Results 111 to 120 of about 2,418 (169)
Behavioral effects of N,N-dimethyltryptamine in rats and mice.
Revista brasileira de biologia, 1972 H, Moussatché +2 more
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Phytochemistry, 1972
Abstract The biosynthesis and turnover of N , N -dimethyltryptamine and 5-methoxy- N , N -dimethyltryptamine have been studied in the pasture grass Phalaris tuberosa by a combination of feeding and trapping experiments using radioisotopically labelled compounds. Their turnover has been demonstrated by feeding tryptophan and tryptamine.
M Slaytor
exaly +2 more sources
Abstract The biosynthesis and turnover of N , N -dimethyltryptamine and 5-methoxy- N , N -dimethyltryptamine have been studied in the pasture grass Phalaris tuberosa by a combination of feeding and trapping experiments using radioisotopically labelled compounds. Their turnover has been demonstrated by feeding tryptophan and tryptamine.
M Slaytor
exaly +2 more sources
Pharmacology Biochemistry and Behavior, 1978
Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses.
Michael H Sheard
exaly +3 more sources
Rats were tested for shock elicited fighting under various doses of N,N-dimethyltryptamine (0.12, 0.25, 0.50, 1.0, 4.0, 8.0 mg/kg) and 5-methoxy-N,N-dimethyltryptamine (0.06, 0.12, 0.5, 2.0 mg/kg). Both drugs produced an inhibition of fighting at higher doses but no significant effects at lower doses.
Michael H Sheard
exaly +3 more sources
A comparison of the behavioral effects of proteo- and deutero-N, N-dimethyltryptamine
Pharmacology Biochemistry and Behavior, 1982The behavioral effects of N,N-dimethyltryptamine (DMT) and α, α, β, β-tetradeutero-N,N-dimethyltryptamine (D4DMT) at dose levels of 2.5 and 5.0 mg/kg were examined in rats on a food reinforced schedule. The D4DMT was observed to produce a significantly greater disruption of behavior, have a longer duration of action and a shorter time to onset than DMT.
Steven A Barker, Wu-Fu Liu, W F Liu
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Metabolic Engineering, 2023
N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) are psychedelic tryptamines found naturally in both plants and animals and have shown clinical potential to help treat mental disorders, such as anxiety and depression.
Lucas M. Friedberg +6 more
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N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) are psychedelic tryptamines found naturally in both plants and animals and have shown clinical potential to help treat mental disorders, such as anxiety and depression.
Lucas M. Friedberg +6 more
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In vivo metabolism of 5-methoxy-N, N-dimethyltryptamine and N,N-dimethyltryptamine in the rat
Biochemical Pharmacology, 1987Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N ...
B R, Sitaram +4 more
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N,N-Dimethyltryptamine–Induced Psychosis
Clinical Neuropharmacology, 2015N,N-dimethyltryptamine (DMT) is a 5-hydroxytryptamine 2A and 1A receptor agonist that exhibits potent psychoactive properties in humans. Recreational use of this drug has increased precipitously and is likely to result in an increase in patients presenting with substance-induced psychoses. The present case provides an early example of substance-induced
Neil E, Paterson +2 more
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N,N-Dimethyltryptamine: An Endogenous Hallucinogen
1981Publisher Summary This chapter reviews the biosynthesis, metabolism, pharmacology, and properties of N,N-dimethyltryptamine (DMT), leading to a conclusion that DMT may be a neurotransmitter in the mammalian brain. The identification of DMT and other hallucinogens in man explains the experience of hallucinatory phenomena in general.
S A, Barker, J A, Monti, S T, Christian
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Neuromodulatory mechanisms of N,N-dimethyltryptamine
Brain Network and Modulation, 2023N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated ...
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A new metabolic pathway for N,N-dimethyltryptamine
Biological Psychiatry, 1986N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is present in extracts of these treated tissues. The compound responsible for this peak has been identified by ultraviolet spectrophotometry and by mass spectrometry ...
L M, Hryhorczuk +3 more
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