Proton magnetic resonance spectroscopy (1H-MRS) allows measuring specific brain metabolic alterations in Huntington's disease (HD), and these metabolite profiles may serve as non-invasive biomarkers associated with disease progression.
Yinghua Jing +3 more
doaj +1 more source
Ömer Başay,1 Burge Kabukcu Basay,1 Huseyin Alacam,2 Onder Ozturk,1 Ahmet Buber,1 Senay Gorucu Yilmaz,3 Yılmaz Kıroğlu,4 Mehmet Emin Erdal,5 Hasan Herken2 1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University,
Başay +8 more
doaj
NMR metabolomics reveals metabolic alterations in a novel mouse model of neurodegeneration
IntroductionThe relationship between brain metabolism and neurodegenerative diseases is poorly understood. To investigate the pathophysiology of neurodegeneration, we used decrepit (dcr) mice, a mouse model with a mutation in a mitochondrial associated ...
Grace V. Mercer +8 more
doaj +1 more source
Renewal of oligodendrocyte lineage reverses dysmyelination and CNS neurodegeneration through corrected N-acetylaspartate metabolism. [PDF]
Lotun A +13 more
europepmc +1 more source
Rett syndrome is a thief! It robs little girls of their projected life. It lulls their families into a false sense of security while their little girls develop normally for 6 to 18 months.
Cox, Deborah Ann
core
Associations between N-Acetylaspartate and white matter integrity in individuals with schizophrenia and unaffected relatives. [PDF]
Roberts D +3 more
europepmc +1 more source
N-Acetylaspartate and Choline Metabolites in Cortical and Subcortical Regions in Clinical High Risk Relative to Healthy Control Subjects: An Exploratory 7T MRSI Study. [PDF]
Mayeli A +8 more
europepmc +1 more source
Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status. [PDF]
Yang YS, Smucny J, Zhang H, Maddock RJ.
europepmc +1 more source
N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages. [PDF]
Menga A +15 more
europepmc +1 more source

