, 2020 A mystery that has been going on for centuries. The N,N-dimethyltryptamine (DMT) molecule, which is found in every living thing, especially in humans at the time of birth and death, and which some claim to open the door of the parallel universes, is a ...
YÜCEL, Kamile
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Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. [PDF]
PLoS ONE, 2014 The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory ...
Attila Szabo +3 more
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Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT) [PDF]
Frontiers in PharmacologyThe modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy of psychedelics in disorders involving socio-emotional and reward processing deficits.
Carla Soares +10 more
doaj +2 more sources
N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk [PDF]
Alzheimer’s Research & TherapyBackground Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD).
Dan Cheng +5 more
doaj +3 more sources
Pharmacokinetics of N,N-dimethyltryptamine in Humans. [PDF]
Eur J Drug Metab Pharmacokinet, 2023 N,N-dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the preclinical and clinical pharmacokinetics and metabolism of DMT in healthy subjects.The physiochemical properties of DMT were determined using a series of in vitro experiments and its metabolic profile ...
Good M +11 more
europepmc +3 more sources
Short-term safety and tolerability profile of 5-methoxy-N,N-dimethyltryptamine in human subjects: a systematic review of clinical trials [PDF]
Frontiers in PsychiatryIntroductionPsychedelic agents have regained the attention of pharmaceutical companies as promising treatments for depressive episodes. 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), an atypical psychedelic, is emerging as a potentially effective, novel ...
Aleksander Kwaśny +2 more
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N,N-dimethyltryptamine and Amazonian ayahuasca plant medicine. [PDF]
Hum Psychopharmacol, 2022 AbstractObjectiveReports have indicated possible uses of ayahuasca for the treatment of conditions including depression, addictions, post‐traumatic stress disorder, anxiety and specific psychoneuroendocrine immune system pathologies. The article assesses potential ayahuasca and N,N‐dimethyltryptamine (DMT) integration with contemporary healthcare.
James E +3 more
europepmc +5 more sources
Extraction and Characterization of N,N‑Dimethyltryptamine from Mimosa tenuiflora: A Multivariate Approach [PDF]
ACS OmegaLucas Cordeiro de Oliveira +10 more
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Neuropharmacology of N,N-dimethyltryptamine [PDF]
Brain Research Bulletin, 2016 N,N-dimethyltryptamine (DMT) is an indole alkaloid widely found in plants and animals. It is best known for producing brief and intense psychedelic effects when ingested. Increasing evidence suggests that endogenous DMT plays important roles for a number of processes in the periphery and central nervous system, and may act as a neurotransmitter.
Theresa M, Carbonaro, Michael B, Gatch
openaire +2 more sources
Parapsychology, N, N-Dimethyltryptamine and the Pineal Gland
, 2019 In the last decades, one of the psychedelic substances which has gained high attention for its implications in several para-psychological phenomena (including out-of-body states, deep changes in sensory perception, mood, and thought, travels in ...
Bragazzi, Nicola Luigi +8 more
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