint inhibitor therapy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Pruritus is a frequent cutaneous immune‐related adverse event (irAE) associated with immune checkpoint inhibitors (ICI), impacting patients' quality of life. This study investigates the incidence, severity and management of pruritus in melanoma patients treated with ICI.
Andrea Roggo, Nikolina Ivanovic, Patrick Turko, Lukas Kraehenbuehl, Mitchell Levesque, Reinhard Dummer, Barbara Meier‐Schiesser   +6 more
wiley   +1 more source

Mitochondrial defects in sporadic inclusion body myositis—causes and consequences

Frontiers in Cell and Developmental Biology
Sporadic inclusion body myositis (sIBM) is a distinct subcategory of Idiopathic Inflammatory Myopathies (IIM), characterized by unique pathological features such as muscle inflammation, rimmed vacuoles, and protein aggregation within the myofibers ...
Elsie Chit Yu Iu, Ho So, Chi Bun Chan
doaj   +1 more source

Miopatías inflamatorias

Revista Médica Clínica Las Condes, 2018
RESUMEN: Las miopatías inflamatorias son un grupo heterogéneo de enfermedades adquiridas del músculo estriado esquelético que comparten la injuria muscular inmunomediada como característica común.
Jorge A. Bevilacqua, MD, PhD, Nicholas Earle, MD   +1 more
doaj   +1 more source

A guide to laser microdissection‐based proteomics

The FEBS Journal, EarlyView.
This review takes researchers through the full laser microdissection proteomics workflow—from tissue preparation and image analysis to sample processing and mass spectrometry—offering practical solutions to common challenges at each step. Real‐world examples from across the field illustrate how the technology is being applied to disease tissue, making ...
Cheng Shen, Kael Schoffer, Charlotte Williams, Maria C. Tanzer   +3 more
wiley   +1 more source

Diagnostic utility of inflammatory markers in formalin‐fixed and paraffin‐embedded muscle biopsies for idiopathic inflammatory myopathies

Histopathology, EarlyView.
Formalin‐fixed, paraffin‐embedded (FFPE) muscle tissue supports robust immunohistochemical detection of MHC II, MxA, and p62 with performance comparable to frozen sections. This approach reliably identifies the pathological signatures of inclusion body myositis, dermatomyositis, immune‐mediated necrotizing myopathy, and overlap myositis, enhancing the ...
Chinnawut Suriyonplengsaeng, Jariya Waisayarat   +1 more
wiley   +1 more source