Results 51 to 60 of about 2,993 (188)
Myotubularin-Related Phosphatase 3 Promotes Growth of Colorectal Cancer Cells
The Scientific World Journal, 2014 Due to changes in lifestyle, particularly changes in dietary habits, colorectal cancer (CRC) increased in recent years despite advances in treatment. Nearly one million new cases diagnosed worldwide and half a million deaths make CRC a leading cause of ...
Bo’an Zheng, Xiaojun Yu, Rui Chai
doaj +1 more source
Frontiers in Neuroscience, 2019 Charcot-Marie-Tooth type 4 (CMT4) is an autosomal recessive severe form of neuropathy with genetic heterogeneity. CMT4B1 is caused by mutations in the myotubularin-related 2 (MTMR2) gene and as a member of the myotubularin family, the MTMR2 protein is ...
Haicui Wang +35 more
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Nature Communications, 2023 Exosomes are secreted to the extracellular milieu when multivesicular endosomes (MVEs) dock and fuse with the plasma membrane. However, MVEs are also known to fuse with lysosomes for degradation.
Di-Ao Liu +11 more
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Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt [PDF]
Cell Death & Disease, 2020 AbstractCardiac hypertrophy (CH) is an independent risk factor for many cardiovascular diseases, and is one of the primary causes of morbidity and mortality in elderly people. Pathological CH involves excessive protein synthesis, increased cardiomyocyte size, and ultimately the development of heart failure. Myotubularin-related protein 14 (MTMR14) is a
Zhang, Jie-Lei +9 more
openaire +2 more sources
Targeting PIKfyve: Chemical Biology and Drug Discovery Insights
Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.PIKfyve inhibitors have progressed from niche chemical probes to powerful tools for interrogating endolysosomal biology, enabled by rapid and robust cellular phenotypes. Compounds such as apilimod establish PIKfyve as a druggable lipid kinase, while agents like vacuolin‐1 underscore the importance of distinguishing true target engagement from ...
Athavan Alias Anand Selvam +1 more
wiley +1 more source
Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23
, 2001 Myotubularin and myotubularin-related proteins are dual-specificity phosphatases. Several myotubularin-related proteins have been identified in humans and mice.
Reis, A. +5 more
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AAV-Mediated Intramuscular Delivery of Myotubularin Corrects the Myotubular Myopathy Phenotype in Targeted Murine Muscle and Suggests a Function in Plasma Membrane Homeostasis [PDF]
, 2008 Myotubular myopathy (XLMTM, OMIM 310400) is a severe congenital muscular disease due to mutations in the myotubularin gene (MTM1) and characterized by the presence of small myofibers with frequent occurrence of central nuclei.
Montus, Marie +16 more
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MTMR4 is required for the stability of the Salmonella-containing vacuole
Frontiers in Cellular and Infection Microbiology, 2016 The intracellular pathogen Salmonella enterica servovar Typhimurium (S. typhimurium) modulates the host cell’s phosphoinositide (PI) metabolism to establish its intracellular replicative niche, the Salmonella-containing vacuole (SCV).
Wei Xuan Teo +2 more
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Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger +18 more
wiley +1 more source
Frontiers in Physiology, 2014 Macropinosome formation requires the sequential activation of numerous signaling pathways that coordinate the actin-driven formation of plasma membrane protrusions (ruffles) and circular ruffles (macropinocytic cups), followed by the closure of these ...
Youhei eEgami +7 more
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