Results 111 to 120 of about 33,582 (263)

Healthy community‐living older men differ from women in associations between myostatin levels and skeletal muscle mass

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background Myostatin is a negative regulator of muscle growth but the relationship between serum myostatin levels and muscle mass is unclear. This study investigated the association between serum myostatin levels and skeletal muscle mass among healthy ...
Li‐Ning Peng, Wei‐Ju Lee, Li‐Kuo Liu, Ming‐Hsien Lin, Liang‐Kung Chen   +4 more
doaj   +1 more source

Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy

BMC Medical Genomics, 2011
Background Myostatin is a potent muscle growth inhibitor that belongs to the Transforming Growth Factor-β (TGF-β) family. Mutations leading to non functional myostatin have been associated with hypermuscularity in several organisms. By contrast, Duchenne
van Ommen Gert Jan B, den Dunnen Johan T, de Gorter David JJ, Terlouw Samuel, van Heiningen Sandra H, Hoogaars Willem MH, Kemaladewi Dwi U, Aartsma-Rus Annemieke, ten Dijke Peter, 't Hoen Peter AC   +9 more
doaj   +1 more source

Combined sanger and ngs sequence analysis of the myostatin gene (mstn) in the Camelus dromedarius species [PDF]

, 2015
Different mutations have been identified in the myostatin gene (MSTN), some of which are responsible for protein inactivation and double muscling phenotype in mammals.
Burger, P., Cherifi, Y., Ciani, Elena, Faye, Bernard, Fitak, Robert Rodgers, Lacalandra, G.M., Muzzachi, S., Oulmouden, A., Yahyaoui, H., Zayed, M.A.   +9 more
core  

Micro-RNAS that control myosin expression and myofiber identity [PDF]

, 2015
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber
Olson, Eric N., van Rooij, Eva
core   +1 more source

The role of CXCL10 in high‐fat diet–induced skeletal muscle inflammation and atrophy

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Obesity is often accompanied by skeletal muscle atrophy, which aggravates insulin resistance and metabolic dysfunction. Chronic inflammation is implicated in this process, but the molecular mediators linking obesity‐induced inflammation to muscle wasting have remained unclear.
An Liyuan, Yu Hirata, Tomoya Inoue, Kenji Sugawara, Wataru Ogawa   +4 more
wiley   +1 more source

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.

Cell Metabolism, 2018
Skeletal muscle and brown adipose tissue (BAT) are functionally linked, as exercise increases browning via secretion of myokines. It is unknown whether BAT affects muscle function. Here, we find that loss of the transcription factor IRF4 in BAT (BATI4KO)
X. Kong, Ting Yao, P. Zhou, L. Kazak, Danielle E. Tenen, A. Lyubetskaya, Brian A. Dawes, Linus T. Tsai, B. Kahn, B. Spiegelman, Tiemin Liu, E. Rosen   +11 more
semanticscholar   +1 more source

High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2 [PDF]

, 2018
Myotonic dystrophy type 1 (DM1) is a multi-systemic disorder caused by abnormally expanded stretches of CTG DNA triplets in the DMPK gene, leading to mutated-transcript RNA-toxicity.
Cappella, Marisa, Cardani, Rosanna, Cardinali, Beatrice, Carrara, Matteo, Fabio Martelli, And, Falcone, Germana, Fuschi, Paola, Manuel Garcia-Manteiga, Jose, Meola, Giovanni, Perfetti, Alessandra, Provenzano, Claudia, Valentina Renna, Laura   +11 more
core   +2 more sources

Endocrine‐Nutritional Synergy Between Sex Inversion and Microencapsulated Bioactives Enhances Growth, Intestinal Development, and Oxidative Stability in Nile Tilapia Larvae

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study evaluated the combined effects of sex inversion and microencapsulated supplementation with organic acids and essential oils on growth performance, tissue morphology, gene expression, and oxidative status in Nile tilapia (Oreochromis niloticus) larvae.
Jaísa Casetta, Eliane Gasparino, Caroline Isabela da Silva, Simone Siemer, Gabriela Hernandes Cangianelli, Ricardo Souza Vasconcellos, Ricardo Pereira Ribeiro, Graciele Caroline Mari, Jaqueline Roesler, Juliana Sofientini, Diogo de Oliveira Marques, Stefania Claudino‐Silva   +11 more
wiley   +1 more source

AAV-mediated administration of myostatin pro-peptide mutant in adult Ldlr null mice reduces diet-induced hepatosteatosis and arteriosclerosis. [PDF]

PLoS ONE, 2013
Genetic disruption of myostatin or its related signaling is known to cause strong protection against diet-induced metabolic disorders. The translational value of these prior findings, however, is dependent on whether such metabolically favorable ...
Wen Guo, Siu Wong, Shalender Bhasin
doaj   +1 more source

Locomotor muscle dysfunction and rehabilitative exercise training in fibrotic interstitial lung disease: Where are we at and where could we go?

Experimental Physiology, EarlyView.
Abstract Exercise limitation is a cardinal feature of fibrotic interstitial lung disease arising from pulmonary gas exchange, respiratory mechanical and cardio‐circulatory abnormalities. More recently, it has been recognized that impairment in locomotor muscle function (e.g., reduced muscle mass/strength or heightened fatigability) might also play a ...
Sarah Thivent, J. Alberto Neder, Anne‐Catherine Bernard, Marie Coudurier, Michel Guinot, Frédéric Hérengt, Samuel Verges, Mathieu Marillier   +7 more
wiley   +1 more source