Results 91 to 100 of about 2,993 (188)

The Dual Role of Exosomes in the Tumor Microenvironment: From Pro‐Tumorigenic Signaling to Immune Modulation

Med Research, Volume 1, Issue 2, Page 257-284, September 2025.
Tumor‐derived exosomes influence proliferation, invasion, angiogenesis, metabolic adaptation, and resistance to therapy. They also shape the immune landscape by modulating antigen presentation, suppressing cytotoxic lymphocyte activity, and promoting the expansion of immunosuppressive cell populations. Although frequently associated with immune evasion,
Jiale Li, Jun Peng, Jiachong Wang, Zigui Chen   +3 more
wiley   +1 more source

Inactivating the lipid kinase activity of PI3KC2β is sufficient to rescue myotubular myopathy in mice

JCI Insight, 2023
Phosphoinositides (PIs) are membrane lipids that regulate signal transduction and vesicular trafficking. X-linked centronuclear myopathy (XLCNM), also called myotubular myopathy, results from loss-of-function mutations in the MTM1 gene, which encodes the
Xènia Massana-Muñoz, Marie Goret, Vasugi Nattarayan, David Reiss, Christine Kretz, Gaetan Chicanne, Bernard Payrastre, Bart Vanhaesebroeck, Jocelyn Laporte   +8 more
doaj   +1 more source

Myotubularin Related Protein 7, a Novel Stim1 Binding Protein

Canadian Journal of Physiology and Pharmacology
Stromal interaction molecule 1 (STIM1) is a Ca2+ sensor in the endoplasmic reticulum (ER) membrane. The protein plays a crucial role in store-operated Ca2+ entry (SOCE) by transducing ER Ca2+ depletion signals to Ca2+ release-activated Ca2+ channel protein 1 (ORAI1) at the plasma membrane.
Ning Dai, Jody Groenendyk, Marek Michalak   +2 more
openaire   +2 more sources

Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1 [PDF]

, 2017
Mutations in the gene encoding myotubularin-related protein 2 (MTMR2) are responsible for autosomal recessive Charcot-Marie-Tooth disease type 4B1 (CMT4B1), a severe hereditary motor and sensory neuropathy characterized by focally folded myelin sheaths ...
Bonneick, Sonja, Berger, Philipp, Suter, Ueli, Willi, Susan, Wymann, Matthias   +4 more
core  

The myotubularin MTMR4 regulates phagosomal phosphatidylinositol 3-phosphate turnover and phagocytosis [PDF]

, 2019
Macrophage phagocytosis is required for effective clearance of invading bacteria and other microbes. Coordinated phosphoinositide signaling is critical both for phagocytic particle engulfment and subsequent phagosomal maturation to a degradative ...
Sriratana, Absorn, Dyson, Jennifer M., Jepsen, Malene R., Mitchell, Christina A., Feeney, Sandra J., Naughtin, Monica J., Bertucci, Micka C., Sheffield, David A., Coppel, Ross L.   +8 more
core   +1 more source

Myotubularin-MTMR12 interactions in XLMTM.

, 2013
(A) Schematic diagram of different domains of myotubularin protein displaying representative pathogenic mutations found in XLMTM patients or an artificial inactivating mutation C375S* (GRAM, N terminal lipid or protein interacting domain; RID, putative ...
Karim Hnia (127778), Stacey R. Gundry (424531), Laura L. Smith (424530), Ethan A. Talbot (424535), Nathaniel E. Goldman (424536), Vandana A. Gupta (142475), Jocelyn Laporte (127789), Junko Shimazu (424533), Leonela Amoasii (127770), Jessica R. Bass (424534), Alan H. Beggs (142493), Jessica E. McIntire (424532)   +11 more
core   +1 more source

LINF_120008300

, 2021
Myotubularin-related protein; Leishmania ...
Requena, J (via Mendeley Data)
core   +1 more source

Interaction between human myotubularin proteins MTMR6 and MTMR9

The FASEB Journal, 2006
Human MTMR6 and MTMR9 are members of a large family of phosphatidylinositol 3‐phosphatases (currently 14 members identified) associated with myotubular myopathy and Charcot Marie Tooth syndrome. MTMR6 is enzymatically active with phosphatidylinositol‐3‐phosphate and phosphatidylinositol‐3,5‐bisphosphate as substrates; MTMR9 is enzymatically inactive ...
Shao‐Chun Chang, Jun Zou, Philip W. Majerus   +2 more
openaire   +1 more source

Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2.

, 2000
A gene mutated in Charcot-Marie-Tooth disease type 4B (CMT4B), an autosomal recessive demyelinating neuropathy with myelin outfoldings, has been mapped on chromosome 11q22.
DEVOTO, MARCELLA, Anthony P. Monaco, Georgiou DM, Schenone A, Alessandra Bolino, Angelo Schenone, Gambardella A, Christodoulou K, MANDICH, PAOLA, Muglia M, Franco Bono, Aldo Quattrone, Domna-Maria Georgiou, Salih MA, Marcella Devoto, SCHENONE, ANGELO, Mustafa A.M. Salih, Paola Mandich, Conforti FL, Hausmanowa Petrusewicz I, Devoto M, LeGuern E, Christodoulou RK, Antonio Gambardella, Francesca Luisa Conforti, Monaco AP, Eric LeGuern, Kyproula Christodoulou, Bolino A, Salih MAM, Maria Muglia, Mandich P, Bono F, Quattrone A, Hausmanowa-Petrusewicz I, Irena Hausmanowa-Petrusewicz   +35 more
core   +2 more sources

Myotubularin and PtdIns3P alterations in mtmr12 morphants.

, 2013
(A) Immunofluorescence of control and mtmr12 knockdown fish showed significantly decreased myotubularin staining in mtmr12 knockdown fish in images taken under identical conditions.
Karim Hnia (127778), Stacey R. Gundry (424531), Laura L. Smith (424530), Ethan A. Talbot (424535), Nathaniel E. Goldman (424536), Vandana A. Gupta (142475), Jocelyn Laporte (127789), Junko Shimazu (424533), Leonela Amoasii (127770), Jessica R. Bass (424534), Alan H. Beggs (142493), Jessica E. McIntire (424532)   +11 more
core   +1 more source