Results 111 to 120 of about 26,633 (217)

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

Higher serum myostatin levels are associated with lower insulin sensitivity in adults with overweight/obesity

Physiological Reports
Myostatin inhibition improves insulin sensitivity in preclinical and clinical models; however, studies investigating the relationship between serum myostatin levels and insulin sensitivity are discrepant.
Laura E. Dichtel, Allison Kimball, Bryan Bollinger, Geetanjali Scarff, Anu V. Gerweck, Miriam A. Bredella, Melanie S. Haines   +6 more
doaj   +1 more source

Does Myostatin Induce Insulin Resistance?

Journal of Biological Chemistry, 2014
Bonala et al. (1) report that high glucose or fat increases myostatin protein expression in muscle and surprisingly liver (cells and tissue) and that myostatin induces insulin resistance. Their myostatin antiserum used for Western blotting and possibly ELISAs (not discussed) recognizes a reported 26-kDa protein under reducing conditions despite a ...
openaire   +2 more sources

High‐ and Low‐Protein Maternal Diet During Pregnancy Alter the Offspring Skeletal Muscle Transcriptome and miRNAome in Lamb

New Zealand Journal of Agricultural Research, Volume 69, Issue 1, February 2026.
Maternal nutrition during gestation is a crucial factor affecting offspring development. This study explores the impact of maternal dietary protein levels on the transcriptome and miRNAome of skeletal muscle in lambs. Twelve Akkaraman breed ewes were assigned to three dietary groups—standard (SP, 119–198 g/day), high (HP, 160–270 g/day), and low (LP ...
Bilal Akyüz, Md Mahmodul Hasan Sohel, Yusuf Konca, Korhan Arslan, Kutlay Gürbulak, Murat Abay, Mahmut Kaliber, Stephen N. White, Mehmet Ulas Cinar   +8 more
wiley   +1 more source

Baseline Muscle Mass Is a Poor Predictor of Functional Overload-Induced Gain in the Mouse Model [PDF]

, 2016
This research was funded by the European Social Fund under the Global Grant measure.
Bunger, L, Kilikevicius, A, Lionikas, Arimantas   +2 more
core   +2 more sources

Risk Factors Associated With Sarcopenia in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenia is an age‐related degenerative disorder characterized by a progressive decline in skeletal muscle mass, strength, and function with high prevalence in chronic kidney disease (CKD). Identifying clinical and epidemiological factors of sarcopenia in patients with CKD is essential to enable early recognition and appropriate ...
Kaili Jin, Xiaoyan Li, Yiqin Ma, Dan Yang, Xiaoxue Tan, Qiuhua Sun, Rongyun Wang   +6 more
wiley   +1 more source

Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation [PDF]

, 2017
Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin-interacting factors is relatively under examined in older males ...
Amthor, Bell, Bowling, Cassidy, Drummond, Egerman, Elliott, Elliott, Gilson, Gonzalez-Cadavid, Grace, Hayes, Hayes, Hayes, Herbert, Herbert, Herbert, Hill, Horrington, Kambadur, Knowles, Lee, Lunsford, Metter, Mosher, Pollock, Pugh, Ramos, Ratkevicius, Roth, Rowe, Saremi, Sculthorpe, Shiraev, Sinha, Thum, Walker, Walker, Whittemore, Yarasheski, Zhou, Zimmers   +41 more
core   +3 more sources

Peptide OH‐CATH30 Mitigates Cachexia‐Induced Muscle Atrophy via Modulation of TLR4‐Associated Inflammation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Cachexia, characterized by severe weight loss and muscle atrophy, frequently occurs in chronic conditions such as sepsis, cancer and chemotherapy, with limited effective treatments. Despite similar clinical manifestations, the underlying mechanisms across different disease contexts remain unclear.
Qiquan Wang, Jian Li, Mengqi Yang, Caifen Guo, Ming Zhang, Chunping Huang, Xiang Wang, Dongqin Zhang, Lin Zeng, Hao Ke, Yunling Wen, Shengan Li, Wenhui Lee, Limin Zhao, Xinqiang Lan, Yang Xiang   +15 more
wiley   +1 more source

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]

, 2019
BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Dong, Jiangling, Garibotto, Giacomo, Hruska, Keith, Hu, Zhaoyong, Mitch, William E, Thomas, Sandhya S, Verzola, Daniela, Wu, Jiao   +7 more
core   +2 more sources

Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Excess adiposity is a major risk factor for insulin resistance, prediabetes, and Type 2 diabetes and increases the risk for sarcopenia and osteosarcopenia later in life. It has been proposed that altered metabolic function and musculoskeletal status in people with obesity are directly linked, presumably because they share common ...
Alan Fappi, Clifton J. Holmes, Chao Cao, Vasavi Shabrish, Aman P. Aher, Karen Shen, Paul K. Commean, Dwight A. Towler, Dominic N. Reeds, Gretchen A. Meyer, Bettina Mittendorfer   +10 more
wiley   +1 more source