Results 51 to 60 of about 593,619 (307)

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

New creative perspective on existential and social undercurrents in British Gothic novels

Creativity Studies
Changes that occur often in the world around us in accordance with each period’s change. It is a common trend in writing to introduce new tendencies, and the Gothic subgenre exhibits this tendency. The term Gothic has its roots in the early 16th century
Aswathy A. S. Nair, Laxmi Dhar Dwivedi
doaj   +1 more source

Eternal Immolation: could a Trinitarian coordinating-concept for Theistic Metaphysics solve the Problems of Theodicy? [PDF]

, 2017
The author contextualizes the Problem of Evil in Open Theism system, listing its main theses, primarily the logic-of- love-defense (and free-will-defense) connected to Trinitarian speculation.
Migliorini, Damiano
core   +2 more sources

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Control Strategies in Guanine Biocrystallization

Angewandte Chemie, EarlyView.
Biological guanine crystals produce spectacular photonic phenomena in animals and hold great promise as new, sustainable optical materials. We review how organisms precisely control the structure, morphologies, and resulting optical properties of these crystals using a set of ingenious ‘design’ strategies, including control of pH, template‐directed ...
Shashanka S. Indri, Avital Wagner, Benjamin A. Palmer   +2 more
wiley   +2 more sources

Mysterious bruises

Journal of Postgraduate Medicine, 2012
A 69-year-old man presented with multiple spontaneous bruises in the past 2 weeks. Several large-sized hematomas were found on examination. The initial investigation revealed a prolonged activated partial thromboplastin time (aPTT) with normal platelet count and international normalized ratio.
H, Chen, J, Jiao, C P, Cheung, S, Borra
openaire   +2 more sources

A mysterious duality [PDF]

Advances in Theoretical and Mathematical Physics, 2001
We establish a correspondence between toroidal compactifications of M-theory and del Pezzo surfaces. M-theory on T^k corresponds to P^2 blown up at k generic points; Type IIB corresponds to P^1\times P^1. The moduli of compactifications of M-theory on rectangular tori are mapped to Kahler moduli of del Pezzo surfaces.The U-duality group of M-theory ...
Iqbal, Amer, Neitzke, Andrew, Vafa, Cumrun   +2 more
openaire   +2 more sources

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Unveiling the Artificial Neural Network Mystery with Special Reference to Applications in Civil Engineering [PDF]

Computational Engineering and Physical Modeling
Over the past few decades, Artificial Neural Networks (ANN) have carved a niche within the Civil Engineering applications and has been a supplementary to the traditional mathematical models.
Shreenivas Londhe, Preeti Kulkarni, Pradnya Dixit, Shalaka Shah, Shardul Joshi, Pali Sahu Sahu   +5 more
doaj   +1 more source