Results 101 to 110 of about 19,108 (217)

Myostatin antisense administration prevents sepsis‐induced muscle atrophy and weakness in male mice

Physiological Reports
Muscle atrophy and weakness are serious problems associated with sepsis. However, only a few pharmacological interventions are available to date. In this study, myostatin antisense was used to prevent sepsis‐induced muscle atrophy and weakness.
Nobuto Nakanishi, Kazuhiro Maeta, Yuko Ono, Takumi Hirabayashi, Daisuke Tatebayashi, Kensuke Nakamura, Shigeaki Inoue, Masafumi Matsuo, Joji Kotani   +8 more
doaj   +1 more source

Structural Basis for the Effective Myostatin Inhibition of the Mouse Myostatin Prodomain-Derived Minimum Peptide

, 2016
Myostatin inhibition is one of the promising strategies for treating muscle atrophic disorders, including muscular dystrophy. It is well-known that the myostatin prodomain derived from the myostatin precursor acts as an inhibitor of mature myostatin.
Akari Nakamura (3365504), Kentaro Takayama (668079), Yoshio Hayashi (111974), Akihiro Taguchi (1639003), Tomo Asari (1655836), Takahiro Shimada (571669)   +5 more
core   +1 more source

Myostatin Exacerbates Endothelial Dysfunction Induced by Uremic Toxin Indoxyl Sulfate and Is Associated with Hemodialysis Arteriovenous Access Complications

Toxins
Hemodialysis patients exhibit endothelial dysfunction, contributing to elevated cardiovascular risk and complications of the arteriovenous access. These patients have elevated serum levels of myostatin, a member of the transforming growth factor-β (TGFβ)
Justine Solignac, Laetitia Dou, Rania Chermiti, Nathalie McKay, Philippe Giaime, Nathalie Pedinielli, Hamza Benjelloun, Guillaume Lano, Julien Mancini, Stéphane Burtey, Stanislas Bataille   +10 more
doaj   +1 more source

Dex or myostatin can inhibit Akirin1 expression.

, 2013
Satellite cells were treated with different concentrations of Dex for 24 h. A. Akirin-1 mRNA expression was examined by RT-PCR (corrected for GAPDH). The fold change vs.
Liping Zhang (177396), Jenny S. Pan (389083), Yanjun Dong (389082)   +2 more
core   +1 more source

Myostatin-driven muscle hypertrophy: a double-edged sword in muscle physiology

Journal of Rare Diseases
Myostatin (MSTN), a pivotal regulator of skeletal muscle homeostasis, belongs to the TGF-β family and functions as a potent inhibitor of muscle hypertrophy.
Ghisaram Dewasi, Parikshit Nagda, Gurusha Bahl, Vivek Jain, Sanjay Kumar Gupta   +4 more
doaj   +1 more source

Stress and Myostatin in Salmoninae [PDF]

, 2014
The relationship between the muscle growth inhibitor, myostatin, and the stress response has been extensively studied in mammals, and myostatin is now known to partially mediate the degradative effects of stress in skeletal muscle.
Galt, Nicholas
core  

Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin Inhibition

, 2016
Myostatin, an endogenous negative regulator of skeletal muscle mass, is a therapeutic target for muscle atrophic disorders. Here, we identified minimum peptides 2 and 7 to effectively inhibit myostatin activity, which consist of 24 and 23 amino acids ...
Fumiko Itoh (445250), Yoichi Negishi (138848), Kentaro Takayama (668079), Shin Aoki (784647), Fumika Yakushiji (1639009), Yoshio Hayashi (111974), Momoko Yoshida (702687), Yutaka Ohsawa (587120), Shota Takayama (1655833), Tomo Asari (1655836), Yoshihide Sunada (460875), Yuri Noguchi (1655839), Shin-ichiro Nishimatsu (777640)   +12 more
core   +1 more source

Serum level of myostatin and type I interferon-inducible gene expression in dermatomyositis patients and its relation to insulin resistance

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Data regarding the relation between serum myostatin level, type I interferon-inducible gene expression and insulin resistance in dermatomyositis patients are limited.
Rania S. Nageeb, Noura Mostafa Mohamed, Ahmad Sallam Soliman, Amany M. Ebaid, Nancy Abdelhamid Mohammad   +4 more
doaj   +1 more source

Effect of maternal myostatin antibody on offspring growth performance and body composition in mice

, 2012
[[abstract]]Myostatin (GDF8) is a member of the transforming growth factor beta (TGF-beta) superfamily. The finding that animals with a knockout or mutation of the myostatin-encoding gene show increased muscle mass suggests that myostatin negatively ...
Yu-Chuan Liang;Jan-Ying Yeh;Bor-Rung Ou
core  

The Myostatin Gene [PDF]

, 2009
Myostatin is an important negative regulator of muscle growth. Natural mutations and knockouts in animals produce a “double-muscled” phenotype the basis of which is a dramatic increase in muscle mass. Therapeutics that target myostatin are currently in
Weiner, Geoffrey
core