Results 21 to 30 of about 13,560,164 (207)

Discovery and In Vitro Characterization of SPL028: Deuterated N,N-Dimethyltryptamine. [PDF]

ACS Med Chem Lett, 2023
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. However, when administered via intravenous infusion, its effects are short-lived due to rapid clearance.
Layzell M, Rands P, Good M, Joel Z, Cousins R, Benway T, James E, Routledge C.   +7 more
europepmc   +3 more sources

Infoveillance and Critical Analysis of the Systematically Reviewed Literature on Dimethyltryptamine and the “God Molecule”

Pharmaceuticals, 2023
Aboriginals of Latin America have used DMT (N,N-dimethyltryptamine) in ritualistic ceremonies for centuries. Nevertheless, there are limited data on web users’ interest concerning DMT.
Ahmed Al-Imam, Marek A. Motyka, Beata Hoffmann, Anita Magowska, Michal Michalak   +4 more
doaj   +1 more source

Synthesis and Biological Evaluation of 4‑Bromo-N,N-dimethyltryptamine (4-Br-DMT): A Synthetic Building Block for Future Analog Development [PDF]

ACS Omega
Elena Bray, Grant C. Glatfelter, Alexander D. Maitland, Nicholas R. Gonzalez, Donna Walther, Jeanine Yacoub, Michael H. Baumann, Jacqueline L. von Salm   +7 more
doaj   +2 more sources

N\A [PDF]

N\AThis paper explores the integration of Unmanned Aerial Systems (UAS) for 3D terrain mapping and autonomous navigation, emphasizing the fusion of advanced technologies such as multi-camera setups and reinforcement learning (RL).
Baston, George
core   +3 more sources

Concise Synthesis of -Dimethyltryptamine and 5-Methoxy--dimethyltryptamine Starting with Bufotenine from Brazilian ssp

Natural Product Communications, 2015
Bufotenine ( 1 , 5-hydroxy- N,N -dimethyltryptamine) was isolated from seeds of Anadenanthera spp., a tree widespread in the Brazilian cerrado, using an efficient acid-base shakeout protocol. The conversion of bufotenine into N,N -dimethyltryptamine ( 4 )
Leandro A. Moreira, Maria M. Murta, Claudia C. Gatto, Christopher W. Fagg, Maria L. dos Santos   +4 more
doaj   +1 more source

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

Frontiers in Neuroscience, 2018
This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brain and peripheral tissues, methods and results for DMT ...
Steven A. Barker
doaj   +1 more source

Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis. [PDF]

Clin Pharmacokinet
N,N-Dimethyltryptamine (DMT) is currently being studied for its therapeutic potential in various psychiatric disorders. An understanding of its pharmacokinetics (PK) is essential to determine appropriate dose ranges in future clinical studies. We conducted a systematic literature review on the PK of DMT.Clinical studies that administered known amounts ...
van der Heijden KV, Otto ME, Schoones JW, van Esdonk MJ, Borghans LGJM, van Hasselt JGC, van Gerven JMA, Jacobs G.   +7 more
europepmc   +5 more sources

N-SDM/N-SDM: N-SDM v1.0.0

, 2022
First N-SDM ...
AnAdde, N-SDM
core   +1 more source

Indolethylamine-N-methyltransferase Polymorphisms: Genetic and Biochemical Approaches for Study of Endogenous N,N,-dimethyltryptamine

Frontiers in Neuroscience, 2018
N,N-dimethyltryptamine (DMT) is a powerful serotonergic psychedelic whose exogenous administration elicits striking psychedelic effects in humans. Studies have identified DMT and analogous compounds (e.g., 5-hydroxy-DMT, 5-methoxy-DMT) alongside of an ...
Jon G. Dean
doaj   +1 more source

In Vitro Study of the Bioavailability and Bioaccessibility of the Main Compounds Present in Ayahuasca Beverages

Molecules, 2021
Ayahuasca is a psychoactive beverage that contains the psychoactive compound N,N-dimethyltryptamine and β-carboline alkaloids. This study aims at determining in vitro the bioavailability and bioaccessibility of the main compounds present in decoctions of
Joana Gonçalves, Miguel Castilho, Tiago Rosado, Ângelo Luís, José Restolho, Nicolás Fernández, Eugenia Gallardo, Ana Paula Duarte   +7 more
doaj   +1 more source