Results 71 to 80 of about 559,078 (257)

Crystal structure of 1-(2,4-dimethylphenyl)urea

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title urea derivative, C9H12N2O, the dihedral angle between the benzene ring and the mean plane of the urea group, N—C(=O)—N, is 86.6 (1)°. In the crystal, the urea O atom is involved in three N—H...O hydrogen bonds. Molecules are linked via pairs
L. Jayalakshmi, C. Ramalingan, B. Sridhar, S. Selvanayagam   +3 more
doaj   +1 more source

Hydrogen bonding in two solid phases of phenazine-chloranilic acid (1/1) determined at 170 and 93 K [PDF]

, 2007
The crystal structures in two solid phases, i.e. phase II stable between 146 and 253 K and phase IV below 136 K, of the title compound [phenazine-chloranilic acid (1/1), C12H8N2 center dot C6H2Cl2O4, in phase II, and phenazinium hydrogen chloranilate ...
Asaji, Tetsuo, Gotoh, Kazuma, Ishida, Hiroyuki   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

4-(4-Pyridyl)pyridinium 3-amino-5-carboxy-2,4,6-triiodobenzoate–5-amino-2,4,6-triiodoisophthalic acid (1/1)

Acta Crystallographica Section E, 2010
In the title ammonium carboxylate–carboxylic acid co-cystal, C10H9N2+·C8H3I3NO4−.C8H4I3NO4, the carboxylate anion and carboxylic acid molecule are linked by O—H...O and N—H...O hydrogen bonds to form a ...
Kou-Lin Zhang, Seik Weng Ng, Guo-Wang Diao   +2 more
doaj   +1 more source

3-[(2-Hydroxybenzyl)azaniumyl]propanoate monohydrate [PDF]

, 2016
The title compound, C10H13NO3·H2O, is a zwitterion hydrate with the zwitterion comprising a central ammonium group and a carboxyl­ate residue. In the zwitterion, the hy­droxy­benzene and carboxyl­ate groups are directed to the same side of the mol­ecule ...
Basu Baul, Tushar S., Chaurasiya, Anurag, Tiekink, Edward R. T. *   +2 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

N-Cyclo­hexyl-3,4,5-trimethoxy­benzamide [PDF]

, 2009
The 3,5-meth­oxy groups in the title compound, C16H23NO4, are almost coplanar with the aromatic ring, whereas the 4-meth­oxy group is bent out of this plane. The three CH3—O—C—C torsion angles are -1.51 (18), 0.73 (19) and 75.33 (15)°.
Saeed, Aamer, Arshad, Muhammad, Khera, Rasheed Ahmad, Bolte, Michael   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

2-Amino-5-chloropyridinium hydrogen succinate

Acta Crystallographica Section E, 2010
In the title salt, C5H6ClN2+·C4H5O4−, the pyridine N atom is protonated. The pyridinium and amino groups associate via a pair of N—H...O hydrogen bonds to the carboxylate O atoms of the singly deprotonated succinate anion ...
Madhukar Hemamalini, Hoong-Kun Fun
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source