Results 81 to 90 of about 26,633 (217)

Roles of mechanistic target of rapamycin and transforming growth factor-B signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis [PDF]

, 2016
Molting in decapod crustaceans is controlled by molt-inhibiting hormone (MIH), an eyestalk neuropeptide that suppresses production of ecdysteroids by a pair of molting glands (Y-organs or YOs). Eyestalk ablation (ESA) activates the YOs, which hypertrophy
Abuhagr, Ali M., Chang, Ernest S., Chang, Sharon A., MacLea, Kyle S., Mudron, Megan R., Mykles, Donald L.   +5 more
core   +2 more sources

SEPSIS DOWNREGUALTES MYOSTATIN mRNA LEVELS WITHOUT ALTERING MYOSTATIN PROTEIN LEVELS IN SKELETAL MUSCLE

The FASEB Journal, 2010
Myostatin is a negative regulator of muscle mass and has been reported to be upregulated in several conditions characterized by muscle atrophy. The influence of sepsis on myostatin expression and activity is poorly understood.
Ira J, Smith, Zaira, Aversa, Nima, Alamdari, Victoria, Petkova, Per-Olof, Hasselgren   +4 more
openaire   +2 more sources

Impact of obesity and an obesogenic environment on cardiotoxin‐induced damage and recovery of human myotubes

Experimental Physiology, EarlyView.
Abstract Obesity (BMI ≥ 30 kg/m2) reduces skeletal muscle quality and impairs the myogenic response to muscle damage. The present study investigated if differences exist in myotubes from individuals with (OB) or without (LN) obesity incubated in control (bovine serum albumin [BSA]) or obesogenic (Ob) medium, at baseline or in response to cardiotoxin ...
Brian P. Sullivan, Lundon C. Burton, Allison Ellis, Christopher K. Kargl, Deborah Shera, Shihuan Kuang, James F. Markworth, Timothy P. Gavin   +7 more
wiley   +1 more source

Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats [PDF]

, 2015
Myostatin is a negative regulator of skeletal muscle and tendon mass. Myostatin deficiency has been well studied in mice, but limited data are available on how myostatin regulates the structure and function of muscles and tendons of larger animals.
Davis, Carol S., Flood, Michael D., Gumucio, Jonathan P., Lynch, Evan B., Mendias, Christopher L., Pelt, Douglas W., Rittman, Danielle S., Roche, Stuart M.   +7 more
core   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy

BMC Medical Genomics, 2011
Background Myostatin is a potent muscle growth inhibitor that belongs to the Transforming Growth Factor-β (TGF-β) family. Mutations leading to non functional myostatin have been associated with hypermuscularity in several organisms. By contrast, Duchenne
van Ommen Gert Jan B, den Dunnen Johan T, de Gorter David JJ, Terlouw Samuel, van Heiningen Sandra H, Hoogaars Willem MH, Kemaladewi Dwi U, Aartsma-Rus Annemieke, ten Dijke Peter, 't Hoen Peter AC   +9 more
doaj   +1 more source

Adeno-associated virus-8-Mediated intravenous transfer of myostatin propeptide leads to systemic functional improvements of slow but not fast muscle [PDF]

, 2009
Myostatin is a member of the transformating growth factor-_ (TGF-_) superfamily of proteins and is produced almost exclusively in skeletal muscle tissue, where it is secreted and circulates as a serum protein.
Bickham, D, Curtin, N A, Dickson, G, Foster, H, Foster, K, Graham, I R, Kawar, S L, Otto, A, Patel, K, Royal Holloway, Trollet, C, Walsh, F S, Yaworsky, P J   +12 more
core   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

AAV-mediated administration of myostatin pro-peptide mutant in adult Ldlr null mice reduces diet-induced hepatosteatosis and arteriosclerosis. [PDF]

PLoS ONE, 2013
Genetic disruption of myostatin or its related signaling is known to cause strong protection against diet-induced metabolic disorders. The translational value of these prior findings, however, is dependent on whether such metabolically favorable ...
Wen Guo, Siu Wong, Shalender Bhasin
doaj   +1 more source

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication [PDF]

, 2017
Muscle and bone are closely associated in both anatomy and function, but the mechanisms that coordinate their synergistic action remain poorly defined. Myostatin, a myokine secreted by muscles, has been shown to inhibit muscle growth, and the disruption ...
Bauman, William A., Bonewald, Lynda F., Cardozo, Christopher, Divieti Pajevic, Paola, Ksiezak-Reding, Hanna, Pan, Jianping, Peng, Yuanzhen, Qin, Weiping, Qin, Yiwen, Wu, Yingjie, Zhao, Wei   +10 more
core   +1 more source