Results 141 to 150 of about 33,582 (263)

Does Myostatin Induce Insulin Resistance?

Journal of Biological Chemistry, 2014
Bonala et al. (1) report that high glucose or fat increases myostatin protein expression in muscle and surprisingly liver (cells and tissue) and that myostatin induces insulin resistance. Their myostatin antiserum used for Western blotting and possibly ELISAs (not discussed) recognizes a reported 26-kDa protein under reducing conditions despite a ...
openaire   +2 more sources

The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background Liver‐related sarcopenia is a devastating systemic complication of chronic liver disease (CLD) driven by mechanisms extending beyond nutritional deficiency. However, the role of liver‐derived humoral factors remains unclear. We utilised a unique cohort of human skeletal muscle biopsies to test the hypothesis that serum conjugated ...
Motoh Iwasa, Akiko Eguchi, Motoyuki Kohjima, Teruo Miyazaki, Hiroshi Kitamura, Yuko Takami, Naoki Yamashita, Mina Tempaku, Kiyora Izuoka, Yoshinao Kobayashi, Yoshiyuki Takei, Akira Honda, Hayato Nakagawa, Tadashi Ikegami, Makoto Nakamuta, Jun Okabe, Aldo J. Montano‐Loza   +16 more
wiley   +1 more source

Muscle and serum myostatin expression in type 1 diabetes

Physiological Reports, 2020
Type 1 diabetes (T1D) has been reported to negatively affect the health of skeletal muscle, though the underlying mechanisms are unknown. Myostatin, a myokine whose increased expression is associated with muscle‐wasting diseases, has not been reported in
Athan G. Dial, Cynthia M. F. Monaco, Grace K. Grafham, Nadya Romanova, Jeremy A. Simpson, Mark A. Tarnopolsky, Christopher G. R. Perry, Evangelia Kalaitzoglou, Thomas J. Hawke   +8 more
doaj   +1 more source

Circulating myostatin is reduced with aging in humans but not altered by short-term, high intensity training [PDF]

, 2016
Introduction: Ageing involves a loss of muscle mass and function. The rate of decline is associated with negative health outcomes and increased mortality (1).
Altayar, Z., Altayar, Z., Barrios, L., Barrios, L., Chaudhary, G.A., Chaudhary, G.A., Elliott, B., Elliott, B., Grace, F., Grace, F., Hanifa, E., Hanifa, E., Hayes, L., Hayes, L., Herbert, P., Herbert, P., Parnell, M., Parnell, M., Sculthorpe, N., Sculthorpe, N., Shinwari, Z.B., Shinwari, Z.B., Xenofontos, T., Xenofontos, T.   +23 more
core  

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]

, 2019
BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Dong, Jiangling, Garibotto, Giacomo, Hruska, Keith, Hu, Zhaoyong, Mitch, William E, Thomas, Sandhya S, Verzola, Daniela, Wu, Jiao   +7 more
core   +2 more sources

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Myoblast models of skeletal muscle hypertrophy and atrophy [PDF]

, 2011
Purpose of review: To highlight recent breakthroughs and controversies in the use of myoblast models to uncover cellular and molecular mechanisms regulating skeletal muscle hypertrophy and atrophy.
Amthor, Amthor, Anthony, Anthony, Armstrong, Castro-Gago, Chen, Dennis, DeYoung, Drummond, Findlay, Florini, Foulstone, Gentile, Glass, Heron-Milhavet, Hornberger, Jacquemin, Katagiri, Langen, Lee, Lee, Lee, Lee, Leger, Matheny, McCarthy, McFarlane, McFarlane, McPherron, McPherron, Morgan, Mudera, OʼNeil, Peng, Quinn, Rebbapragada, Rios, Saini, Sartori, Sasai, Schultz, Scime, Sharples, Spangenburg, Stewart, Stewart, Stewart, Sun, Tatsumi, Trendelenburg, Tsuchida, Wagner, Welle, Whittemore, Yamada   +55 more
core   +2 more sources

Maternal Undernutrition Alters Fetal Muscle Growth, Metabolism, and Transcriptomic Regulation in Intrauterine Growth Restricted Sheep

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Maternal undernutrition in late pregnancy restricts fetal skeletal muscle growth and shifts muscle fiber types to fast muscle types. These changes are driven by changes in mitochondrial enzymes and DNA, endoplasmic reticulum stress, and ribosomal activity that predispose postnatal offspring to metabolic disorders.
Yina Qiao, Yilin Yang, Yang Zi, Chi Ma, Min Zhang, Xusheng Hao, Yingchun Liu, Feng Gao   +7 more
wiley   +1 more source

A Systematic Review and User Reference of Phenotypic and Molecular Characteristics of Dexamethasone‐Mediated C2C12 Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Skeletal muscle is a vital part of human physiology and is responsible for numerous essential functions. Not surprisingly, the loss of skeletal muscle mass and function is common in several pathologies including atrophy and sarcopenia, which profoundly impact quality of life of those afflicted.
Alexa J. Klein, Roger A. Vaughan
wiley   +1 more source

Downregulation of Organ‐Derived Activin A Attenuates Muscle Atrophy and Intramuscular Fat Infiltration in Cancer Cachexia Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cancer cachexia is a multifactorial wasting syndrome marked by profound skeletal muscle loss. Tumours can release high levels of Activin A (ActA), which activates the ubiquitin‐proteasome pathway (UPP) and drives muscle wasting.
Cui Wang, Lin Gao, Rui Xue, Jia Su, Honghui Li, Wei Yang, Yan Tang, Zhihang Su, Shasha Min, Changyong Tang, Yuqi Zhu, Bo Mu, John R. Speakman, Xina Xie, Zesong Li   +14 more
wiley   +1 more source