Results 21 to 30 of about 2,418 (169)

Concise Synthesis of -Dimethyltryptamine and 5-Methoxy--dimethyltryptamine Starting with Bufotenine from Brazilian ssp

Natural Product Communications, 2015
Bufotenine ( 1 , 5-hydroxy- N,N -dimethyltryptamine) was isolated from seeds of Anadenanthera spp., a tree widespread in the Brazilian cerrado, using an efficient acid-base shakeout protocol. The conversion of bufotenine into N,N -dimethyltryptamine ( 4 )
Leandro A. Moreira, Maria M. Murta, Claudia C. Gatto, Christopher W. Fagg, Maria L. dos Santos   +4 more
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Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells.

PLoS ONE, 2014
The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory ...
Attila Szabo, Attila Kovacs, Ede Frecska, Eva Rajnavolgyi   +3 more
doaj   +1 more source

Indolethylamine-N-methyltransferase Polymorphisms: Genetic and Biochemical Approaches for Study of Endogenous N,N,-dimethyltryptamine

Frontiers in Neuroscience, 2018
N,N-dimethyltryptamine (DMT) is a powerful serotonergic psychedelic whose exogenous administration elicits striking psychedelic effects in humans. Studies have identified DMT and analogous compounds (e.g., 5-hydroxy-DMT, 5-methoxy-DMT) alongside of an ...
Jon G. Dean
doaj   +1 more source

In Vitro Study of the Bioavailability and Bioaccessibility of the Main Compounds Present in Ayahuasca Beverages

Molecules, 2021
Ayahuasca is a psychoactive beverage that contains the psychoactive compound N,N-dimethyltryptamine and β-carboline alkaloids. This study aims at determining in vitro the bioavailability and bioaccessibility of the main compounds present in decoctions of
Joana Gonçalves, Miguel Castilho, Tiago Rosado, Ângelo Luís, José Restolho, Nicolás Fernández, Eugenia Gallardo, Ana Paula Duarte   +7 more
doaj   +1 more source

A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N, N-Dimethyltryptamine (DMT) use: a case report [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2011
, N-dimethyltryptamine (DMT) is a serotonin agonist hallucinogen, similar to lysergic acid diethylamide (LSD). Syntetic production of DMT as well as extraction from several plants of South American flora is possible.
Güliz Özgen, İlker Küçükparlak, Gökhan Umut, Ahmet Türkcan   +3 more
doaj  

A Review of Aeruginascin and Potential Entourage Effect in Hallucinogenic Mushrooms

European Psychiatry, 2022
Introduction The 5-HT2A agonist classic psychedelic, psilocybin (O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine) is a tryptophan, indole-based alkaloid present in up to 2% of certain hallucinogenic “magic” mushroom species; typically Psilocybe azurescens,
P. Chue, A. Andreiev, E. Bucuci, C. Els, J. Chue   +4 more
doaj   +1 more source

Potential therapeutic use of ayahuasca: A literature review [PDF]

Acta Amazonica
Ayahuasca is a psychoactive decoction originally used in indigenous Amazonian culture. It consists of a dense brown liquid that most frequently results from the decoction of two plants native to the Amazon rainforest, Psychotria viridis (Rubiaceae) and ...
Salvana Priscylla Manso COSTA, Keith Cardoso CARVALHO, Isabella Nunes GOMES, Carine Lopes CALAZANS, Morganna Thinesca Almeida SILVA, Joseneide de Alves MIRANDA, Ighor Costa BARRETO, Matheus Vinícius Guimarães de MELO, Keyla Emanuelle Ramos de HOLANDA, José Marcos Teixeira de ALENCAR FILHO   +9 more
doaj   +1 more source

Ayahuasca and Its DMT- and β-carbolines – Containing Ingredients Block the Expression of Ethanol-Induced Conditioned Place Preference in Mice: Role of the Treatment Environment

Frontiers in Pharmacology, 2018
Ayahuasca is a hallucinogenic beverage produced from the decoction of Banisteriopsis caapi (Bc) and Psychotria viridis (Pv), β-carboline- and N,N-dimethyltryptamine(DMT)-containing plants, respectively.
Elisangela G. Cata-Preta, Yasmim A. Serra, Eliseu da C. Moreira-Junior, Henrique S. Reis, Natali D. Kisaki, Matheus Libarino-Santos, Raiany R. R. Silva, Thaísa Barros-Santos, Lucas C. Santos, Paulo C. R. Barbosa, José L. Costa, Alexandre J. Oliveira-Lima, Lais F. Berro, Eduardo A. V. Marinho   +13 more
doaj   +1 more source

Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space

Marine Drugs, 2017
In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads.
Mohamed A. Ibrahim, Abir T. El-Alfy, Kelly Ezel, Mohamed O. Radwan, Abbas G. Shilabin, Anna J. Kochanowska-Karamyan, Howaida I. Abd-Alla, Masami Otsuka, Mark T. Hamann   +8 more
doaj   +1 more source

DMT Models the Near-Death Experience

Frontiers in Psychology, 2018
Near-death experiences (NDEs) are complex subjective experiences, which have been previously associated with the psychedelic experience and more specifically with the experience induced by the potent serotonergic, N,N-Dimethyltryptamine (DMT).
Christopher Timmermann, Christopher Timmermann, Leor Roseman, Leor Roseman, Luke Williams, David Erritzoe, Charlotte Martial, Héléna Cassol, Steven Laureys, David Nutt, Robin Carhart-Harris   +10 more
doaj   +1 more source