Results 11 to 20 of about 1,029,181 (225)

Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis. [PDF]

Clin Pharmacokinet
N,N-Dimethyltryptamine (DMT) is currently being studied for its therapeutic potential in various psychiatric disorders. An understanding of its pharmacokinetics (PK) is essential to determine appropriate dose ranges in future clinical studies.
van der Heijden KV, Otto ME, Schoones JW, van Esdonk MJ, Borghans LGJM, van Hasselt JGC, van Gerven JMA, Jacobs G.   +7 more
europepmc   +2 more sources

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences. [PDF]

Neuropsychopharmacology
Exploring the intricate relationship between brain’s structure and function, and how this affects subjective experience is a fundamental pursuit in neuroscience.
Vohryzek J, Luppi AI, Atasoy S, Deco G, Carhart-Harris RL, Timmermann C, Kringelbach ML.   +6 more
europepmc   +2 more sources

Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine. [PDF]

Front Pharmacol, 2023
Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affective and other ...
Dornbierer DA, Marten L, Mueller J, Aicher HD, Mueller MJ, Boxler M, Kometer M, Kosanic D, von Rotz R, Puchkov M, Kraemer T, Landolt HP, Seifritz E, Scheidegger M.   +13 more
europepmc   +2 more sources

The clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). [PDF]

J Neurochem, 2022
5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) is a naturally occurring tryptamine that primarily acts as an agonist at the 5‐HT1A and 5‐HT2A receptors, whereby affinity for the 5‐HT1A subtype is highest.
Reckweg JT, Uthaug MV, Szabo A, Davis AK, Lancelotta R, Mason NL, Ramaekers JG.   +6 more
europepmc   +2 more sources

N,N‐dimethyltryptamine affects electroencephalography response in a concentration‐dependent manner—A pharmacokinetic/pharmacodynamic analysis [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2023
N,N‐dimethyltryptamine (DMT) is a psychedelic substance and is being used as a research tool in investigations of the neurobiology behind the human consciousness using different brain imaging techniques.
Emma Eckernäs, Christopher Timmermann, Robin Carhart‐Harris, Daniel Röshammar, Michael Ashton   +4 more
doaj   +2 more sources

Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors. [PDF]

Cell Mol Life Sci
The potent hallucinogen N,N-dimethyltryptamine (DMT) has garnered significant interest in recent years due to its profound effects on consciousness and its therapeutic psychopotential.
Egger K, Aicher HD, Cumming P, Scheidegger M.   +3 more
europepmc   +2 more sources

Electrogenerated Chemiluminescence Coupled with Molecularly Imprinted Polymer for Sensitive and Selective Detection of <i>N</i>,<i>N</i>-Dimethyltryptamine. [PDF]

Anal Chem
A simple and efficient approach that combined electrogenerated chemiluminescence (ECL) and molecularly imprinted polymers (MIPs) for selective and sensitive detection of the hallucinogenic drug N,N-dimethyltryptamine (DMT) was developed.
Motchaalangaram JA, Mahalingam P, Wallace KJ, Miao W.   +3 more
europepmc   +2 more sources

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT. [PDF]

Psychopharmacology (Berl), 2022
As with all drugs, the route, form, and/or dose of a substance administered or applied can play a defining role in its overall pharmacology and use as a therapeutic.
Barker SA.
europepmc   +2 more sources

A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression. [PDF]

Front Psychiatry, 2023
Background Treatment-resistant depression (TRD) is a substantial public health burden, but current treatments have limited effectiveness. The aim was to investigate the safety and potential antidepressant effects of the serotonergic psychedelic drug 5 ...
Reckweg JT, van Leeuwen CJ, Henquet C, van Amelsvoort T, Theunissen EL, Mason NL, Paci R, Terwey TH, Ramaekers JG.   +8 more
europepmc   +2 more sources

Psychedelics and immunomodulation: Novel approaches and therapeutic opportunities [PDF]

Frontiers in Immunology, 2015
Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant modulatory effects on immune responses by altering signaling pathways involved in inflammation, cellular ...
Attila eSzabo
doaj   +6 more sources