Results 21 to 30 of about 10,565,775 (206)

Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings: An initial exploratory analysis of the phenomenon’s predictors and its emotional valence [PDF]

Frontiers in Psychiatry, 2022
BackgroundThe psychedelic 5-MeO-DMT has shown clinical potential due to its short duration and ability to induce mystical experiences. However, a phenomenon known as “reactivations” (similar to “flashbacks”) is a poorly understood and frequently reported
Ana María Ortiz Bernal, Charles L. Raison, Rafael L. Lancelotta, Alan K. Davis, Alan K. Davis   +4 more
doaj   +2 more sources

Safety, Pharmacokinetics, and Pharmacodynamics of a 6‐h N,N‐Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Trial [PDF]

Clinical and Translational Science
The serotonergic psychedelic N,N‐dimethyltryptamine (DMT) presumably stimulates neuroplasticity in vitro and in vivo, by which it may exert neuroprotective effects during acute ischemic stroke.
Katelijne V. van derHeijden, Rob G. J. A. Zuiker, Marije E. Otto, Christopher S. Bryan, Nancy Stewart, Christopher Stillwell, Marieke L. De Kam, Marloes B. vanLeuken, Joop M. A. vanGerven, Gabriel E. Jacobs   +9 more
doaj   +2 more sources

Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. [PDF]

PLoS ONE, 2014
The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory ...
Attila Szabo, Attila Kovacs, Ede Frecska, Eva Rajnavolgyi   +3 more
doaj   +2 more sources

Investigating the Synergistic Neuroprotective Effects of Plant-Derived Antioxidants and the Psychedelic N,N-Dimethyltryptamine in Alzheimer’s Disease Therapy [PDF]

Cells
Alzheimer’s disease (AD) is a chronic and complex neurodegenerative disorder characterized by progressive cognitive decline, memory loss, and irreversible impairment of brain functions.
Júlia Jarne-Ferrer, Mercè Pallàs, Christian Griñán-Ferré, Aina Bellver-Sanchis   +3 more
doaj   +2 more sources

Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis. [PDF]

Clin Pharmacokinet
N,N-Dimethyltryptamine (DMT) is currently being studied for its therapeutic potential in various psychiatric disorders. An understanding of its pharmacokinetics (PK) is essential to determine appropriate dose ranges in future clinical studies. We conducted a systematic literature review on the PK of DMT.Clinical studies that administered known amounts ...
van der Heijden KV, Otto ME, Schoones JW, van Esdonk MJ, Borghans LGJM, van Hasselt JGC, van Gerven JMA, Jacobs G.   +7 more
europepmc   +5 more sources

Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT) [PDF]

Frontiers in Pharmacology
The modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy of psychedelics in disorders involving socio-emotional and reward processing deficits.
Carla Soares, Carla Soares, Gisela Lima, Gisela Lima, Marta Lapo Pais, Marta Teixeira, Célia Cabral, Célia Cabral, Célia Cabral, Miguel Castelo-Branco, Miguel Castelo-Branco   +10 more
doaj   +2 more sources

N,N-Dimethyltryptamine [PDF]

, 2020
A mystery that has been going on for centuries. The N,N-dimethyltryptamine (DMT) molecule, which is found in every living thing, especially in humans at the time of birth and death, and which some claim to open the door of the parallel universes, is a very harmful hallucinogen for some.
openaire   +2 more sources

N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk [PDF]

Alzheimer’s Research & Therapy
Background Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD).
Dan Cheng, Zhuo-Gui Lei, Kin Chu, Oi Jin Honey Lam, Chun Yuan Chiang, Zhang-Jin Zhang   +5 more
doaj   +3 more sources

Short-term safety and tolerability profile of 5-methoxy-N,N-dimethyltryptamine in human subjects: a systematic review of clinical trials [PDF]

Frontiers in Psychiatry
IntroductionPsychedelic agents have regained the attention of pharmaceutical companies as promising treatments for depressive episodes. 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), an atypical psychedelic, is emerging as a potentially effective, novel ...
Aleksander Kwaśny, Alina Wilkowska, Wiesław Jerzy Cubała   +2 more
doaj   +2 more sources

Extraction and Characterization of N,N‑Dimethyltryptamine from Mimosa tenuiflora: A Multivariate Approach [PDF]

ACS Omega
Lucas Cordeiro de Oliveira, Taynah Pereira Galdino, Marcelo da Silva Pedro, Mateus Araujo Luz, Igor de Melo Castro, Evilasio Anisio Costa Filho, João Davi da Silva Gonçalves, Antonio Gilson B. Lima, Victor Ignacio Afonso, Marcus Vinicius Lia Fook, Suédina Maria de Lima Silva   +10 more
doaj   +2 more sources