Results 51 to 60 of about 269,935 (266)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

N,N-Dibutylanilinium hydrogen squarate

IUCrData, 2017
The title molecular salt, C14H24N+·C4HO4− [systematic name: N,N-dibutylbenzenaminium 2-hydroxy-3,4-dioxocyclobut-1-en-1-olate], is composed of a protonated N,N-dibutylaniline cation with a hydrogen squarate monoanion (common names).
Daron E. Janzen, Rita S. Majerle, Katie L. Novosad   +2 more
doaj   +1 more source

Pyridinium-2-carboxyl­ate–benzene-1,2-diol (1/1) [PDF]

, 2009
The title compound, C6H5NO2·C6H6O2, crystallizes with one pyridinium-2-carboxyl­ate zwitterion and one mol­ecule of benzene-1,2-diol in the asymmetric unit.
Bolte, Michael, Michael Bolte, Cuong, Ton Quoc, Cuong Quoc Ton   +3 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

4-Amino-2-hydroxybenzohydrazide

Acta Crystallographica Section E, 2012
The asymmetric unit of the title compound, C7H9N3O2, comprises two crystallographically independent molecules (A and B). In each molecule there is an intramolecular O—H...O hydrogen bond making an S(6) ring motif.
Hadi Kargar, Reza Kia, Muhammad Nawaz Tahir   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Pyrimidin-2-amine–1-phenylcyclopentane-1-carboxylic acid (1/1)

Acta Crystallographica Section E, 2011
In the crystal structure of the title co-crystal, C4H5N3·C12H14O2, the components are linked by N—H...O and O—H...N hydrogen bonds.
Guangwen He, Srinivasulu Aitipamula, Pui Shan Chow, Reginald B. H. Tan   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Hydrogen-bonding patterns in the cocrystal 2-amino-4,6-dimethoxypyrimidine–anthranilic acid (1/1)

Acta Crystallographica Section E, 2008
In the title cocrystal, C6H9N3O2·C7H7NO2, the asymmetric unit contains two crystallographically independent 2-amino-4,6-dimethoxy pyrimidine-anthranilic acid adducts.
Kaliyaperumal Thanigaimani, Packianathan Thomas Muthiah, Daniel E. Lynch   +2 more
doaj   +1 more source

2-Aminobenzimidazolium O-ethyl malonate: eight independent N-H...O hydrogen bonds generate sheets [PDF]

, 2003
The title compound, C7H8N3+.C5H7O4-, crystallizes with Z' = 2 in space group P2(1)/c; eight independent N - H...O hydrogen bonds [H...O = 1.75 - 1.88 Angstrom, N...O = 2.699 (2) - 2.829 (2) Angstrom and N - H...O = 147 - 179degrees] link the four ...
Insuasty, B, Abonia, R, Low, JN, Cobo, J, Glidewell, Christopher   +4 more
core   +1 more source