Results 171 to 180 of about 14,619 (195)

Immunohistochemical localization of N-acetylaspartate in rat brain

NeuroReport, 1991
N-acetylaspartate (NAA) is one of the most prevalent compounds in the mammalian nervous system. As such, NAA largely contributes to the major peak on water-suppressed proton magnetic resonance spectra. Highly specific antibodies to NAA demonstrate that this compound is discretely localized in a substantial number of neurons throughout the extent of the
J R, Moffett, M A, Namboodiri, C B, Cangro, J H, Neale   +3 more
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An enzymatic fluorimetric assay for determination of N-acetylaspartate

Analytical Biochemistry, 2023
N-acetylaspartate (NAA) is an abundant metabolite in the mammalian brain and a precursor of the neuropeptide N-acetylaspartylglutamate (NAAG). The physiological role of NAA is not fully understood and requires further studies. We here describe the development of a coupled enzymatic fluorimetric assay for the determination of NAA in biological samples ...
Ivonne Becker, Matthias Eckhardt
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Decreased N-Acetylaspartate in children with familial bipolar disorder

Biological Psychiatry, 2003
Relatively low levels of brain N-acetylaspartate, as measured by magnetic resonance spectroscopy, may indicate decreased neuronal density or viability. Dorsolateral prefrontal levels of N-acetylaspartate have been reported to be decreased in adults with bipolar disorder.
Chang, Kiki, Adleman, Nancy, Dienes, Kimberly, Barnea-Goraly, Naama, Reiss, Allan, Ketter, Terence   +5 more
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Reduced hippocampal N-acetylaspartate without volume loss in schizophrenia

Schizophrenia Research, 1999
Quantitative magnetic resonance imaging (MRI) can measure total gray matter volume but cannot discriminate between neurons and glia. Proton magnetic resonance spectroscopic imaging (1H MRSI) measures N-acetylaspartate (NAA) which is a selective marker of neuronal loss or neuronal dysfunction.
R F, Deicken, M, Pegues, D, Amend
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Reduced prefrontal N-acetylaspartate in stroke patients with apathy

Journal of the Neurological Sciences, 2005
Although substantial numbers of stroke patients suffer from apathy, its causes are still poorly understood. Previous studies suggest that dysfunction of the frontal lobes is implicated in the pathophysiology of motivation. Our aim was to investigate the association between proton magnetic resonance spectroscopy (H1-MRS) measurements in unaffected ...
Lidia, Glodzik-Sobanska, Agnieszka, Slowik, Agnieszka, Kieltyka, Justyna, Kozub, Barbara, Sobiecka, Andrzej, Urbanik, Andrzej, Szczudlik   +6 more
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Reduced N-acetylaspartate Levels and Cognitive Decline

Archives of Neurology, 2004
T he report by Enzinger et al 1 confirms the earlier study by Chapman et al regarding the predictive value of the apolipoprotein E 4 allele (APOE 4) for severity in multiple sclerosis. Reduced Nacetylaspartate levels have been shown to be valuable markers for cognitive decline in several diseases, including Alzheimer disease and multiple sclerosis (C ...
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N-acetylaspartate: Serum marker of reperfusion in ischemic stroke

Journal of Stroke and Cerebrovascular Diseases, 2004
Conventional ways of monitoring reperfusion in acute ischemic stroke have several limitations. In searching for an alternative, we evaluated biochemical serum markers of stroke change in relation to reperfusion. N-acetylaspartate (NAA) is a small amino acid synthesized by neuronal mitochondria, which can be released in the extracellular space after ...
Elting, J.w., Sulter, G., Langedijk, M., Luijckx, G.j., Teelken, A.w., De Keyser, Jacques   +5 more
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N-acetylaspartate synthesis in the brain: Mitochondria vs. microsomes

Brain Research, 2008
Several reports during the last three decades have indicated that biosynthesis of N-acetylaspartate (NAA) occurs primarily in the mitochondria. But a recent report by Lu et al. in this journal [2004; 122: 71-78] and subsequent two reports that cited those data suggested a predominant microsomal localization of the NAA biosynthetic enzyme, which is ...
Prasanth S, Ariyannur, Chikkathur N, Madhavarao, Aryan M A, Namboodiri   +2 more
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N-Acetylaspartate in the Vertebrate Brain: Metabolism and Function

Neurochemical Research, 2003
N-Acetyl-L-aspartate (NAA) is an amino acid that is present in the vertebrate brain. Its concentration is one of the highest of all free amino acids and, although NAA is synthesized and stored primarily in neurons, it cannot be hydrolyzed in these cells.
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Aspartoacylase Deficiency (Canavan Disease, N-Acetylaspartic Aciduria)

2019
CD is a rare, autosomal recessive neurometabolic disorder with often devastating clinical consequences. It typically presents in early infancy. Clinical symptoms and MRI-based findings are chronic neurological deterioration with irritability and severe global developmental delay, loss of early milestones, macrocephaly, and seizures together with white ...
Jörn Oliver Sass, Ina Knerr
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