Results 11 to 20 of about 14,619 (195)

Decreased N-acetylaspartate plus N-acetyl-aspartyl-glutamate levels in the caudate of schizophrenia patients with tardive dyskinesia [PDF]

Scientific Reports
Tardive dyskinesia (TD) may reflect an intrinsic neurobiological vulnerability associated with schizophrenia, yet metabolic alterations in the caudate nucleu, a key brain region regulating involuntary movements-remain poorly characterized by proton ...
Ting Yu, Yanli Li, Na Li, Mengzhuang Gou, Wenjin Chen, Zhiren Wang, Shuping Tan, Fude Yang, Baopeng Tian, Xingguang Luo, Yunlong Tan   +10 more
doaj   +2 more sources

Serine, N-acetylaspartate differentiate adolescents with juvenile idiopathic arthritis compared with healthy controls: a metabolomics cross-sectional study [PDF]

Pediatric Rheumatology Online Journal, 2022
Background In comparison with the general population, adolescents with juvenile idiopathic arthritis (JIA) are at higher risk for morbidity and mortality.
Kimberly A. Lewis, Nico Osier, Ruy Carrasco, Jennifer Chiou, Patricia Carter, Alexandra Garcia, Elena Flowers, Efstathios D. Gennatas, Christina Nguyen, Ambreen Rana, Sharon A. Brown, Stefano Tiziani   +11 more
doaj   +2 more sources

N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase [PDF]

Neurobiology of Disease, 2016
Breakdown of neuro-glial N-acetyl-aspartate (NAA) metabolism results in the failure of developmental myelination, manifest in the congenital pediatric leukodystrophy Canavan disease caused by mutations to the sole NAA catabolizing enzyme aspartoacylase ...
Jeremy S. Francis, PhD, Ireneusz Wojtas, PhD, Vladimir Markov, MD, Steven J. Gray, PhD, Thomas J. McCown, PhD, R. Jude Samulski, PhD, Larissa T. Bilaniuk, MD, Dah-Jyuu Wang, PhD, Darryl C. De Vivo, MD, Christopher G. Janson, MD, Paola Leone, PhD   +10 more
doaj   +2 more sources

N-acetylaspartate mitigates pro-inflammatory responses in microglial cells by intersecting lipid metabolism and acetylation processes [PDF]

Cell Communication and Signaling
Background Microglia play a crucial role in brain development and repair by facilitating processes such as synaptic pruning and debris clearance.
Federica Felice, Pamela De Falco, Martina Milani, Serena Castelli, Antonella Ragnini-Wilson, Giacomo Lazzarino, Nadia D’Ambrosi, Fabio Ciccarone, Maria Rosa Ciriolo   +8 more
doaj   +2 more sources

Newfound effect of N-acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro [PDF]

Neurobiology of Disease, 2018
Although N-acetylaspartate (NAA) has long been recognized as the most abundant amino acid in neurons by far, its primary role has remained a mystery.
Jean-Pierre Dollé, Jeffrey M. Rodgers, Kevin D. Browne, Thomas Troxler, Feng Gai, Douglas H. Smith   +5 more
doaj   +2 more sources

N-acetylaspartate concentration in psychotic disorders: T2-relaxation effects. [PDF]

Schizophr Res, 2021
We used proton magnetic resonance spectroscopy (1H MRS) to quantify N-acetylaspartate (NAA) concentrations and apparent spin-spin (T2) relaxation times, which also include diffusion attenuations, in first episode and chronic psychosis patients compared to matched healthy controls.
Kuan E, Chen X, Du F, Ongur D.
europepmc   +3 more sources

Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder

Frontiers in Psychiatry, 2020
Bipolar disorder (BD) is a severe psychiatric illness characterized by abnormalities in the immune/inflammatory function and in brain metabolism. Evidences suggest that inflammation may affect the levels of brain metabolites as measured by single-proton ...
Sara Poletti, Sara Poletti, Mario Gennaro Mazza, Mario Gennaro Mazza, Benedetta Vai, Benedetta Vai, Cristina Lorenzi, Cristina Colombo, Cristina Colombo, Francesco Benedetti, Francesco Benedetti   +10 more
doaj   +1 more source

Clinical Relevance of Single-Voxel 1 H Mrs Metabolites in Discriminating Suprasellar Tumors [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Spatially resolved metabolic data obtained from Proton Magnetic Resonance Spectroscopy (1 H MRS) provides information which increases the diagnostic accuracy of imaging sequences in predicting the histology of suprasellar tumors.
A EINSTIEN, RAHUL A VIRANI
doaj   +1 more source

N-acetylaspartate from fat cells regulates postprandial body temperature. [PDF]

Nat Metab
Abstract N-acetylaspartate (NAA), the brain's second most abundant metabolite, provides essential substrates for myelination through its hydrolysis. However, activities and physiological roles of NAA in other tissues remain unknown. Here, we show aspartoacylase (ASPA) expression in white adipose tissue (WAT) governs systemic NAA levels for ...
Felix JB, Saha PK, de Groot EL, Tan L, Sharp R, Anaya ES, Li Y, Quang H, Saidi N, Abushamat L, Ballantyne CM, Amos CI, Lorenzi PL, Klein S, Gao X, Hartig SM.   +15 more
europepmc   +4 more sources

Neurometabolite alterations in traumatic brain injury and associations with chronic pain

Frontiers in Neuroscience, 2023
Traumatic brain injury (TBI) can lead to a variety of comorbidities, including chronic pain. Although brain tissue metabolite alterations have been extensively examined in several chronic pain populations, it has received less attention in people with ...
Linda E. Robayo, Linda E. Robayo, Varan Govind, Teddy Salan, Nicholas P. Cherup, Sulaiman Sheriff, Andrew A. Maudsley, Eva Widerström-Noga, Eva Widerström-Noga, Eva Widerström-Noga   +9 more
doaj   +1 more source