Results 81 to 90 of about 3,522 (161)

Poxvirus K3 Orthologs Regulate NF-κB-Dependent Inflammatory Responses by Targeting the PKR–eIF2α Axis in Multiple Species

Vaccines
Background: Protein kinase R (PKR) inhibits general mRNA translation by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2).
Huibin Yu, Mary Eloise L. Fernandez, Chen Peng, Dewi Megawati, Greg Brennan, Loubna Tazi, Stefan Rothenburg   +6 more
doaj   +1 more source

Decrease in C-reactive protein levels in rabbits after vaccination with a live attenuated myxoma virus vaccine

Veterinární Medicína, 2016
The aim of this study was to evaluate the acute phase reaction and immune response of rabbits triggered by vaccination with a live attenuated myxoma virus (MXT) vaccine.
L. Ondruska, V. Parkanyi, J. Vasicek, R. Jurcik, E. Hanusova, D. Vasicek, A. Balazi, F. Vizzarri   +7 more
doaj   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Safety of an Oncolytic Myxoma Virus in Dogs with Soft Tissue Sarcoma

Viruses, 2018
Many oncolytic viruses that are efficacious in murine cancer models are ineffective in humans. The outcomes of oncolytic virus treatment in dogs with spontaneous tumors may better predict human cancer response and improve treatment options for dogs with ...
Amy L. MacNeill, Kristen M. Weishaar, Bernard Séguin, Barbara E. Powers   +3 more
doaj   +1 more source

Evolutionary History and Attenuation of Myxoma Virus on Two Continents

PLoS Pathogens, 2012
The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence. However, the evolutionary genetics of this profound change in host-pathogen relationship is unknown.
Kerr, Peter J., Ghedin, Elodie, DePasse, Jay V., Fitch, Adam, Cattadori, Isabella M., Hudson, Peter J., Tscharke, David C., Read, Andrew F., Holmes, Edward C.   +8 more
openaire   +5 more sources

Oclacitinib and Myxoma Virus Therapy in Dogs with High-Grade Soft Tissue Sarcoma. [PDF]

Biomedicines, 2023
Ashton LV, Weishaar KM, Séguin B, MacNeill AL.   +3 more
europepmc   +1 more source

Defects in intratumoral arginine metabolism attenuate the replication and therapeutic efficacy of oncolytic myxoma virus. [PDF]

J Immunother Cancer, 2023
Dryja P, Curtsinger HD, Bartee MY, Bartee E.   +3 more
europepmc   +1 more source

Nuclear Export Inhibitor Selinexor Enhances Oncolytic Myxoma Virus Therapy against Cancer. [PDF]

Cancer Res Commun, 2023
Rahman MM, van Oosterom F, Enow JA, Hossain M, Gutierrez-Jensen AD, Cashen M, Everts A, Lowe K, Kilbourne J, Daggett-Vondras J, Karr TL, McFadden G.   +11 more
europepmc   +1 more source

Virulence evolution of a salmonid virus following a host jump.

PLoS Pathogens
Emergent viral diseases remain a critical obstacle to welfare across landscapes and species, encompassing humans, wildlife, and agriculture. Following a jump to a novel host, the severity of disease resulting from infection is a critical determinant of ...
Malina M Loeher, Gael Kurath, David A Kennedy, Joanne E Salzer, William N Batts, Rachel B Breyta, Andrew R Wargo   +6 more
doaj   +1 more source

Oncolytic myxoma virus is effective in murine models of triple negative breast cancer despite poor rates of infection. [PDF]

Mol Ther Oncolytics, 2023
Thomas RJ, Bartee MY, Valenzuela-Cardenas M, Bartee E.   +3 more
europepmc   +1 more source