N-Acetylaspartate Drives Oligodendroglial Differentiation via Histone Deacetylase Activation [PDF]
Cells, 2023 An unmet clinical goal in demyelinating pathologies is to restore the myelin sheath prior to neural degeneration. N-acetylaspartate (NAA) is an acetylated derivative form of aspartate, abundant in the healthy brain but severely reduced during traumatic ...
Alessandra Dominicis +6 more
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Electroconvulsive therapy triggers a reversible decrease in brain N-acetylaspartate [PDF]
Frontiers in Psychiatry, 2023 IntroductionBased on previous research on electroconvulsive therapy (ECT) we have proposed a model where disruption, potentiation, and rewiring of brain networks occur in sequence and serve as the underlying therapeutic mechanism of ECT.
Vera J. Erchinger +18 more
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Association between brain N-acetylaspartate levels and sensory and motor dysfunction in patients who have spinal cord injury with spasticity: an observational case-control study [PDF]
Neural Regeneration Research, 2023 Spinal cord injury is a severe and devastating disease, and spasticity is a common and severe complication that is notoriously refractory to treatment.
Jia-Yi Liu +6 more
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The cAMP Inducers Modify N-Acetylaspartate Metabolism in Wistar Rat Brain [PDF]
Antioxidants, 2021 Neuronal N-acetylaspartate production appears in the presence of aspartate N-acetyltransferase (NAT8L) and binds acetyl groups from acetyl-CoA with aspartic acid.
Robert Kowalski +5 more
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N-Acetylaspartate Is an Important Brain Osmolyte [PDF]
Biomolecules, 2020 Most of the human diseases related to various proteopathies are confined to the brain, which leads to the development of various forms of neurological disorders.
Marina Warepam +5 more
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Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease [PDF]
Brain Sciences, 2022 Alzheimer’s disease (AD) was recently defined as a biological construct to reflect neuropathologic status, and both abnormal amyloid and tau are required for a diagnosis of AD.
Qianyun Chen +12 more
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Brain Metabolite, N-Acetylaspartate Is a Potent Protein Aggregation Inhibitor [PDF]
Frontiers in Cellular Neuroscience, 2021 Deposition of toxic protein inclusions is a common hallmark of many neurodegenerative disorders including Alzheimer's disease, Parkinson disease etc.
Marina Warepam +7 more
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The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons [PDF]
Antioxidants, 2020 N-acetylaspartate is produced by neuronal aspartate N-acetyltransferase (NAT8L) from acetyl-CoA and aspartate. In cholinergic neurons, acetyl-CoA is also utilized in the mitochondrial tricarboxylic acid cycle and in acetylcholine production pathways ...
Marlena Zyśk +5 more
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Extracellular N-Acetylaspartate in Human Traumatic Brain Injury. [PDF]
J Neurotrauma, 2016 N-acetylaspartate (NAA) is an amino acid derivative primarily located in the neurons of the adult brain. The function of NAA is incompletely understood.
Shannon RJ +6 more
europepmc +9 more sources
Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases [PDF]
MedicinaBackground and Objectives: Differentiating between a high-grade glioma (HGG) and solitary cerebral metastasis presents a challenge when using standard magnetic resonance imaging (MRI) alone.
Jelena Ostojic +6 more
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