High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2 [PDF]
, 2018 Myotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by abnormally expanded stretches of CTG DNA triplets in the DMPK gene, leading to mutated-transcript RNA-toxicity.
Cappella, Marisa +11 more
core +2 more sources
Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy
Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 343-357, March 2026.Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman +4 more
wiley +1 more source
The effect of caloric restriction on the forelimb skeletal muscle fibers of 1 the hypertrophic myostatin null mice [PDF]
, 2017 Skeletal muscle mass loss has a broad impact on body performance and physical activity. Muscle wasting occurs due to genetic mutation as in muscular dystrophy, age-related muscle loss (sarcopenia) as well as in chronic wasting disorders as in cancer ...
Arnhold, Stefan +4 more
core +2 more sources
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression
Animal, 2014 MicroRNAs are endogenous ~22nt RNAs that negatively regulate gene expression at the posttranscriptional level via binding to the 3′-untranslated region (3′UTR) of target mRNAs.
T. Yang +11 more
doaj +1 more source
Muscle and serum myostatin expression in type 1 diabetes
Physiological Reports, 2020 Type 1 diabetes (T1D) has been reported to negatively affect the health of skeletal muscle, though the underlying mechanisms are unknown. Myostatin, a myokine whose increased expression is associated with muscle‐wasting diseases, has not been reported in
Athan G. Dial +8 more
doaj +1 more source
Pancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]
, 2014 Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.
Andrew Eugene Hendifar +8 more
core +2 more sources
Small RNA-Mediated Epigenetic Myostatin Silencing
Molecular Therapy - Nucleic Acids, 2012 Myostatin (Mstn) is a secreted growth factor that negatively regulates muscle mass and is therefore a potential pharmacological target for the treatment of muscle wasting disorders such as Duchenne muscular dystrophy. Here we describe a novel Mstn blockade approach in which small interfering RNAs (siRNAs) complementary to a promoter-associated ...
Roberts, T +4 more
openaire +4 more sources
Assessing the effect of bovine MSTN variants on pre‐mRNA splicing
Animal Genetics, Volume 57, Issue 1, February 2026.Abstract The myostatin protein is a potent negative regulator of skeletal muscle growth encoded by the MSTN gene. MSTN loss‐of‐function variants lead to a particular cattle phenotype characterized by an increase in skeletal muscle mass, known as “double muscling” or “double muscled”.
Nicolas Gaiani +2 more
wiley +1 more source
Ranking of Sire Breeds and Beef Cross Breeding of Dairy and Beef Cows [PDF]
, 2011 End of Project ReportSummary There is general agreement across countries on the ranking of beef breeds for production and carcass traits. Differences between dairy and early maturing beef breeds in growth and slaughter traits are small, but the latter ...
Keane, Michael G.
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