Results 81 to 90 of about 19,108 (217)

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

Metabolic Functions of Myostatin and GDF11 [PDF]

Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry, 2010
Myostatin is a member of the transforming growth factor β superfamily of secreted growth factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have a dramatically increased mass of individual muscles, reduced adiposity, increased insulin sensitivity, and resistance to obesity.
openaire   +2 more sources

Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV) [PDF]

, 2014
Myostatin (Mstn), a member of the transforming growth factor-β super family, is a potent negative regulator of skeletal muscle mass. Studies delineating the function of Mstn have identified multiple signal transduction pathways that convey the Mstn ...
Hennebry, Alex
core  

Musculoskeletal decay and bone–muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures

Experimental Physiology, EarlyView.
Abstract Older adults experience a markedly increased risk of falls and fractures following hospital discharge, largely due to the rapid musculoskeletal deterioration associated with bed rest. Although age‐related muscle and bone loss typically develops gradually, acute physical inactivity accelerates key biological processes underlying sarcopenia and ...
Julia Margarita Reyes, Guy Hajj‐Boutros, Dounia Rouabhia, José Morais, Felipe Salech, Gustavo Duque   +5 more
wiley   +1 more source

Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches [PDF]

, 2017
Muscular dystrophies are characterized by weakness and wasting of skeletal muscle tissues. Several drugs targeting the myostatin pathway have been used in clinical trials to increase muscle mass and function but most showed limited efficacy. Here we show
Joubert, R, Romain Joubert, Machado, Pedro,, Benvensite, O, Muntoni, Francesco, Buj-Bello, Ana, Thomas Voit, Dumonceaux, J, Dumonceaux, Julie, Servais, Laurent, Mariot, Virginie, Voit, T, Thierry Maisonobe, Ana Buj-Bello, Hourdé, C, Le Panse, R, Maisonobe, T, Maisonobe, Thierry, Muntoni, F, Caroline Bogni, Féasson, L, Bogni, C, Francesco Muntoni, Pedro M. Machado, Virginie Mariot, Rozen Le Panse, Michael Hanna, Mariot, V, Buj-Bello, A, Stojkovic, Tanya, Machado, PM, Hanna, Michael, Machado, Pedro, Julie Dumonceaux, Le Panse, Rozen, Servais, L, Benvensite, Olivier, Joubert, Romain, Tanya Stojkovic, Machado, Pedro M., Olivier Benvensite, Voit, Thomas, Léonard Féasson, Christophe Hourdé, Feasson, Leonard, Hanna, M, Laurent Servais, Stojkovic, T, Hourde, Christophe, Bogni, Caroline   +49 more
core   +2 more sources

Temporal and intra-horse consistency of circulating myostatin concentrations in Thoroughbred racehorses

Scientific Reports
In Thoroughbred horses, a highly prevalent short interspersed nuclear element (SINE) mutation in the myostatin gene (MSTN) promoter influences circulating myostatin concentration and is associated with muscle morphology, fracture risk and optimal race ...
Katherine Hanousek, Victoria O’Hara, Dominique O. Riddell, Richard J. Piercy   +3 more
doaj   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Higher serum myostatin levels are associated with lower insulin sensitivity in adults with overweight/obesity

Physiological Reports
Myostatin inhibition improves insulin sensitivity in preclinical and clinical models; however, studies investigating the relationship between serum myostatin levels and insulin sensitivity are discrepant.
Laura E. Dichtel, Allison Kimball, Bryan Bollinger, Geetanjali Scarff, Anu V. Gerweck, Miriam A. Bredella, Melanie S. Haines   +6 more
doaj   +1 more source

MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression

Animal, 2014
MicroRNAs are endogenous ~22nt RNAs that negatively regulate gene expression at the posttranscriptional level via binding to the 3′-untranslated region (3′UTR) of target mRNAs.
T. Yang, X.L. Chen, Z.Q. Huang, W.X. Wen, M. Xu, D.W. Chen, B. Yu, J. He, J.Q. Luo, J. Yu, X.B. Mao, P. Zheng   +11 more
doaj   +1 more source