Results 81 to 90 of about 269,935 (266)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Estudo teórico sobre o efeito de substituintes na estrutura eletrônica de supermoléculas com múltiplas ligações de hidrogênio intermoleculares [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013Sistemas que se conectam através de múltiplas ligações de hidrogênio são a pedra angular ...
Lopez, Alfredo Henrique Duarte
core  

Hydrogen in Nominally Anhydrous Crustal Minerals [PDF]

, 2003
Systematic infrared and nuclear magnetic resonance investigations of common crustal minerals were undertaken to better understand the geologic significance of minor components of structural hydrous species within these nominally anhydrous minerals ...
Johnson, Elizabeth Ann
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Crystal structures of the three closely related compounds: bis[(1H-tetrazol-5-yl)methyl]nitramide, triaminoguanidinium 5-({[(1H-tetrazol-5-yl)methyl](nitro)amino}methyl)tetrazol-1-ide, and diammonium bis[(tetrazol-1-id-5-yl)methyl]nitramide monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the molecule of neutral bis[(1H-tetrazol-5-yl)methyl]nitramide, (I), C4H6N10O2, there are two intramolecular N—H...O hydrogen bonds. In the crystal, N—H...N hydrogen bonds link molecules, forming a two-dimensional network parallel to (-201) and weak C—
Lauren A. Mitchell, Gregory H. Imler, Damon A. Parrish, Jeffrey R. Deschamps, Philip W. Leonard, David E. Chavez   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

2-Amino-5-chloropyridinium hydrogen succinate

Acta Crystallographica Section E, 2010
In the title salt, C5H6ClN2+·C4H5O4−, the pyridine N atom is protonated. The pyridinium and amino groups associate via a pair of N—H...O hydrogen bonds to the carboxylate O atoms of the singly deprotonated succinate anion ...
Madhukar Hemamalini, Hoong-Kun Fun
doaj   +1 more source

Unexpectedly Lengthened N−H···Co Hydrogen Bonds? [PDF]

, 2016
Low-temperature crystal structures of QuinH+Co(CO)4-, 1 (QuinH+ = quinuclidinium), (DABCO)H+Co(CO)3P(p-tolyl)3-, 2, and (DABCO)H+Co(CO)3PPh2(p-tolyl)-, 3 (DABCO = 1,4-diazabicyclooctane), 2 and 3 as their acetonitrile solvates, demonstrate that these ...
Lee Brammer (1306188), Juan C. Mareque Rivas (2977167), Dong Zhao (217545)   +2 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Ferrocenecarboxylic acid-1,4-diazabicyclo[2.2.2]octane (2/1): sheets built from O-H ... N and C-H ... O hydrogen bonds [PDF]

, 2001
In the title compound, 2[Fe(C5H5)(C6H5O2)].C6H12N2, the molecular components are linked into finite three-component aggregates by strong O-H . . . N hydrogen bonds [O . . . N 2.578 (4) and 2.604 (5) Angstrom; O-H . . .
Ferguson, G, Glidewell, C, Lough, A J, Zakaria, C M   +3 more
core   +2 more sources