Results 101 to 110 of about 2,019 (200)

Image9_Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom.JPEG

, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Thomas J. D. Jørgensen (8862011), Bruno Lomonte (181809), Borries Demeler (431852), Barbara S. Soares (12008543), Viviane A. Bastos (12008549), Ana Gisele C. Neves-Ferreira (5916077), Tayler L. Williams (5118065), Amy Henrickson (8997298), Jonas Perales (158987), Janelle Arnold (12008552), Francisco Gomes-Neto (1615534), Richard H. Valente (158989), Diogo B. Lima (1903639), Tatiana A. C. B. Souza (12008555), Surza Lucia G. Rocha (12008546), Paulo C. Carvalho (1590364), Fabio C. Gozzo (104392)   +16 more
core   +1 more source

Image5_Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom.JPEG

, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Thomas J. D. Jørgensen (8862011), Bruno Lomonte (181809), Borries Demeler (431852), Barbara S. Soares (12008543), Viviane A. Bastos (12008549), Ana Gisele C. Neves-Ferreira (5916077), Tayler L. Williams (5118065), Amy Henrickson (8997298), Jonas Perales (158987), Janelle Arnold (12008552), Francisco Gomes-Neto (1615534), Richard H. Valente (158989), Diogo B. Lima (1903639), Tatiana A. C. B. Souza (12008555), Surza Lucia G. Rocha (12008546), Paulo C. Carvalho (1590364), Fabio C. Gozzo (104392)   +16 more
core   +1 more source

Quantitation of myonecrosis induced by myotoxin a from prairie rattlesnake (Crotalus viridis viridis) venom

, 1982
Using a pure myotoxin (myotoxin a) isolated from prairie rattlesnake Crotalus viridis viridis) venom, a comparison between two methods for quantitating myonecrosis in mice was made.
Ownby, Charlotte L., Odell, George V., Colberg, Terry R., Gutiérrez, José María   +3 more
core   +1 more source

Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer

, 1986
A myotoxin from the venom of the snake Bothrops nummifer was purified to homogeneity by ion-exchange chromatography on CM-Sephadex. The toxin is a basic dimer with a subunit molecular weight of 16,000, as estimated by SDS-polyacrylamide gel ...
Cerdas Fallas, Luis, Lomonte, Bruno, Gutiérrez, José María   +2 more
core   +1 more source

Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4)

Skeletal Muscle
Background Insulin resistance and type 2 diabetes impair cellular regeneration in multiple tissues including skeletal muscle. The molecular basis for this impairment is largely unknown.
Tyler J. Sermersheim, LeAnna J. Phillips, Parker L. Evans, Barbara B. Kahn, Steven S. Welc, Carol A. Witczak   +5 more
doaj   +1 more source

Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica

, 1989
The mode of action of a basic myotoxin isolated from Bothrops nummifer venom was studied. This myotoxin is a basic polypeptide of 13,000 mol.wt, with a high content of lysine and aspartate, as well as of hydrophobic amino acids.
Schosinsky Nevermann, Karl, Lomonte, Bruno, Camacho Mora, Zianne, Gutiérrez, José María, Chaves Mora, Fernando, Gené, José Antonio   +5 more
core   +1 more source

Immunohistochemical demonstration of the binding of bothrops asper myotoxin to skeletal muscle sarcolemma

, 1987
The binding of Bothrops asper myotoxin to mouse skeletal muscle was studied at both the light and electron microscope levels using the peroxidase anti-peroxidase technique. The toxin binds to muscle cell sarcolemma, and there are no intracellular binding
Lomonte, Bruno, Gutiérrez, José María, Brenes Pino, Fernando   +2 more
core   +1 more source

Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes

, 1987
The distribution of 125I-labelled Bothrops asper myotoxin following i.m. and i.v. injections was studied in mice. After i.m. administration the toxin was concentrated in the injected gastrocnemius muscle, with relatively little binding to other tissues ...
Moreno Robles, Edgardo, Moreno, Edgardo, José María Gutiérrez, Gutiérrez, José María   +3 more
core   +1 more source

Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A₂ ex vivo does not involve a direct action on the contractile apparatus. [PDF]

Pflugers Arch, 2023
López-Dávila AJ, Weber N, Nayak A, Fritz L, Moustafa KR, Gand LV, Wehry E, Kraft T, Thum T, Fernández J, Gutiérrez JM, Lomonte B.   +11 more
europepmc   +1 more source

In Vivo Neutralization of Myotoxin II, a Phospholipase A₂ Homologue from Bothrops asper Venom, Using Peptides Discovered via Phage Display Technology. [PDF]

ACS Omega, 2022
Laustsen AH, Gless BH, Jenkins TP, Meyhoff-Madsen M, Bjärtun J, Munk AS, Oscoz S, Fernández J, Gutiérrez JM, Lomonte B, Lohse B.   +10 more
europepmc   +1 more source