Results 101 to 110 of about 4,101 (195)

Evolutionary History and Attenuation of Myxoma Virus on Two Continents

PLoS Pathogens, 2012
The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence. However, the evolutionary genetics of this profound change in host-pathogen relationship is unknown.
Kerr, Peter J., Ghedin, Elodie, DePasse, Jay V., Fitch, Adam, Cattadori, Isabella M., Hudson, Peter J., Tscharke, David C., Read, Andrew F., Holmes, Edward C.   +8 more
openaire   +5 more sources

Endosomal/Lysosomal Retention and Degradation of Major Histocompatibility Complex Class I Molecules Is Induced by Myxoma Virus

, 1999
The highly immunosuppressive leporipoxvirus myxoma, previously was shown to promote the loss of cell surface class I major histocompatibility complex (MHC I) molecules.
Wang, Hong, McFadden, Grant, Barry, Michele, Zúñiga, Martha C.   +3 more
core   +1 more source

Calicivirus, myxoma virus and the wild rabbit in Australia : a tale of three invasions

, 2001
The history, ecology and genetics of the European rabbit and the two viruses, myxoma virus and calicivirus, used to control the rabbit in Australia offer a useful set of parallels and insights into the behaviour of such systems.
Richardson, Barry J.
core  

Multiple cross-spectral function of myxoma virus proteins (10 sequences alignment).

, 2013
Multiple cross-spectral function of myxoma virus proteins (10 sequences alignment).
Elena Pirogova (80011), Peter J. Coloe (343918), Irena Cosic (80010), Emily Gan (343916), Taghrid S. Istivan (343915), Nahlah M. Almansour (343917)   +5 more
core   +1 more source

Poxvirus K3 Orthologs Regulate NF-κB-Dependent Inflammatory Responses by Targeting the PKR–eIF2α Axis in Multiple Species

Vaccines
Background: Protein kinase R (PKR) inhibits general mRNA translation by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2).
Huibin Yu, Mary Eloise L. Fernandez, Chen Peng, Dewi Megawati, Greg Brennan, Loubna Tazi, Stefan Rothenburg   +6 more
doaj   +1 more source

Decrease in C-reactive protein levels in rabbits after vaccination with a live attenuated myxoma virus vaccine

Veterinární Medicína, 2016
The aim of this study was to evaluate the acute phase reaction and immune response of rabbits triggered by vaccination with a live attenuated myxoma virus (MXT) vaccine.
L. Ondruska, V. Parkanyi, J. Vasicek, R. Jurcik, E. Hanusova, D. Vasicek, A. Balazi, F. Vizzarri   +7 more
doaj   +1 more source

Sequence mapping of the Californian MSW strain of Myxoma virus

Archives of Virology, 2003
Partial sequence mapping of the MSW Californian strain of Myxoma virus was performed by cloning EcoRI and SalI restriction fragments of viral DNA and sequencing the ends of these. In this way, regions of 74 MSW open reading frames were sequenced and mapped onto the complete genome sequences of the related leporipoxviruses South American Myxoma virus ...
Labudovic, Andelka, Perkins, Harvey, van Leeuwen, Barbara, Kerr, Peter   +3 more
openaire   +3 more sources

Evolutionary clash between myxoma virus and rabbit PKR in Australia

, 2016
The success of a virus in defeating or evading cell-intrinsic immune responses contributes to its virulence, pathogenesis, and host range. A central tenet of virology holds that virus and host coevolve as each adapts to survive.
Burgess, Hannah M, Mohr, Ian
core   +1 more source

Safety of an Oncolytic Myxoma Virus in Dogs with Soft Tissue Sarcoma

Viruses, 2018
Many oncolytic viruses that are efficacious in murine cancer models are ineffective in humans. The outcomes of oncolytic virus treatment in dogs with spontaneous tumors may better predict human cancer response and improve treatment options for dogs with ...
Amy L. MacNeill, Kristen M. Weishaar, Bernard Séguin, Barbara E. Powers   +3 more
doaj   +1 more source

Stress Beyond Translation: Poxviruses and More

Viruses, 2016
Poxviruses are large double-stranded DNA viruses that form viral factories in the cytoplasm of host cells. These viruses encode their own transcription machinery, but rely on host translation for protein synthesis. Thus, poxviruses have to cope with and,
Jason Liem, Jia Liu
doaj   +1 more source