Results 121 to 130 of about 2,418 (169)

Hydroxylation and N-demethylation of N,N-dimethyltryptamine

Experientia, 1959
Der intermediare Stoffwechsel des psychotropen N,N-Dimethyltryptamins wurde untersucht. N-Methyltryptamin, als Produkt der Demethylierung, und 6-Hydroxy-N,N-Dimethyltryptamin, als Produkt der Hydroxylierung, wurden nachgewiesen und papierchromatographisch charakterisiert.
S, SZARA, J, AXELROD
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[Elimination of N,N-dimethyltryptamine by urine].

Acta psiquiatrica y psicologica de America latina, 1994
N,N-dimethiltryptamine (DMT) in urine has been quantified on an 83-psychiatric patient sample. Sample covered patients who had sometimes been administered neuroleptic drugs as well as patients with some particular symptomatology associated to psychotic disorders such as hallucinations, delusions, perception disorders, etc. 43.3% (36 cases) evidenced an
N, Spatz, H, Spatz, H L, Mesones Arroyo, T, Rosan, F, Brengio   +4 more
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Human psychopharmacology of N,N-dimethyltryptamine

Behavioural Brain Research, 1995
We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures. Subjective responses were quantified with a new rating scale, the HRS, which provided better resolution of dose effects ...
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Studies on several 7-substituted N,N-dimethyltryptamines

Journal of Medicinal Chemistry, 1980
Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me- and 5-OMe-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself.
R A, Glennon, E, Schubert, J M, Jacyno, J A, Rosecrans   +3 more
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PHARMACOKINETICS OF N,N-DIMETHYLTRYPTAMINE FUMARATE IN HUMANS

2022
Aim: N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the in vitro metabolism and clinical pharmacokinetics (PK) of DMT fumarate (SPL026) in healthy subjects.
Meghan Good, Tiffanie Benway, Zelah Joel, Carol Routledge, Christopher Timmermann, David Erritzoe, Richard Weaver, Graham Allen, Charlotte Hughes, Helen Topping, Amy Bowan (Pharmaron UK), Ellen James   +11 more
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The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine

American Journal of Psychiatry, 1976
The authors review the research on N,N-dimethyltryptamine (DMT) as a possible "schizotoxin." DMT produces psychedelic effects when administered to normal subjects, the means are present to synthesize it in man, it has occasionally been found in man, and tolerance to its behavioral effects is incomplete.
J C, Gillin, J, Kaplan, R, Stillman, R J, Wyatt   +3 more
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N,N-dimethyltryptamine like substance in rat brain

Life Sciences, 1973
Abstract Rat brain contains 8 μg/g of a tertiary amine, very probably N,N-dimethyltryptamine as shown by bidimensional thin layer and gas ohromatography. Pretreatment with Nialamide did not modify the concentration of this substance in the brain.
B, Heller, E, Fischer, H, Spats
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Persistent Tinnitus after Inhaled N,N-dimethyltryptamine (DMT)

Journal of Psychoactive Drugs, 2020
This case report describes a 39-year-old male with remote history of polysubstance use disorder and depression who developed tinnitus after use of inhaled N,N-dimethyltryptamine (DMT). Although development of ear ringing was attributed to use on a single occasion, tinnitus occurred within the context of a larger self-experiment involving weekly ...
Heba Diab, Benjamin Malcolm
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Increased synthesis of striatal dopamine by N,N-dimethyltryptamine

Life Sciences, 1977
Abstract The effect of acute doses of N,N-dimethyltryptamine (DMT) on the synthesis or degradation rates of rat diencephalon norepinephrine and striatal dopamine was estimated by administering 150 μCi L-tyrosine-3,5- 3 H at various times before sacrifice. In all cases DMT, 20 mg/kg, was injected one-half hour before sacrifice.
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Effects of N, N-dimethyltryptamine on intracranial self-stimulation in the rat

Life Sciences, 1973
Abstract Three rats were injected ip with a series of doses of N, N-dimethyltryptamine and tested in a self stimulation paradigm. Results indicated that higher doses of DMT (2.0 mg/kg and above) produced marked decrements in responding with lower doses having little or no effect.
A J, Rosen, K L, Kubos
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