Results 131 to 140 of about 33,582 (263)

Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Myostatin and activin A are secreted signaling molecules that act to limit skeletal muscle growth. Here, we show that myostatin and activin A utilize four receptor components to signal directly to muscle fibers.
Se-Jin Lee, A. Lehar, Yewei Liu, Chi Ly, Quynh-Mai Pham, M. Michaud, Renata Rydzik, D. Youngstrom, M. Shen, V. Kaartinen, Emily L. Germain-Lee, T. Rando   +11 more
semanticscholar   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression

Animal, 2014
MicroRNAs are endogenous ~22nt RNAs that negatively regulate gene expression at the posttranscriptional level via binding to the 3′-untranslated region (3′UTR) of target mRNAs.
T. Yang, X.L. Chen, Z.Q. Huang, W.X. Wen, M. Xu, D.W. Chen, B. Yu, J. He, J.Q. Luo, J. Yu, X.B. Mao, P. Zheng   +11 more
doaj   +1 more source

Neuromuscular magnetic stimulation counteracts muscle decline in ALS patients: results of a randomized, double-blind, controlled study [PDF]

, 2019
The aim of the study was to verify whether neuromuscular magnetic stimulation (NMMS) improves muscle function in spinal-onset amyotrophic lateral sclerosis (ALS) patients.
Cambieri, Chiara, Ceccanti, Marco, Cerbelli, Bruna, Cifelli, Pierangelo, Cristina Gori, Maria, Dobrowolny, Gabriella, Frasca, Vittorio, Giordano, Carla, Inghilleri, Maurizio, Lepore, Elisa, Musaro', Antonio, Onesti, Emanuela, Palma, Eleonora, Pisano, Annalinda, Roseti, Cristina, Ruffolo, Gabriele   +15 more
core   +1 more source

Novel myostatin-specific antibody enhances muscle strength in muscle disease models

Scientific Reports, 2020
Myostatin, a member of the transforming growth factor-β superfamily, is an attractive target for muscle disease therapy because of its role as a negative regulator of muscle growth and strength.
H. Muramatsu, Taichi Kuramochi, H. Katada, Atsunori Ueyama, Y. Ruike, K. Ohmine, Meiri Shida-Kawazoe, Rie Miyano-Nishizawa, Yuichiro Shimizu, Momoko Okuda, Y. Hori, Madoka Hayashi, K. Haraya, N. Ban, T. Nonaka, Masaki Honda, H. Kitamura, K. Hattori, T. Kitazawa, T. Igawa, Y. Kawabe, J. Nezu   +21 more
semanticscholar   +1 more source

Small RNA-Mediated Epigenetic Myostatin Silencing

Molecular Therapy - Nucleic Acids, 2012
Myostatin (Mstn) is a secreted growth factor that negatively regulates muscle mass and is therefore a potential pharmacological target for the treatment of muscle wasting disorders such as Duchenne muscular dystrophy. Here we describe a novel Mstn blockade approach in which small interfering RNAs (siRNAs) complementary to a promoter-associated ...
Roberts, T, Andaloussi, SE, Morris, K, McClorey, G, Wood, M   +4 more
openaire   +4 more sources

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. [PDF]

, 2019
IntroductionDysferlin loss-of-function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin-like growth factor 1 (IGF-1) could provide benefit but may cause ...
Barton, Elisabeth R, Brisson, Becky K, Hammers, David W, Liu, Min, Park, SooHyun, Pham, Jennifer, Smith, Lucas R, Sweeney, H Lee, Tian, Zuozhen, Vassilakos, Georgios   +9 more
core   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Higher serum myostatin levels are associated with lower insulin sensitivity in adults with overweight/obesity

Physiological Reports
Myostatin inhibition improves insulin sensitivity in preclinical and clinical models; however, studies investigating the relationship between serum myostatin levels and insulin sensitivity are discrepant.
Laura E. Dichtel, Allison Kimball, Bryan Bollinger, Geetanjali Scarff, Anu V. Gerweck, Miriam A. Bredella, Melanie S. Haines   +6 more
doaj   +1 more source