Results 61 to 70 of about 2,993 (188)

PHLPP is neither a Phosphatase nor a Tumor Suppressor

BioEssays, Volume 48, Issue 7, July 2026.
PH domain leucine‐rich repeat protein phosphatases (PHLPP) have been described as Akt phosphatases and tumor suppressors for more than 20 years. Recent evidence, however, indicates that they are pseudophosphatases that lost catalytic activity more than 450 Mya. This article argues that new hypotheses are urgently needed to reorient the field.
Thomas A. Leonard
wiley   +1 more source

Protein-protein interactions between myotubularin and MTMR12 proteins.

, 2013
(A) GST pull down of MTM1-GST recombinant protein with MTMR12 showed a direct interaction between the two proteins (above). Coomassie blue stained gel (below) showing GST and MTM1-GST protein used in the pull down (B) Co-IP experiments from Cos-1 ...
Karim Hnia (127778), Stacey R. Gundry (424531), Laura L. Smith (424530), Ethan A. Talbot (424535), Nathaniel E. Goldman (424536), Vandana A. Gupta (142475), Jocelyn Laporte (127789), Junko Shimazu (424533), Leonela Amoasii (127770), Jessica R. Bass (424534), Alan H. Beggs (142493), Jessica E. McIntire (424532)   +11 more
core   +1 more source

BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes

Circulation Research, 2023
Background: Transverse tubules (t-tubules) form gradually in the developing heart, critically enabling maturation of cardiomyocyte Ca 2+ homeostasis. The membrane bending and scaffolding protein BIN1 (bridging integrator 1) has been implicated in this process.
Perdreau-Dahl, Harmonie, Lipsett, David, Frisk, Michael, Kermani, Fatemeh, Carlson, Cathrine, Brech, Andreas, Shen, Xin, Bergan-Dahl, Anna, Hou, Yufeng, Tuomainen, Tomi, Tavi, Pasi, Jones, Peter, Lunde, Marianne, Wasserstrom, J Andrew, Laporte, Jocelyn, Ullrich, Nina, Christensen, Geir, Morth, J Preben, Louch, William, Wasserstrom, J. Andrew, Morth, J. Preben   +20 more
openaire   +5 more sources

T-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases

Skeletal Muscle, 2011
In skeletal muscle, the excitation-contraction (EC) coupling machinery mediates the translation of the action potential transmitted by the nerve into intracellular calcium release and muscle contraction.
Al-Qusairi Lama, Laporte Jocelyn
doaj   +1 more source

Myotubularin‐Related Protein14 Prevents Neointima Formation and Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo‐Like Kinase1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Restenosis is one of the main bottlenecks in restricting the further development of cardiovascular interventional therapy. New signaling molecules involved in the progress have continuously been discovered; however, the specific molecular ...
Ling‐Yao Kong, Cui Liang, Peng‐Cheng Li, Yi‐Wei Zhang, Sheng‐Dong Feng, Dian‐Hong Zhang, Rui Yao, Lu‐Lu Yang, Zheng‐Yang Hao, Hao Zhang, Xiao‐Xu Tian, Chen‐Ran Guo, Bin‐Bin Du, Jian‐Zeng Dong, Yan‐Zhou Zhang   +14 more
doaj   +1 more source

Silencing of the Charcot–Marie–Tooth associated MTMR2 gene decreases proliferation and enhances cell death in primary cultures of Schwann cells

Neurobiology of Disease, 2007
Loss of function of the myotubularin (MTM)-related protein 2 (MTMR2) in Schwann cells causes Charcot–Marie–Tooth disease type 4B1, a severe demyelinating neuropathy, but the consequences of MTMR2 disruption in Schwann cells are unknown.
Alexandre Chojnowski, Nicole Ravisé, Corinne Bachelin, Christel Depienne, Merle Ruberg, Bernard Brugg, Jocelyn Laporte, Anne Baron-Van Evercooren, Eric LeGuern   +8 more
doaj   +1 more source

Gradients of PI(4,5)P2 and PI(3,5)P2 Jointly Participate in Shaping the Back State of Dictyostelium Cells

Frontiers in Cell and Developmental Biology, 2022
Polarity, which refers to the molecular or structural asymmetry in cells, is essential for diverse cellular functions. Dictyostelium has proven to be a valuable system for dissecting the molecular mechanisms of cell polarity.
Dong Li, Dong Li, Feifei Sun, Feifei Sun, Yihong Yang, Hui Tu, Hui Tu, Huaqing Cai, Huaqing Cai   +8 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway

, 2000
Myotubular myopathy (MTM1) is an X-linked disease, characterized by severe neonatal hypotonia and generalized muscle weakness, with pathological features suggesting an impairment in maturation of muscle fibres.
Payrastre, Bernard, Mandel, Jean-Louis, Blondeau, François, Laporte, Jocelyn, Superti-Furga, Giulio, Bodin, Stephane   +5 more
core   +1 more source

Expression of myotubularin and its mutations in a bacterial system

, 2007
Die X-gebundene Myotubuläre Myopathie (XLMTM) ist eine sehr seltene und schwere angeborene Muskelschwäche, die durch Mutationen im MTM 1 Gen verursacht wird.
Dellinger, Eva
core   +2 more sources