Results 81 to 90 of about 12,955 (195)

Changes in Muscle Mass and Quality Mediate the Effect of High‐Calorie Intake on Clinical Outcomes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Critically ill patients frequently experienced acquired muscle dysfunction, which adversely affects outcomes. The relationship between calorie intake, muscle dysfunction and outcomes remains unclear. This study aims to determine if early calorie intake affects patients' outcomes through changes in skeletal muscle mass or quality ...
Yassir Aarab, Fabrice Raynaud, Mathieu Capdevila, Aurelien Flatres, Gérald Hugon, Céline Lauret, Nicolas Molinari, Celia Vidal, Kada Klouche, Samir Jaber, Stefan Matecki, Boris Jung   +11 more
wiley   +1 more source

Presurgical miR‐675‐5p Associates With the Inflammatory Response Following Surgery and Increases Inflammatory Gene Expression In Vitro

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background A loss of muscle mass and strength is a marker of poor outcomes following surgery. Changes in muscle gene expression following surgery are likely to contribute to postsurgical muscle loss, but the mechanisms controlling these changes are not known. We have previously shown that miRNAs associate with muscle loss in disease, including
Narmin Akhundova, Richard Paul, Benjamin Fletcher, Martin Connolly, Mark J. Griffiths, Paul R. Kemp   +5 more
wiley   +1 more source

Myostatin antisense administration prevents sepsis‐induced muscle atrophy and weakness in male mice

Physiological Reports
Muscle atrophy and weakness are serious problems associated with sepsis. However, only a few pharmacological interventions are available to date. In this study, myostatin antisense was used to prevent sepsis‐induced muscle atrophy and weakness.
Nobuto Nakanishi, Kazuhiro Maeta, Yuko Ono, Takumi Hirabayashi, Daisuke Tatebayashi, Kensuke Nakamura, Shigeaki Inoue, Masafumi Matsuo, Joji Kotani   +8 more
doaj   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to account for anatomical variation, and may not accurately recapitulate progressive PAD pathophysiology ...
Oliver Kitzerow, Zhiqiu Xia, Samuel Gillman, Iraklis I. Pipinos, Han‐Jun Wang   +4 more
wiley   +1 more source

Myostatin-driven muscle hypertrophy: a double-edged sword in muscle physiology

Journal of Rare Diseases
Myostatin (MSTN), a pivotal regulator of skeletal muscle homeostasis, belongs to the TGF-β family and functions as a potent inhibitor of muscle hypertrophy.
Ghisaram Dewasi, Parikshit Nagda, Gurusha Bahl, Vivek Jain, Sanjay Kumar Gupta   +4 more
doaj   +1 more source

Myostatin Exacerbates Endothelial Dysfunction Induced by Uremic Toxin Indoxyl Sulfate and Is Associated with Hemodialysis Arteriovenous Access Complications

Toxins
Hemodialysis patients exhibit endothelial dysfunction, contributing to elevated cardiovascular risk and complications of the arteriovenous access. These patients have elevated serum levels of myostatin, a member of the transforming growth factor-β (TGFβ)
Justine Solignac, Laetitia Dou, Rania Chermiti, Nathalie McKay, Philippe Giaime, Nathalie Pedinielli, Hamza Benjelloun, Guillaume Lano, Julien Mancini, Stéphane Burtey, Stanislas Bataille   +10 more
doaj   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, Volume 293, Issue 15, Page 4624-4644, August 2026.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source